2020
Mutations in KRT10 in epidermolytic acanthoma
Cheraghlou S, Atzmony L, Roy SF, McNiff JM, Choate KA. Mutations in KRT10 in epidermolytic acanthoma. Journal Of Cutaneous Pathology 2020, 47: 524-529. PMID: 32045015, PMCID: PMC7914398, DOI: 10.1111/cup.13664.Peer-Reviewed Original ResearchConceptsWhole-exome sequencingEpidermolytic acanthomaEpidermolytic hyperkeratosisHotspot mutationsCharacteristic histopathological patternEpidermolytic ichthyosisHistopathological patternsHistopathological analysisDiscovery cohortLesional tissueAdditional casesPolymerase chain reaction amplificationEpidermal degenerationChain reaction amplificationFragment length polymorphism analysisRestriction fragment length polymorphism analysisLength polymorphism analysisDermatosesIchthyosis bullosaAcanthomaKRT10Departmental archivesReaction amplificationIchthyosisPolymorphism analysis
2007
Monoclonal Antibodies Against LipL32, The Major Outer Membrane Protein of Pathogenic Leptospira Production, Characterization, and Testing in Diagnostic Applications
Fernandes C, Seixas FK, Coutinho ML, Vasconcellos F, Seyffert N, Croda J, McBride AJ, Ko AI, Dellagostin OA, Aleixo J. Monoclonal Antibodies Against LipL32, The Major Outer Membrane Protein of Pathogenic Leptospira Production, Characterization, and Testing in Diagnostic Applications. Monoclonal Antibodies In Immunodiagnosis And Immunotherapy 2007, 26: 35-41. PMID: 17316084, DOI: 10.1089/hyb.2006.033.Peer-Reviewed Original ResearchConceptsMembrane proteinsNative proteinMajor Outer Membrane ProteinOuter membrane lipoproteinOuter Membrane ProteinOuter membrane proteinsOuter membraneMembrane lipoproteinWide antigenic diversityBacterial cellsLeptospiral cellsIntact bacteriaProteinProtein enzyme-linked immunosorbent assayAntigenic diversityPolymerase chain reaction amplificationHeat-treated cellsMonoclonal antibodiesRecombinant formChain reaction amplificationEnzyme-linked immunosorbent assayFluorescein isothiocyanateCellsMurine monoclonal antibodiesPathogenic Leptospira
2002
Assessment of static isolator cages with automatic watering when used with conventional husbandry techniques as a factor in the transmission of mouse hepatitis virus.
Macy JD, Cameron GA, Ellis SL, Hill EA, Compton SR. Assessment of static isolator cages with automatic watering when used with conventional husbandry techniques as a factor in the transmission of mouse hepatitis virus. Journal Of The American Association For Laboratory Animal Science 2002, 41: 30-5. PMID: 12109894.Peer-Reviewed Original ResearchConceptsFilter-top cagesMouse hepatitis virusUninoculated miceHepatitis virusCages of miceTransmission of infectionExamination of fecesLong-term useImmunocompetent miceHigh virus concentrationsPolymerase chain reaction amplificationMiceChain reaction amplificationWeeksStandard cagesMHV-A59Fecal samplesRoutine husbandrySerologyTest cageVirusInfected cagesInfectionReaction amplificationRows of cages
2001
Persistent Productive Epstein-Barr Virus Replication in Normal Epithelial Cells In Vivo
Walling D, Flaitz C, Nichols C, Hudnall S, Adler-Storthz K. Persistent Productive Epstein-Barr Virus Replication in Normal Epithelial Cells In Vivo. The Journal Of Infectious Diseases 2001, 184: 1499-1507. PMID: 11740724, DOI: 10.1086/323992.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusEpstein-Barr virus replicationHairy leukoplakiaEBV replicationValacyclovir treatmentVirus replicationNormal tongue tissuesPersistent EBV infectionProductive EBV replicationReverse transcriptase-polymerase chain reaction amplificationOral hairy leukoplakiaEpithelial cellsOral epithelial lesionsTongue epithelial cellsEBV infectionNormal epithelial cellsEBV DNAImmunodeficiency virusBiopsy specimensEpithelial lesionsImmunohistochemical detectionLeukoplakiaPolymerase chain reaction amplificationTongue tissueChain reaction amplification
2000
Na+/H+ and Cl–/HCO3–-antiporters of bovine pigmented ciliary epithelial cells
Counillon L, Touret N, Bidet M, Peterson-Yantorno K, Coca-Prados M, Stuart-Tilley A, Wilhelm S, Alper S, Civan M. Na+/H+ and Cl–/HCO3–-antiporters of bovine pigmented ciliary epithelial cells. Pflügers Archiv - European Journal Of Physiology 2000, 440: 667-678. PMID: 11007305, DOI: 10.1007/s004240000302.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnion Transport ProteinsAntiportersCattleCell Line, TransformedChloride-Bicarbonate AntiportersCiliary BodyEpithelial CellsImmunohistochemistryMembrane ProteinsMicroscopy, FluorescenceMicroscopy, VideoModels, BiologicalPigmentationReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSLC4A ProteinsSodiumSodium-Hydrogen ExchangersConceptsAqueous humor formationCl-/HCO3Epithelial cell layerTranscriptase-polymerase chain reaction amplificationPE cellsCell layerHuman ciliary bodyAE2 Cl-/HCO3Medical therapyNHE-1 isoformCiliary epithelial cellsCiliary bodyAqueous humorCiliary epithelial bilayerPolymerase chain reaction amplificationChain reaction amplificationNHE-1Rabbit ciliary epitheliumCiliary epitheliumEpithelial cellsBovine pigmented ciliary epithelial cellsGap junctionsRegulatory volume increasePigmented ciliary epithelial cellsExternal Cl
1998
Granulocytic Ehrlichiosis in the Laboratory Mouse
Hodzic E, IJdo J, Feng S, Katavolos P, Sun W, Maretzki C, Fish D, Fikrig E, Telford S, Barthold S. Granulocytic Ehrlichiosis in the Laboratory Mouse. The Journal Of Infectious Diseases 1998, 177: 737-745. PMID: 9498456, DOI: 10.1086/514236.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisMouse passageGranulocytic ehrlichiosisHL-60 cell culturesPeripheral bloodC3H miceLate infectionEarly infectionCell culturesDay 17Day 5Blood smearsNormal valuesDay 24Polymerase chain reaction amplificationHGE agentChain reaction amplificationSpleen smearsMiceInfectionInfectivity assaysBloodLaboratory miceSmearsReaction amplificationMolecular cytogenetic analysis of patients with holoprosencephaly and structural rearrangements of 7q
Vance G, Nickerson C, Sarnat L, Zhang A, Henegariu O, Morichon‐Delvallez N, Butler M, Palmer C. Molecular cytogenetic analysis of patients with holoprosencephaly and structural rearrangements of 7q. American Journal Of Medical Genetics 1998, 76: 51-57. PMID: 9508065, PMCID: PMC6775641, DOI: 10.1002/(sici)1096-8628(19980226)76:1<51::aid-ajmg9>3.0.co;2-s.Peer-Reviewed Original ResearchMeSH KeywordsCell LineChromosome AberrationsChromosome DeletionChromosomes, Human, Pair 13Chromosomes, Human, Pair 22Chromosomes, Human, Pair 7CytogeneticsFemaleGenetic MarkersHedgehog ProteinsHoloprosencephalyHumansIn Situ Hybridization, FluorescenceInfantInfant, NewbornKaryotypingMaleMosaicismPolymerase Chain ReactionProteinsTrans-ActivatorsTranslocation, GeneticConceptsSonic hedgehog geneHedgehog geneCell linesDifferent chromosome regionsStructural rearrangementsHuman Sonic Hedgehog genePatient cell linesMolecular cytogenetic analysisChromosome regionsChromosome 7Embryonic forebrainLong armGenesSitu hybridizationPolymerase chain reaction amplificationHPE3Chain reaction amplificationCytogenetic analysisMidline cleavageReaction amplificationRearrangementPhenotypeCritical regionLinesHybridization
1997
Inhibition of efficient polymerase chain reaction amplification of Borrelia burgdorferi DNA in blood-fed ticks.
Schwartz I, Varde S, Nadelman R, Wormser G, Fish D. Inhibition of efficient polymerase chain reaction amplification of Borrelia burgdorferi DNA in blood-fed ticks. American Journal Of Tropical Medicine And Hygiene 1997, 56: 339-42. PMID: 9129540, DOI: 10.4269/ajtmh.1997.56.339.Peer-Reviewed Original ResearchConceptsB. burgdorferi DNABorrelia burgdorferi DNAB. burgdorferiInfection rateB. burgdorferi infectionPolymerase chain reaction analysisUtility of PCRInhibitory substancesBurgdorferi infectionChain reaction analysisPCR analysisPositive PCR signalUnfed ticksPolymerase chain reaction amplificationBlood-feeding ticksChain reaction amplificationTick lysatesEngorged ticksPCR amplificationBlood mealSuch inhibitionBurgdorferiEquivalent cohortsReaction amplificationInhibitors
1996
Prostate specific antigen in breast cancer, benign breast disease and normal breast tissue
Yu H, Diamandis E, Levesque M, Giai M, Roagna R, Ponzone R, Sismondi P, Monne M, Croce C. Prostate specific antigen in breast cancer, benign breast disease and normal breast tissue. Breast Cancer Research And Treatment 1996, 40: 171-178. PMID: 8879683, DOI: 10.1007/bf01806212.Peer-Reviewed Original ResearchConceptsBenign breast diseaseProstate-specific antigenNormal breast tissueBreast diseaseBreast tumorsBreast tissueBreast cancerSpecific antigenBreast cancer tissuesSteroid hormone actionPSA positivityPSA levelsDisease stageProstatic adenocarcinomaPSA productionTumor markersStage IBBD tissueCancer tissuesFemale breastSteroid hormonesLow expressionPolymerase chain reaction amplificationTumorsChain reaction amplification
1995
Cell-specific expression of the human Na+,K(+)-ATPase beta 2 subunit isoform in the nonpigmented ciliary epithelium.
Coca-Prados M, Fernández-Cabezudo M, Sánchez-Torres J, Crabb J, Ghosh S. Cell-specific expression of the human Na+,K(+)-ATPase beta 2 subunit isoform in the nonpigmented ciliary epithelium. Investigative Ophthalmology & Visual Science 1995, 36: 2717-28. PMID: 7499094.Peer-Reviewed Original ResearchConceptsBeta 2 isoformNonpigmented ciliary epithelial cellsOcular tissuesCiliary epitheliumBeta 1NPE cell linesNonpigmented ciliary epitheliumNPE cellsHuman ocular tissuesSubunit isoformsBlot analysisATPase subunit isoformsSpecific anti-peptide antibodiesRestricted cellular distributionPolymerase chain reactionCiliary epithelial cellsBeta-subunit isoformsAlpha-subunit isoformsAnti-peptide antibodiesODM-2Polymerase chain reaction amplificationChain reaction amplificationHuman ciliary epitheliumCell-specific distributionPattern of expression
1994
Allelic Variation in the D4 Dopamine Receptor (DRD4) Gene Does Not Predict Response to Clozapine
Rao PA, Pickar D, Gejman PV, Ram A, Gershon ES, Gelernter J. Allelic Variation in the D4 Dopamine Receptor (DRD4) Gene Does Not Predict Response to Clozapine. JAMA Psychiatry 1994, 51: 912-917. PMID: 7944879, DOI: 10.1001/archpsyc.1994.03950110072009.Peer-Reviewed Original ResearchConceptsClinical responseTherapeutic effectAtypical antipsychotic drug clozapineClozapine's therapeutic effectsTreatment-refractory schizophreniaPathophysiology of schizophreniaAntipsychotic drug clozapineD4 dopamine receptorsDRD4 allelesPutative third cytoplasmic loopSchizoaffective patientsTherapeutic responseTherapy variesDopamine receptorsSchizoaffective subjectsTreatment responseThird cytoplasmic loopDrug clozapineClozapineDopamine receptor geneSchizoaffective disorderD4 receptorsPolymerase chain reaction amplificationReceptor allelesChain reaction amplificationRetinal ganglion cells express a cGMP-gated cation conductance activatable by nitric oxide donors
Ahmad I, Leinders-Zufall T, Kocsis J, Shepherd G, Zufall F, Barnstable C. Retinal ganglion cells express a cGMP-gated cation conductance activatable by nitric oxide donors. Neuron 1994, 12: 155-165. PMID: 7507337, DOI: 10.1016/0896-6273(94)90160-0.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-3-isobutylxanthine8-Bromo Cyclic Adenosine MonophosphateAnimalsAnimals, NewbornBase SequenceCells, CulturedCyclic GMPCyclic Nucleotide-Gated Cation ChannelsCysteineDNA PrimersElectric ConductivityGene ExpressionIn Situ HybridizationIon ChannelsMembrane PotentialsModels, NeurologicalMolecular Sequence DataNitric OxideNitroprussidePolymerase Chain ReactionRatsRats, WistarRetinal Ganglion CellsRetinal Rod Photoreceptor CellsS-NitrosothiolsTranscription, GeneticConceptsRetinal ganglion cellsGanglion cellsWhole-cell patch-clamp recordingsRat retinal ganglion cellsNitric oxide donor sodium nitroprussideCation channelsGanglion cell activityPatch-clamp recordingsCation conductanceNitric oxide donorDonor sodium nitroprussideNonselective cation channelsAmacrine cellsSodium nitroprussideOxide donorPhosphodiesterase inhibitorCell activityPolymerase chain reaction amplificationNitric oxideChain reaction amplificationReversal potentialOutward rectificationRod photoreceptorsCGMPS-nitrosocysteine
1992
Variability in nuclear DNA among nonhuman primates: Application of molecular genetic techniques to intra‐ and inter‐species genetic analyses
Rogers J, Ruano G, Kidd K. Variability in nuclear DNA among nonhuman primates: Application of molecular genetic techniques to intra‐ and inter‐species genetic analyses. American Journal Of Primatology 1992, 27: 93-105. PMID: 31948144, DOI: 10.1002/ajp.1350270205.Peer-Reviewed Original ResearchDNA clonesSequence informationMolecular geneticsCross-species PCRIntra-species polymorphismBeta-globin gene clusterNuclear DNA clonesHuman genetic analysisHuman molecular geneticsNucleotide sequence informationNuclear lociGradient gel electrophoresisDNA variationRestriction fragment length polymorphismGene clusterMolecular variabilityGenetic analysisFragment length polymorphismLociLength polymorphismPolymerase chain reaction amplificationGel electrophoresisSpecies differencesGeneticsChain reaction amplification
1991
An insertional frameshift mutation of the beta-spectrin gene associated with elliptocytosis in spectrin nice (beta 220/216).
Tse W, Gallagher P, Pothier B, Costa F, Scarpa A, Delaunay J, Forget B. An insertional frameshift mutation of the beta-spectrin gene associated with elliptocytosis in spectrin nice (beta 220/216). Blood 1991, 78: 517-23. PMID: 2070088, DOI: 10.1182/blood.v78.2.517.bloodjournal782517.Peer-Reviewed Original ResearchAn Insertional Frameshift Mutation of the β-Spectrin Gene Associated With Elliptocytosis in Spectrin Nice (β220 216)
Tse W, Gallagher P, Pothier B, Costa F, Scarpa A, Delaunay J, Forget B. An Insertional Frameshift Mutation of the β-Spectrin Gene Associated With Elliptocytosis in Spectrin Nice (β220 216). Blood 1991, 78: 517-523. DOI: 10.1182/blood.v78.2.517.517.Peer-Reviewed Original Research
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