2025
Controversy in Hypertension: Pro-Side of the Argument Using Artificial Intelligence for Hypertension Diagnosis and Management
Armoundas A, Ahmad F, Attia Z, Doudesis D, Khera R, Kyriakoulis K, Stergiou G, Tang W. Controversy in Hypertension: Pro-Side of the Argument Using Artificial Intelligence for Hypertension Diagnosis and Management. Hypertension 2025, 82: 929-944. PMID: 40091745, PMCID: PMC12094096, DOI: 10.1161/hypertensionaha.124.22349.Peer-Reviewed Original ResearchConceptsArtificial intelligenceHypertension diagnosisBlood pressure elevationRelationship to cardiovascular diseaseManagement of hypertensionLong-term managementArtificial intelligence-based solutionsPressure elevationPublic health challengeHypertensionArtificial intelligence scienceComplex pathogenesisClinical implementationCardiovascular diseaseState-of-artDiagnosisData-driven approachHypertension managementIntelligence scienceClinical adoptionAn international perspective on the future of systemic sclerosis research
Abraham D, Black C, Denton C, Distler J, Domsic R, Feghali-Bostwick C, Gourh P, Hinchcliff M, Kolling F, Kuwana M, Lafyatis R, Landegren U, Mahoney J, Martin J, Matucci-Cerinic M, McMahan Z, Mora A, Mouthon L, Rabinovitch M, Rojas M, Rubin K, Trojanowska M, Varga J, Whitfield M, Gabrielli A, Krieg T. An international perspective on the future of systemic sclerosis research. Nature Reviews Rheumatology 2025, 21: 174-187. PMID: 39953141, DOI: 10.1038/s41584-024-01217-2.Peer-Reviewed Original ResearchConceptsSystemic sclerosisSystemic sclerosis researchHistory of systemic sclerosisInnovative clinical trial designsSystemic autoimmune diseaseEarly pathogenetic eventClinical trial designCollaborative global effortAutoimmune phenomenaImprove patient outcomesDisease activityMicrovascular dysfunctionClinical historyEmergency therapyAutoimmune diseasesDisease-modifying treatmentsTissue fibrosisSingle-cell RNA sequencingClinical heterogeneityEffective disease-modifying treatmentsPersonalized therapyAnimal modelsComplex pathogenesisEffective treatmentNext-generation sequencing
2022
Neutrophilic Dermatoses: a Clinical Update
Weiss EH, Ko CJ, Leung TH, Micheletti RG, Mostaghimi A, Ramachandran SM, Rosenbach M, Nelson CA. Neutrophilic Dermatoses: a Clinical Update. Current Dermatology Reports 2022, 11: 89-102. PMID: 35310367, PMCID: PMC8924564, DOI: 10.1007/s13671-022-00355-8.Peer-Reviewed Original ResearchNeutrophilic eccrine hidradenitisSterile neutrophilic infiltratesAnti-inflammatory therapyAbnormal neutrophil functionRecent FindingsRecent studiesNeutrophilic dermatosisSweet's syndromeBehçet's syndromeClinicopathological featuresNeutrophilic infiltrateSignificant morbidityClinical updateNeutrophil functionComplex pathogenesisDrug reactionsExtracutaneous manifestationsInflammasome activationNeoplastic disordersGenetic predispositionMalignant transformationDermatosesSyndromePathogenesisTherapeutic frameworkDisorders
2019
Vitamin E in Nonalcoholic Fatty Liver Disease
Banini B, Sanyal A. Vitamin E in Nonalcoholic Fatty Liver Disease. Nutrition And Health 2019, 311-323. DOI: 10.1007/978-3-030-05315-4_23.ChaptersNonalcoholic fatty liver diseaseVitamin E supplementationChronic liver diseaseFatty liver diseaseNonalcoholic steatohepatitisLiver diseaseE supplementationVitamin ESubtype of NAFLDAnnual direct medical costsChronic viral hepatitisAlcoholic liver diseaseClinical practice guidelinesDirect medical costsLong-term useNAFLD patientsLabel treatmentViral hepatitisPharmacological therapyComplex pathogenesisHistological featuresLiver fibrosisClinical trialsLeading causeClinical studiesImaging of Trigeminal Neuralgia
Pasquini L, Bozzao A. Imaging of Trigeminal Neuralgia. 2019, 83-118. DOI: 10.1007/978-3-319-99822-0_6.Peer-Reviewed Original ResearchTrigeminal neuralgiaTrigeminal nerveDiagnosis of trigeminal neuralgiaRecurrent episodes of painSymptoms of trigeminal neuralgiaCavernous sinus segmentEpisodes of painPathogenesis of painSecondary trigeminal neuralgiaSensory-motor nervesNeurovascular conflictCisternal segmentNeurovascular compressionRadiological investigationsFrequent neuropathyAutoimmune diseasesNeuralgiaSinus segmentCranial nervesInflammatory diseasesNerve fibersBrainstem segmentationComplex pathogenesisExtracranial segmentChronic insults
2006
An Inducible Mouse Model for PAX2-Dependent Glomerular Disease: Insights into a Complex Pathogenesis
Wagner KD, Wagner N, Guo JK, Elger M, Dallman MJ, Bugeon L, Schedl A. An Inducible Mouse Model for PAX2-Dependent Glomerular Disease: Insights into a Complex Pathogenesis. Current Biology 2006, 16: 793-800. PMID: 16631587, DOI: 10.1016/j.cub.2006.02.072.Peer-Reviewed Original ResearchConceptsInducible mouse modelGlomerular diseaseMouse modelAngiotensin-converting enzyme inhibitorEnd-stage renal failureTreatment of miceHealthy adult animalsRenal failureRenal functionRenal diseaseComplex pathogenesisNephrin expressionEnzyme inhibitorsDiseaseAdult animalsPodocytesDedifferentiated phenotypePersistent expressionMature podocytesPAX2MicePax genesFunctional relevanceTranscriptional repressorActivation
1975
Demonstration of Immune Complexes in Spontaneous and Histamine-Induced Lesions and in Normal Skin of Patients with Leukocytoclastic Angiitis
Braverman I, Yen A. Demonstration of Immune Complexes in Spontaneous and Histamine-Induced Lesions and in Normal Skin of Patients with Leukocytoclastic Angiitis. Journal Of Investigative Dermatology 1975, 64: 105-112. PMID: 123546, DOI: 10.1111/1523-1747.ep12510321.Peer-Reviewed Original ResearchConceptsHistamine-induced whealElectron-dense depositsImmune complexesUninvolved skinSpontaneous lesionsDirect immunofluorescenceImmune reactantsImmune complex pathogenesisImmune complex diseaseVessel wallLeukocytoclastic angiitisHistopathologic changesComplex pathogenesisLocal injectionNormal skinPostcapillary venulesLesionsPatientsWhealDamage ensuesImmunofluorescenceAngitisSkinNeutrophilsHistamine
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