2025
Olfactory bulb interneurons – The developmental timeline and targeting defined by embryonic neurogenesis
Spence N, Martin-Lopez E, Han K, Lefèvre M, Lange N, Brennan B, Greer C. Olfactory bulb interneurons – The developmental timeline and targeting defined by embryonic neurogenesis. Molecular And Cellular Neuroscience 2025, 133: 104007. PMID: 40122272, PMCID: PMC12146071, DOI: 10.1016/j.mcn.2025.104007.Peer-Reviewed Original ResearchGranule cell layerOB interneuronsOlfactory bulbRostral migratory streamEmbryonic interneuronsOlfactory bulb interneuronsMouse olfactory bulbSuperficial granule cell layerLateral ganglionic eminenceOlfactory system functionThymidine analogFormation of circuitsMaternal injectionApical dendritesGanglionic eminenceProgenitor cellsE11-E13Tyrosine hydroxylaseEmbryonic dayInterneuronsMigratory streamPlexiform layerUtero electroporationCell layerEmbryonic neurogenesis
2024
Spiny Keratoderma: Clinical and Histopathological Findings in a Series of 3 Cases
Hanly A, Turner N, Ko C, Panse G. Spiny Keratoderma: Clinical and Histopathological Findings in a Series of 3 Cases. American Journal Of Dermatopathology 2024, 46: 439-442. PMID: 38574081, DOI: 10.1097/dad.0000000000002705.Peer-Reviewed Original Research
2023
A Deep Learning Onion Peeling Approach to Measure Oral Epithelium Layer Number
Zhang X, Gleber-Netto F, Wang S, Jin K, Yang D, Gillenwater A, Myers J, Ferrarotto R, Pickering C, Xiao G. A Deep Learning Onion Peeling Approach to Measure Oral Epithelium Layer Number. Cancers 2023, 15: 3891. PMID: 37568707, PMCID: PMC10416878, DOI: 10.3390/cancers15153891.Peer-Reviewed Original ResearchOral epitheliumNeck squamous cell carcinomaSquamous cell carcinomaPatients' qualityCell carcinomaDysplasia severityEarly diagnosisPathologist's examinationOral cavityComplex cancersClinical relevanceDysplasia diagnosisSurvival analysisEpithelium layerDiagnostic potentialCell layerIntra-observer variationDiagnosisEpitheliumClose correlationPotential additionPrognosisCarcinomaCancerCell cycle controls long-range calcium signaling in the regenerating epidermis
Moore J, Bhaskar D, Gao F, Matte-Martone C, Du S, Lathrop E, Ganesan S, Shao L, Norris R, Sanz N, Annusver K, Kasper M, Cox A, Hendry C, Rieck B, Krishnaswamy S, Greco V. Cell cycle controls long-range calcium signaling in the regenerating epidermis. Journal Of Cell Biology 2023, 222: e202302095. PMID: 37102999, PMCID: PMC10140546, DOI: 10.1083/jcb.202302095.Peer-Reviewed Original Research
2022
Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer
Cockburn K, Annusver K, Gonzalez D, Ganesan S, May D, Mesa K, Kawaguchi K, Kasper M, Greco V. Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer. Nature Cell Biology 2022, 24: 1692-1700. PMID: 36357619, PMCID: PMC9729105, DOI: 10.1038/s41556-022-01021-8.Peer-Reviewed Original ResearchConceptsCell cycle exitCycle exitStem cell layerUndifferentiated stem cellsStem cell compartmentDaughter cellsDifferentiated populationsDifferentiation genesTranscriptional changesCell divisionMultiple progenitorsStemness genesCells transitStem cellsCell compartmentCell layerCell poolDifferentiationRegenerative tissueGenesSkin epidermisGradual differentiationMulti-day processesCellsPodocyte Endocytosis in Regulating the Glomerular Filtration Barrier
Tian X, Bunda P, Ishibe S. Podocyte Endocytosis in Regulating the Glomerular Filtration Barrier. Frontiers In Medicine 2022, 9: 801837. PMID: 35223901, PMCID: PMC8866310, DOI: 10.3389/fmed.2022.801837.Peer-Reviewed Original ResearchPlasma membrane componentsHuman genetic mutationsGlomerular filtration barrierEndocytosis genesEndocytic machineryFiltration barrierTransmembrane receptorsBiological functionsVesicle formationSignaling pathwaysEndocytosisMembrane componentsPodocyte functionCellular endocytosisNovel insightsProteinuric glomerular diseasesAdjacent basement membraneGenetic mutationsFunction studiesEpithelial cellsPathwayEndothelial cell layerBasement membraneImportant roleCell layer
2018
Spine Patterning Is Guided by Segmentation of the Notochord Sheath
Wopat S, Bagwell J, Sumigray KD, Dickson AL, Huitema LFA, Poss KD, Schulte-Merker S, Bagnat M. Spine Patterning Is Guided by Segmentation of the Notochord Sheath. Cell Reports 2018, 22: 2026-2038. PMID: 29466731, PMCID: PMC5860813, DOI: 10.1016/j.celrep.2018.01.084.Peer-Reviewed Original ResearchConceptsNotochord sheathTissue-specific manipulationActivation of NotchZebrafish notochordCentrum formationVertebral patterningOuter epithelial cell layerSheath cellsSegmentation defectsAxial structuresEpithelial cell layerNotochordPatterningIVD areaZebrafish spineDomainCell layerNotchCentraOsteoblastsSheathCellsActivation
2017
Quantitative study of zinc and metallothioneins in the human retina and RPE cells by mass spectrometry-based methodologies
Rodríguez-Menéndez S, Fernández B, García M, Álvarez L, Fernández M, Sanz-Medel A, Coca-Prados M, Pereiro R, González-Iglesias H. Quantitative study of zinc and metallothioneins in the human retina and RPE cells by mass spectrometry-based methodologies. Talanta 2017, 178: 222-230. PMID: 29136815, DOI: 10.1016/j.talanta.2017.09.024.Peer-Reviewed Original ResearchA Cell Culture Model of Resistance Arteries.
Biwer L, Lechauve C, Vanhoose S, Weiss M, Isakson B. A Cell Culture Model of Resistance Arteries. Journal Of Visualized Experiments 2017 PMID: 28930992, PMCID: PMC5752193, DOI: 10.3791/55992.Peer-Reviewed Original ResearchConceptsCell culture modelCell typesMyoendothelial junctionsEndothelial cell polarizationPlating of cellsIntact cell layerDifferent cell typesSignaling microdomainCulture modelSpecific proteinsCell polarizationPhysiological relevanceActivity assaysProtein isolationSmooth muscle cellsVascular cellsMuscle cellsImmunofluorescent analysisIntact resistance arteriesProteinCellsMuscle fractionsIsolationCell layerVCCC
2014
Segregated labeling of olfactory bulb projection neurons based on their birthdates
Imamura F, Greer CA. Segregated labeling of olfactory bulb projection neurons based on their birthdates. European Journal Of Neuroscience 2014, 41: 147-156. PMID: 25393912, PMCID: PMC4300262, DOI: 10.1111/ejn.12784.Peer-Reviewed Original ResearchConceptsExternal plexiform layerMitral cell layerOlfactory bulb projection neuronsSuperficial external plexiform layerProjection neuronsMitral cellsOlfactory bulbInnervation patternSoma locationOB projection neuronsMain olfactory bulbAccessory olfactory bulbMouse olfactory bulbTiming of neurogenesisSecondary dendritesPlexiform layerCell dendritesBrdU injectionLaminar organizationUtero electroporationNeuronsDistinct subsetsEmbryonic dayCell layerMitral
2012
Radial Construction of an Arterial Wall
Greif DM, Kumar M, Lighthouse JK, Hum J, An A, Ding L, Red-Horse K, Espinoza FH, Olson L, Offermanns S, Krasnow MA. Radial Construction of an Arterial Wall. Developmental Cell 2012, 23: 482-493. PMID: 22975322, PMCID: PMC3500096, DOI: 10.1016/j.devcel.2012.07.009.Peer-Reviewed Original ResearchConceptsInner layer cellsCoordinated processGenetic analysisSuccessive cell layersVessel-specific differencesSignaling pathwaysCell reorientationSequential inductionEndothelial tubesSignal gradientMuscle cellsSignal contributesSerious diseaseCellsCell layerLayer cellsRadial migrationMesenchymeConcentric layersPathwayArterial wallPDGFInvasionInductionArtery wallPostnatal characterization of cells in the accessory olfactory bulb of wild type and reeler mice
Martín-López E, Corona R, López-Mascaraque L. Postnatal characterization of cells in the accessory olfactory bulb of wild type and reeler mice. Frontiers In Neuroanatomy 2012, 6: 15. PMID: 22661929, PMCID: PMC3357593, DOI: 10.3389/fnana.2012.00015.Peer-Reviewed Original ResearchAccessory olfactory bulbOlfactory bulbReeler miceCell phenotypeAdaptor protein Dab1Early postnatal developmentGranular cell layerOlfactory systemAccessory olfactory systemGlial cell typesMain olfactory systemWT miceReelin deficiencyGlial markersGranular neuronsPostnatal developmentLearning deficitsMiceCell layerFirst relayCell typesEarly embryonic stagesBulbPhenotypeGenetic background
2011
Homozygosity mapping and targeted genomic sequencing reveal the gene responsible for cerebellar hypoplasia and quadrupedal locomotion in a consanguineous kindred
Gulsuner S, Tekinay AB, Doerschner K, Boyaci H, Bilguvar K, Unal H, Ors A, Onat OE, Atalar E, Basak AN, Topaloglu H, Kansu T, Tan M, Tan U, Gunel M, Ozcelik T. Homozygosity mapping and targeted genomic sequencing reveal the gene responsible for cerebellar hypoplasia and quadrupedal locomotion in a consanguineous kindred. Genome Research 2011, 21: 1995-2003. PMID: 21885617, PMCID: PMC3227090, DOI: 10.1101/gr.126110.111.Peer-Reviewed Original ResearchConceptsBeta-propeller domainPrivate missense mutationsLarge consanguineous familyThird geneBEACH domainTransmembrane proteinHomozygous regionsHomozygosity mappingGenomic sequencingWDR81Chromosome 17p13.1Missense mutationsQuadrupedal locomotionConsanguineous familyTargeted sequencingGenesSequencingRare phenotypeMorphological abnormalitiesBiological basisMutationsAffected individualsCell layerParticular atrophyFamilyPosthypoxic Moderate Hypothermia Improves Electrophysiological Recovery in the Rat Hippocampal Slice
Charchaflieh JG, Torres H, Cottrell JE, Kass IS. Posthypoxic Moderate Hypothermia Improves Electrophysiological Recovery in the Rat Hippocampal Slice. Journal Of Neurosurgical Anesthesiology 2011, 23: 146-149. PMID: 21270645, DOI: 10.1097/ana.0b013e31820592d1.Peer-Reviewed Original ResearchConceptsMinutes of hypoxiaRat hippocampal slicesPosthypoxic hypothermiaElectrophysiological recoveryModerate hypothermiaHippocampal slicesCA1 pyramidal cell layerMale Sprague-Dawley ratsHypoxic neuronal injuryPyramidal cell layerSprague-Dawley ratsHours of recoveryNeuronal injuryProtective effectStudy groupInstitutional Animal CareAnimal studiesControl groupHypothermiaElectrophysiological recordingsHypoxiaCell functionUse CommitteeCell layerAnimal care
2010
Astroglial cells in the external granular layer are precursors of cerebellar granule neurons in neonates
Silbereis J, Heintz T, Taylor MM, Ganat Y, Ment LR, Bordey A, Vaccarino F. Astroglial cells in the external granular layer are precursors of cerebellar granule neurons in neonates. Molecular And Cellular Neuroscience 2010, 44: 362-373. PMID: 20470892, PMCID: PMC2900521, DOI: 10.1016/j.mcn.2010.05.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAstrocytesBasic Helix-Loop-Helix Transcription Factorsbeta-GalactosidaseCell LineageCerebellumGenes, ReporterGlial Fibrillary Acidic ProteinGreen Fluorescent ProteinsIntegrasesMiceMice, Inbred C57BLMice, TransgenicNeurogenesisNeuronsPromoter Regions, GeneticStem CellsTime FactorsConceptsExternal granule cell layerGranule cell precursorsInternal granule cell layerGranule cell layerGranule cellsRhombic lipAstroglial cellsProtein expression profilesGlial fibrillary acidic protein promoterCerebellar granule cell precursorsHuman glial fibrillary acidic protein promoterEmbryonic rhombic lipInducible Cre recombinaseNeuronal progenitor cellsReporter proteinFirst postnatal weekNeural stem cell markersLate embryogenesisCellular plasticityImmature granule cellsEarly postnatal developmentCell layerReporter geneCerebellar granule neuronsStem cell markers
2009
Localization of Multidrug Resistance-Associated Protein 2 in the Nonpigmented Ciliary Epithelium of the Eye
Pelis RM, Shahidullah M, Ghosh S, Coca-Prados M, Wright SH, Delamere NA. Localization of Multidrug Resistance-Associated Protein 2 in the Nonpigmented Ciliary Epithelium of the Eye. Journal Of Pharmacology And Experimental Therapeutics 2009, 329: 479-485. PMID: 19201990, PMCID: PMC2672870, DOI: 10.1124/jpet.108.149625.Peer-Reviewed Original ResearchConceptsNonpigmented epitheliumMicroM MK571Ciliary bodyMultidrug resistance associated protein 2Therapeutic drugsMrp2 proteinIntracellular accumulationBlood-aqueous barrierNonpigmented ciliary epitheliumProtein 2Human ciliary bodyMicroM indomethacinMRP inhibitorsIntraocular tissuesAqueous humorApical membraneMRP2 mRNAWestern blotMultidrug resistanceCiliary epitheliumMicroM cyclosporinPorcine eyesMRP2Cell layerNative human
2008
Circumscribed palmar hypokeratosis: two cases and a review of the literature
Barry CI, Glusac EJ, Kashgarian M, Gwin K, McNiff JM. Circumscribed palmar hypokeratosis: two cases and a review of the literature. Journal Of Cutaneous Pathology 2008, 35: 484-487. PMID: 18399810, DOI: 10.1111/j.1600-0560.2007.00835.x.Peer-Reviewed Original Research
2004
Inhibition of NHE-1 Na+/H+ exchanger by natriuretic peptides in ocular nonpigmented ciliary epithelium
Fidzinski P, Salvador-Silva M, Choritz L, Geibel J, Coca-Prados M. Inhibition of NHE-1 Na+/H+ exchanger by natriuretic peptides in ocular nonpigmented ciliary epithelium. American Journal Of Physiology - Cell Physiology 2004, 287: c655-c663. PMID: 15140751, DOI: 10.1152/ajpcell.00552.2003.Peer-Reviewed Original ResearchConceptsC-type natriuretic peptideAtrial natriuretic peptideBrain natriuretic peptideNatriuretic peptideIntraocular pressureCiliary epitheliumNHE activityNatriuretic peptides atrial natriuretic peptideInhibitory effectType B receptorsNHE-1 activityNonpigmented ciliary epitheliumCell layerGap junction blockersDose-dependent mannerInhibitors of NHEOcular ciliary epitheliumRate of intracellularHypotensive effectJunction blockersTrabecular meshworkMammalian eyeExchanger activityB receptorNHE-1
2002
GABABR1 receptor protein expression in human mesial temporal cortex: Changes in temporal lobe epilepsy
Muñoz A, Arellano J, Defelipe J. GABABR1 receptor protein expression in human mesial temporal cortex: Changes in temporal lobe epilepsy. The Journal Of Comparative Neurology 2002, 449: 166-179. PMID: 12115687, DOI: 10.1002/cne.10287.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyHuman hippocampal formationLayer VHippocampal formationLobe epilepsyB immunoreactivityDentate gyrusPyramidal cellsEpileptic patientsPerirhinal cortexProtein expressionInhibitory synaptic transmissionLarge pyramidal cellsMesial temporal cortexPolymorphic cell layerDeep layer VReceptor protein expressionGranule cell layerCell layerAdjacent cortical structuresB protein expressionHippocampal sclerosisNeuronal lossApical dendritesAmmon's horn
2000
Accelerated Healing of Full-Thickness Skin Wounds in a Wet Environment
Svensjö T, Pomahac B, Yao F, Slama J, Eriksson E. Accelerated Healing of Full-Thickness Skin Wounds in a Wet Environment. Plastic & Reconstructive Surgery 2000, 106: 602-612. DOI: 10.1097/00006534-200009030-00012.Peer-Reviewed Original ResearchFull-thickness skin woundsSkin woundsAccelerated healingSaline-treated woundsGranulation tissue formationYoung Yorkshire pigsSecondary intentionTreatment modalitiesWound healing processSkin wound repairGranulation tissueWound healing modelWound contractionStandardized fashionPorcine wound healing modelFast contractionHealing processWound repairWoundsCell layerYorkshire pigsMoist woundSkin repairHealing modelHealing
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