2024
Pig-to-human kidney xenotransplants using genetically modified minipigs
Wang Y, Chen G, Pan D, Guo H, Jiang H, Wang J, Feng H, He S, Du J, Zhang M, Li T, Wang Y, Yu H, Gan H, Wen Q, Song Z, Li D, Yu Y, Wang H, Li B, You Y, Zhou S, Wang M, Liu L, Xu L, Yang M, Pei H, Zhang K, Chen Z. Pig-to-human kidney xenotransplants using genetically modified minipigs. Cell Reports Medicine 2024, 5: 101744. PMID: 39317190, PMCID: PMC11513830, DOI: 10.1016/j.xcrm.2024.101744.Peer-Reviewed Original ResearchConceptsAntibody-mediated rejectionNatural killer (NK) cellsT cell-mediated rejectionCell-mediated rejectionHuman gene transferKidney function recoveryXenogeneic immune responsesTriple-gene knockoutPig-to-humanAcute rejectionCD40-CD154Pathway blockadeXenograft successMacrophage infiltrationXenograft functionImmunopathological changesKidney xenotransplantationBrain-dead patientsImmune responseDonor pigsFunctional recoveryClinical observationsImmunosuppressionGene transferKidney
2022
Immunopathological changes, complications, sequelae and immunological memory in COVID-19 patients
Yao L, Lu L, Ma W. Immunopathological changes, complications, sequelae and immunological memory in COVID-19 patients. Heliyon 2022, 8: e09302. PMID: 35497026, PMCID: PMC9040416, DOI: 10.1016/j.heliyon.2022.e09302.Peer-Reviewed Original ResearchCOVID-19 patientsSARS-CoV-2Immunological memoryMultiple organsHealth problemsSARS-CoV-2 infectionACE2 protein levelsMultidisciplinary care teamCOVID-19 survivorsLong-term health problemsSARS-CoV-2 virusImmunopathological changesImmunological changesSevere complicationsOrgan failureModerate symptomsSevere illnessCare teamFurther managementLung tissueComplicationsPatientsDisease casesMajor organsReceptors results
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply