2025
Acquired angio-oedema as a mimicker of drug allergy
Liao J, Mathew M, Elmansy L, Hsu F, Belmont A. Acquired angio-oedema as a mimicker of drug allergy. BMJ Case Reports 2025, 18: e265525. PMID: 40389294, DOI: 10.1136/bcr-2025-265525.Peer-Reviewed Original ResearchConceptsAcquired angio-oedemaAngio-oedemaSplenic marginal zone lymphomaBradykinin-mediated diseaseSevere angio-oedemaMarginal zone lymphomaLocal anaesthetic allergyDrug allergy testingDental proceduresAcute therapyCase reportClinical historyDrug allergyAllergy centresAllergy testingClinical pearlsClinical diagnosisEmergency departmentMultiple physiciansDiagnosisAllergyLymphomaTherapyPatientsAetiology
2023
Acute Adverse Events After Iodinated Contrast Agent Administration of 359,977 Injections: A Single-Center Retrospective Study
McDonald J, Larson N, Schmitz J, Kolbe A, Hunt C, Hartman R, Hagan J, Kallmes D, McDonald R. Acute Adverse Events After Iodinated Contrast Agent Administration of 359,977 Injections: A Single-Center Retrospective Study. Mayo Clinic Proceedings 2023, 98: 1820-1830. PMID: 38043998, DOI: 10.1016/j.mayocp.2023.02.032.Peer-Reviewed Original ResearchMeSH KeywordsContrast MediaDrug HypersensitivityFemaleHumansIohexolRetrospective StudiesRisk FactorsConceptsNon-white patientsWhite patientsExamination variablesSingle-center retrospective studyHigh rateAcute adverse eventsEffect of patientAllergic-like reactionsPhysiologic reactionsComputed tomography examinationCT locationLogistic regression modelsContrast agent administrationICM allergyYounger patientsAdverse eventsPatient ageMultivariable analysisRetrospective studyUnique patientsAcute reactionsFemale sexPatient variablesTomography examinationCT examinationsEvaluating the PEN-FAST Clinical Decision-making Tool to Enhance Penicillin Allergy Delabeling
Su C, Belmont A, Liao J, Kuster J, Trubiano J, Kwah J. Evaluating the PEN-FAST Clinical Decision-making Tool to Enhance Penicillin Allergy Delabeling. JAMA Internal Medicine 2023, 183: 883-885. PMID: 37338869, PMCID: PMC10282954, DOI: 10.1001/jamainternmed.2023.1572.Peer-Reviewed Original ResearchA safe, effective, and single-day protocol for rapid drug desensitization to intravenous iron dextran
Belmont A, Liao J, Hsu F, Kwah J. A safe, effective, and single-day protocol for rapid drug desensitization to intravenous iron dextran. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 3242-3244.e1. PMID: 37329952, DOI: 10.1016/j.jaip.2023.06.018.Peer-Reviewed Original ResearchAntibiotic choice for Group B Streptococcus prophylaxis in mothers with reported penicillin allergy and associated newborn outcomes
Snider J, Mithal L, Kwah J, Rhodes N, Son M. Antibiotic choice for Group B Streptococcus prophylaxis in mothers with reported penicillin allergy and associated newborn outcomes. BMC Pregnancy And Childbirth 2023, 23: 400. PMID: 37254067, PMCID: PMC10228028, DOI: 10.1186/s12884-023-05697-0.Peer-Reviewed Original ResearchConceptsGroup B streptococcus prophylaxisReported penicillin allergyPenicillin allergyGBS prophylaxisLab drawsNeonatal outcomesNewborn outcomesAntibiotic administrationMedical recordsPregnant individualsIntrapartum group B streptococcus prophylaxisNeonatal intensive care unit admissionDesignThis retrospective cohort studyIntensive care unit admissionSelf-reported penicillin allergyNeonates of mothersCare unit admissionIntrapartum antibiotic prophylaxisRetrospective cohort studyWeeks of gestationMother-infant pairsMother-infant dyadsBeta-lactam antibioticsAntibiotic prophylaxisUnit admissionPerioperative Anaphylaxis: Comment
Valach M, Patel C, Hyman J, Sweitzer B. Perioperative Anaphylaxis: Comment. Anesthesiology 2023, 139: 359-360. PMID: 37247349, DOI: 10.1097/aln.0000000000004596.Commentaries, Editorials and LettersCephalosporins can be safely administered to patients with verified penicillin allergy
Belmont A, Su C, Kwah J. Cephalosporins can be safely administered to patients with verified penicillin allergy. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 2933-2935.e2. PMID: 37245737, DOI: 10.1016/j.jaip.2023.05.027.Peer-Reviewed Original Research
2022
Survey of Obstetric Providers to Assess the Knowledge and Management of a Reported Penicillin Allergy in Pregnant Women
Cate JJM, Burn M, Kwah J, Liao J, Illuzzi J, Reddy U, Son M. Survey of Obstetric Providers to Assess the Knowledge and Management of a Reported Penicillin Allergy in Pregnant Women. American Journal Of Perinatology 2022, 40: 001-008. PMID: 35709740, DOI: 10.1055/a-1877-9970.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsDrug HypersensitivityFemaleHumansHypersensitivityParturitionPenicillinsPregnancyPregnant PeopleSurveys and QuestionnairesConceptsPenicillin skin testingReported penicillin allergyPenicillin allergyObstetric providersPractice patternsEducational sessionsAllergy knowledgeProvider knowledgeEducational interventionSingle academic medical centerPenicillin allergy delabelingPenicillin allergy evaluationPenicillin allergy testingPercentage of patientsIdentification of patientsClinical practice patternsSmall group educational sessionsAcademic medical centerChi-square testAllergy evaluationPenicillin allergicPerinatal outcomesPregnant patientsDrug allergyAllergy testingOutpatient penicillin allergy evaluation during pregnancy and associated clinical outcomes
Kwah JH, Burn MS, Liao J, Cate J, Son M. Outpatient penicillin allergy evaluation during pregnancy and associated clinical outcomes. American Journal Of Obstetrics & Gynecology MFM 2022, 4: 100674. PMID: 35691578, DOI: 10.1016/j.ajogmf.2022.100674.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsDrug HypersensitivityFemaleHumansInfant, NewbornOutpatientsPenicillinsPregnancyRetrospective StudiesConceptsPenicillin allergy evaluationPenicillin allergyPregnant womenAllergy evaluationHospital stayNeonatal outcomesClinical benefitIntensive care unit admissionBirth hospitalization lengthUnverified penicillin allergyCare unit admissionNeonatal adverse outcomesRetrospective cohort studyMedical record reviewPostpartum hospital stayAdditional clinical benefitLarge academic hospitalElectronic medical recordsBeta-lactam antibioticsPostpartum infectionReferred womenUnit admissionMaternal outcomesCohort studyTrue allergyCharacteristics and prevalence of antibiotic allergies in patients with sickle cell disease: A single‐center retrospective study
Wong KH, Soffer GK. Characteristics and prevalence of antibiotic allergies in patients with sickle cell disease: A single‐center retrospective study. American Journal Of Hematology 2022, 97: e247-e249. PMID: 35358357, DOI: 10.1002/ajh.26555.Peer-Reviewed Original Research
2020
HIPEC with cisplatin in a patient with a prior hypersensitivity reaction to systemic oxaliplatin
Morgan R, Parsad S, Turaga K, Eng O. HIPEC with cisplatin in a patient with a prior hypersensitivity reaction to systemic oxaliplatin. Basic & Clinical Pharmacology & Toxicology 2020, 127: 551-553. PMID: 32623784, DOI: 10.1111/bcpt.13464.Peer-Reviewed Original ResearchConceptsHyperthermic intraperitoneal chemotherapyHypersensitivity reactionsSystemic oxaliplatinDiscontinued due to toxicityPlatinum-based chemotherapeutic agentsAlternative routes of administrationPlatinum-based agentsRoute of administrationIntraperitoneal chemotherapySystemic therapyDesensitization protocolCross-reactivityCase reportChemotherapeutic agentsSkin testPatientsCisplatinTherapyOxaliplatinAdverse effectsSafety parametersHypersensitivityPlatinum saltsDesensitizationAgents
2019
Etoposide phosphate for pediatric orthopedic malignancies after intravenous etoposide hypersensitivity
Brooks JP, Azmy V, Thompson A, Luon D, Prozora SD, Price C, Hsu FI. Etoposide phosphate for pediatric orthopedic malignancies after intravenous etoposide hypersensitivity. Journal Of Oncology Pharmacy Practice 2019, 26: 228-231. PMID: 30885040, DOI: 10.1177/1078155219836478.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBone NeoplasmsDrug HypersensitivityEtoposideHumansMaleOrganophosphorus CompoundsOsteosarcomaSarcoma, EwingConceptsOrthopedic malignanciesHypersensitivity reactionsEtoposide phosphatePediatric patientsEtoposide hypersensitivityLarge academic medical centerAcademic medical centerCase of etoposideContinued therapyChart reviewFurther therapyFirst dosesFull dosesEwing's sarcomaMedical CenterPatientsMalignancySafe alternativeEtoposideHypersensitivityTherapyDiphenhydramineDosesPremedicationSarcoma
2018
Impact of carboplatin hypersensitivity and desensitization on patients with recurrent ovarian cancer
Altwerger G, Florsheim EB, Menderes G, Black J, Schwab C, Gressel GM, Nelson WK, Carusillo N, Passante T, Huang G, Litkouhi B, Azodi M, Silasi DA, Santin A, Schwartz PE, Ratner ES. Impact of carboplatin hypersensitivity and desensitization on patients with recurrent ovarian cancer. Journal Of Cancer Research And Clinical Oncology 2018, 144: 2449-2456. PMID: 30255380, PMCID: PMC11813260, DOI: 10.1007/s00432-018-2753-y.Peer-Reviewed Original ResearchConceptsCarboplatin hypersensitivityCarboplatin desensitizationHypersensitive patientsOverall survivalRisk factorsOvarian cancerTwo-sided Fisher exactAdvanced stage ovarian cancerInfusion of carboplatinRecurrent ovarian cancerIndependent risk factorLonger overall survivalStage ovarian cancerOvarian cancer patientsLong-term treatmentNew risk factorsHigher likelihoodTwo-sided p valueT-testStudent's t-testDesignRetrospective studyGermline BRCA1/2Improved OSLonger OSDesensitization protocol
2017
Current insight in the localized insulin-derived amyloidosis (LIDA): clinico-pathological characteristics and differential diagnosis
Ansari AM, Osmani L, Matsangos AE, Li QK. Current insight in the localized insulin-derived amyloidosis (LIDA): clinico-pathological characteristics and differential diagnosis. Pathology - Research And Practice 2017, 213: 1237-1241. PMID: 28935176, DOI: 10.1016/j.prp.2017.08.013.Peer-Reviewed Original ResearchConceptsInsulin-derived amyloidosisSystemic amyloidosisDiabetic patientsGlycemic controlDifferential diagnosisAccurate diagnosisAggressive systemic therapyBlood glycemic controlCommon side effectsCase series studyClinico-pathological characteristicsNon-surgical approachSubcutaneous insulin injectionsPrimary cutaneous amyloidosisAnti-insulin antibodiesAutonomic neuropathyInsulin requirementsClinical suspicionKey diagnostic featuresRare complicationSystemic therapySurgical excisionSurgical interventionCase reportInsulin injectionsShared peptide binding of HLA Class I and II alleles associate with cutaneous nevirapine hypersensitivity and identify novel risk alleles
Pavlos R, McKinnon EJ, Ostrov DA, Peters B, Buus S, Koelle D, Chopra A, Schutte R, Rive C, Redwood A, Restrepo S, Bracey A, Kaever T, Myers P, Speers E, Malaker SA, Shabanowitz J, Jing Y, Gaudieri S, Hunt DF, Carrington M, Haas DW, Mallal S, Phillips EJ. Shared peptide binding of HLA Class I and II alleles associate with cutaneous nevirapine hypersensitivity and identify novel risk alleles. Scientific Reports 2017, 7: 8653. PMID: 28819312, PMCID: PMC5561238, DOI: 10.1038/s41598-017-08876-0.Peer-Reviewed Original ResearchConceptsHypersensitivity reactionsHLA moleculesTreatment-limiting hypersensitivity reactionClass IDrug hypersensitivity syndromeHuman leukocyte antigen (HLA) systemHLA class IHLA-C allelesClass II allelesLeukocyte antigen systemHLA-B allelesNevirapine hypersensitivityHypersensitivity syndromeHLA associationsIndependent associationHLA-DRB1T cellsImmune responseNovel risk allelesPathogenic mechanismsDrug specific interactionsMultiple class IAntigen systemPrimary predispositionRisk allelesJOURNAL CLUB: Benefit of Epinephrine Autoinjector for Treatment of Contrast Reactions: Comparison of Errors, Administration Times, and Provider Preferences.
Asch D, Pfeifer KE, Arango J, Staib L, Cavallo J, Kirsch JD, Arici M, Pahade J. JOURNAL CLUB: Benefit of Epinephrine Autoinjector for Treatment of Contrast Reactions: Comparison of Errors, Administration Times, and Provider Preferences. American Journal Of Roentgenology 2017, 209: w363-w369. PMID: 28570127, DOI: 10.2214/ajr.16.17111.Peer-Reviewed Original ResearchPharmacogenomics of off‐target adverse drug reactions
Garon SL, Pavlos RK, White KD, Brown NJ, Stone CA, Phillips EJ. Pharmacogenomics of off‐target adverse drug reactions. British Journal Of Clinical Pharmacology 2017, 83: 1896-1911. PMID: 28345177, PMCID: PMC5555876, DOI: 10.1111/bcp.13294.Peer-Reviewed Original ResearchConceptsAdverse drug reactionsSevere cutaneous adverse reactionsTarget adverse drug reactionsDrug reactionsImmunological memoryTherapeutic effectHuman leukocyte antigen (HLA) associationsCutaneous adverse reactionsStrong human leukocyte antigen (HLA) associationDrug therapeutic effectsIM-ADRsMaculopapular exanthemaClinical featuresOptimal therapySignificant morbidityAdverse reactionsAntigen associationsPharmacological actionsTherapeutic targetDisease pathophysiologyClinical phenotypePreclinical testingGreater riskDrug metabolismPatient safety
2016
Platinum desensitization in patients with carboplatin hypersensitivity: A single-institution retrospective study
Altwerger G, Gressel GM, English DP, Nelson WK, Carusillo N, Silasi DA, Azodi M, Santin A, Schwartz PE, Ratner ES. Platinum desensitization in patients with carboplatin hypersensitivity: A single-institution retrospective study. Gynecologic Oncology 2016, 144: 77-82. PMID: 27789084, DOI: 10.1016/j.ygyno.2016.09.027.Peer-Reviewed Original ResearchConceptsPositive skin testsHypersensitivity reactionsDesensitization protocolSkin testCarboplatin infusionLife-threatening hypersensitivity reactionSingle-institution retrospective studyCarboplatin desensitization protocolPrior hypersensitivity reactionMajority of patientsCarboplatin hypersensitivity reactionsCarboplatin hypersensitivityPulmonary hypertensionAdverse eventsRetrospective reviewRetrospective studyGynecologic cancerGrade 0Patient deathRisk factorsCardiac conditionsPatientsLarger studyInfusionAgeSafety, Costs, and Efficacy of Rapid Drug Desensitizations to Chemotherapy and Monoclonal Antibodies
Sloane D, Govindarajulu U, Harrow-Mortelliti J, Barry W, Hsu FI, Hong D, Laidlaw T, Palis R, Legere H, Bunyavanich S, Breslow R, Wesemann D, Barrett N, Brennan P, Chong HJ, Liu A, Fernandez J, Fanning L, Kyin T, Cahill K, Bankova L, Lynch A, Berlin S, Campos S, Fuchs C, Mayer R, Matulonis U, Castells M. Safety, Costs, and Efficacy of Rapid Drug Desensitizations to Chemotherapy and Monoclonal Antibodies. The Journal Of Allergy And Clinical Immunology In Practice 2016, 4: 497-504. PMID: 26895621, DOI: 10.1016/j.jaip.2015.12.019.Peer-Reviewed Original ResearchConceptsRapid drug desensitizationDrug desensitizationAllergic patientsLife expectancyMonoclonal antibodiesNonallergic control groupOptimal pharmacological agentsOverall health costsFirst-line therapyAdministration of carboplatinConnective tissue diseaseStandard of careIndividual patient reactionsDesensitized patientsNonallergic groupAllergic groupLine therapyRisk stratificationTissue diseaseHypersensitivity reactionsChronic diseasesOvarian cancerSevere reactionsNonsignificant increasePharmacological agents
2015
Medication Initiation Burden Required to Comply With Heart Failure Guideline Recommendations and Hospital Quality Measures
Allen LA, Fonarow GC, Liang L, Schulte PJ, Masoudi FA, Rumsfeld JS, Ho PM, Eapen ZJ, Hernandez AF, Heidenreich PA, Bhatt DL, Peterson ED, Krumholz HM. Medication Initiation Burden Required to Comply With Heart Failure Guideline Recommendations and Hospital Quality Measures. Circulation 2015, 132: 1347-1353. PMID: 26316616, PMCID: PMC4941099, DOI: 10.1161/circulationaha.115.014281.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBody Mass IndexCardiovascular AgentsComorbidityContraindicationsCross-Sectional StudiesDrug HypersensitivityDrug PrescriptionsDrug SubstitutionDrug Therapy, CombinationDrug UtilizationEvidence-Based MedicineFemaleGuideline AdherenceHeart FailureHospitalsHumansMaleMedication AdherenceMiddle AgedPatient AdmissionPatient DischargePolypharmacyPractice Guidelines as TopicQuality Assurance, Health CareConceptsHF quality measuresHydralazine/isosorbide dinitrateAngiotensin receptor blockersMedication groupHeart failureAldosterone antagonistsReceptor blockersMedication regimenIsosorbide dinitrateNew medicationsΒ-blockersEnzyme inhibitorsGuideline-directed medical therapyInitiation of angiotensinPrimary discharge diagnosisQuarter of patientsPatient's medication regimenHospital quality measuresAdequate prescribingMedication initiationHospital dischargeHospital admissionMedical therapyGuideline recommendationsDischarge diagnosis
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