2023
Investigating CNS distribution of PF‐05212377, a P‐glycoprotein substrate, by translation of 5‐HT6 receptor occupancy from non‐human primates to humans
Sawant‐Basak A, Chen L, Lockwood P, Boyden T, Doran A, Mancuso J, Zasadny K, McCarthy T, Morris E, Carson R, Esterlis I, Huang Y, Nabulsi N, Planeta B, Fullerton T. Investigating CNS distribution of PF‐05212377, a P‐glycoprotein substrate, by translation of 5‐HT6 receptor occupancy from non‐human primates to humans. Biopharmaceutics & Drug Disposition 2023, 44: 48-59. PMID: 36825693, DOI: 10.1002/bdd.2351.Peer-Reviewed Original ResearchConceptsNon-human primatesBrain penetrationPositron emission tomographyReceptor occupancyUnbound concentrationsPre-clinical evidenceVivo brain penetrationConcentration-dependent increaseP-glycoprotein substratesPlasma ECsP-gpAlzheimer's diseaseEmission tomographyRat BBBTarget engagementCumulative evidenceDependent increaseTransporter substratesCNS distributionBBBRatsDiseasePrimatesSpecies differencesHumans
2022
Tracing the cis-regulatory changes underlying the endometrial control of placental invasion
Suhail Y, Maziarz JD, Novin A, Dighe A, Afzal J, Wagner G, Kshitiz. Tracing the cis-regulatory changes underlying the endometrial control of placental invasion. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2111256119. PMID: 35110402, PMCID: PMC8832988, DOI: 10.1073/pnas.2111256119.Peer-Reviewed Original ResearchConceptsCis-regulatory changesComparative genomic investigationCis-regulatory elementsTranscription factor GATA2Placental invasionCancer cell invasionEutherian mammalsTranscription factorsGenomic investigationsInvasibilityGene knockoutGenomic mechanismsDifferent speciesCell invasionEndometrial controlCancer malignancyDegree of invasionSpecies differencesCancer disseminationMaternal endometriumInterspecies differencesPlacental trophoblastsStromal cellsStromal characteristicsInvasion
2021
Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells
Franjic D, Skarica M, Ma S, Arellano JI, Tebbenkamp ATN, Choi J, Xu C, Li Q, Morozov YM, Andrijevic D, Vrselja Z, Spajic A, Santpere G, Li M, Zhang S, Liu Y, Spurrier J, Zhang L, Gudelj I, Rapan L, Takahashi H, Huttner A, Fan R, Strittmatter SM, Sousa AMM, Rakic P, Sestan N. Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells. Neuron 2021, 110: 452-469.e14. PMID: 34798047, PMCID: PMC8813897, DOI: 10.1016/j.neuron.2021.10.036.Peer-Reviewed Original ResearchConceptsDisease-related proteinsCellular diversityCross-species analysisSingle-nucleus transcriptomesLipid droplet proteinsSpecies-specific propertiesImmature neuron populationTranscriptomic taxonomyAlzheimer's disease-related proteinsEndoplasmic reticulumCell typesHuman neuronsSpecies differencesHistologic signatureNeurogenic capabilityProteinExcitatory neuronsDiversityAdult miceGranule cellsAlzheimer's diseaseNeuron populationsCognitive functionEntorhinal cellsAdult humansHominini-specific regulation of CBLN2 increases prefrontal spinogenesis
Shibata M, Pattabiraman K, Muchnik SK, Kaur N, Morozov YM, Cheng X, Waxman SG, Sestan N. Hominini-specific regulation of CBLN2 increases prefrontal spinogenesis. Nature 2021, 598: 489-494. PMID: 34599306, PMCID: PMC9018127, DOI: 10.1038/s41586-021-03952-y.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalcium-Binding ProteinsDendritesEnhancer Elements, GeneticFemaleHumansIntercellular Signaling Peptides and ProteinsMacacaMental DisordersMiceNerve Tissue ProteinsNervous System DiseasesNeural Cell Adhesion MoleculesPhylogenyPrefrontal CortexPromoter Regions, GeneticSOXD Transcription FactorsTranscriptomeUp-RegulationConceptsCerebellin 2Prefrontal cortexCerebral cortex regionsDendritic spine formationInitiation of synaptogenesisLaminar distributionDendritic spinesNervous systemNeuropsychiatric disordersSpine formationLevel of expressionCortex regionsGenetic humanizationCortical gradientsDisproportionate increaseSpecies differencesNeurexinsSpinogenesisDysfunctionMolecular basisPathogenesisExpressionCortexSynaptogenesisSpine
2010
82 Pharmacokinetic–pharmacodynamic modeling of the effect of GDC-0152, a selective antagonist of the inhibitor of apoptosis (IAP) proteins, on monocyte chemotactic protein-1 (MCP-1) indicates species differences in MCP-1 response
Fairbrother W, Wong H, Budha N, Blackwood B, Gould S, Erickson R, LoRusso P, Eckhardt S, Wagner A, Chan I. 82 Pharmacokinetic–pharmacodynamic modeling of the effect of GDC-0152, a selective antagonist of the inhibitor of apoptosis (IAP) proteins, on monocyte chemotactic protein-1 (MCP-1) indicates species differences in MCP-1 response. European Journal Of Cancer Supplements 2010, 8: 34. DOI: 10.1016/s1359-6349(10)71787-0.Peer-Reviewed Original Research
2001
Ion transport and ligand binding by the Na–K–Cl cotransporter, structure–function studies
Isenring P, Forbush B. Ion transport and ligand binding by the Na–K–Cl cotransporter, structure–function studies. Comparative Biochemistry And Physiology Part A Molecular & Integrative Physiology 2001, 130: 487-497. PMID: 11913460, DOI: 10.1016/s1095-6433(01)00420-2.Peer-Reviewed Original ResearchConceptsNa-K-Cl cotransporterK-Cl cotransporterCation-Cl(-) cotransportersC-terminusStructure-function studiesGroups of residuesTransmembrane segmentsMutational approachAnimal cellsCentral domainVariant residuesLigand bindingIon transportDistinct carriersNa-Cl cotransporterResiduesSpecies differencesCotransporterBindingLoop diureticsAnion transportAvailable sulfhydryl groupsSulfhydryl groupsMovement of NaDifferent substrates
2000
Developmental Evolution as a Mechanistic Science: The Inference from Developmental Mechanisms to Evolutionary Processes1
Wagner G, Chiu C, Laubichler M. Developmental Evolution as a Mechanistic Science: The Inference from Developmental Mechanisms to Evolutionary Processes1. Integrative And Comparative Biology 2000, 40: 819-831. DOI: 10.1668/0003-1569(2000)040[0819:deaams]2.0.co;2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsDevelopmental evolutionEvolutionary innovationDevelopmental mechanismsFunction of genesEvolutionary geneticsGenetic architectureEvolutionary originEvolutionary biologyAssessment of homologyDevelopmental dynamicsSpecies differencesBiologyGenetic factorsHomologyGenesMechanismGeneticsSpeciesEvolutionRoleElucidationOriginMechanistic scienceCharacterDevelopmental Evolution as a Mechanistic Science: The Inference from Developmental Mechanisms to Evolutionary Processes1
Wagner G, Chiu C, Laubichler M. Developmental Evolution as a Mechanistic Science: The Inference from Developmental Mechanisms to Evolutionary Processes1. Integrative And Comparative Biology 2000, 40: 819-831. DOI: 10.1093/icb/40.5.819.Peer-Reviewed Original ResearchDevelopmental evolutionEvolutionary innovationDevelopmental mechanismsFunction of genesEvolutionary geneticsGenetic architectureEvolutionary originEvolutionary biologyAssessment of homologyDevelopmental dynamicsSpecies differencesBiologyGenetic factorsHomologyGenesMechanismGeneticsSpeciesEvolutionRoleElucidationOriginMechanistic scienceCharacter
1994
The origin and evolution of species differences in Escherichia coli and Salmonella typhimurium
Ochman H, Groisman EA. The origin and evolution of species differences in Escherichia coli and Salmonella typhimurium. EXS 1994, 69: 479-493. PMID: 7994120, DOI: 10.1007/978-3-0348-7527-1_27.Peer-Reviewed Original ResearchConceptsSpecies-specific sequencesSalmonella chromosomeEscherichia coliCodon usage patternsOpen reading frameHost epithelial cellsCommon ancestorMap positionPhenotypic charactersReading frameBase compositionHorizontal transferSalmonella typhimuriumMutant strainGenetic differencesEnteric speciesBacterial speciesGenomePoint mutationsPhenotypic characteristicsSpeciesCorresponding regionChromosomesSpecies differencesEpithelial cells
1992
Variability in nuclear DNA among nonhuman primates: Application of molecular genetic techniques to intra‐ and inter‐species genetic analyses
Rogers J, Ruano G, Kidd K. Variability in nuclear DNA among nonhuman primates: Application of molecular genetic techniques to intra‐ and inter‐species genetic analyses. American Journal Of Primatology 1992, 27: 93-105. PMID: 31948144, DOI: 10.1002/ajp.1350270205.Peer-Reviewed Original ResearchDNA clonesSequence informationMolecular geneticsCross-species PCRIntra-species polymorphismBeta-globin gene clusterNuclear DNA clonesHuman genetic analysisHuman molecular geneticsNucleotide sequence informationNuclear lociGradient gel electrophoresisDNA variationRestriction fragment length polymorphismGene clusterMolecular variabilityGenetic analysisFragment length polymorphismLociLength polymorphismPolymerase chain reaction amplificationGel electrophoresisSpecies differencesGeneticsChain reaction amplification
1990
Regulation of fetal lung maturation
Gross I. Regulation of fetal lung maturation. American Journal Of Physiology 1990, 259: l337-l344. PMID: 2260669, DOI: 10.1152/ajplung.1990.259.6.l337.Peer-Reviewed Original ResearchConceptsSurfactant proteinsEpithelial cell developmentCell developmentRecent identificationMolecular levelGenesPhospholipid synthesisProteinHormonal regulationSpecies differencesCurrent knowledgeLung developmentRegulationCyclic monophosphateSame hormonesMaturationExpressionPrevious studiesNotable differencesHormoneMonophosphateIdentification
1988
Human Keratinocytes Catabolize Thymidine
Schwartz P, Kugelman L, Coifman Y, Hough L, Milstone L. Human Keratinocytes Catabolize Thymidine. Journal Of Investigative Dermatology 1988, 90: 8-12. PMID: 3335793, DOI: 10.1111/1523-1747.ep12462412.Peer-Reviewed Original ResearchConceptsHuman keratinocytesHuman neonatal foreskinHuman neonatal foreskin keratinocytesNeonatal foreskin keratinocytesCutaneous diseaseSoluble extractsGuinea pigsNeonatal foreskinKeratinocyte proliferationForeskin keratinocytesStratified culturesRate of incorporationAdult skinRadioactive thymidineKeratinocytesThymidine analogueAmount of thymidineExogenous thymidineSpecies differencesThymidineHuman fibroblastsSkinCatabolismDifferent tissuesCulture medium
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