2004
The utility of immunohistochemical detection of DNA mismatch repair gene proteins
Shia J, Ellis N, Klimstra D. The utility of immunohistochemical detection of DNA mismatch repair gene proteins. Virchows Archiv 2004, 445: 431-441. PMID: 15455227, DOI: 10.1007/s00428-004-1090-5.Peer-Reviewed Original ResearchConceptsGene proteinMismatch repairDNA mismatch repairSporadic colorectal tumorsMSH2 proteinProteinMismatch repair proteinsDetection of MMR proteinsMismatch repair gene proteinsMicrosatellite instabilityPublished research studiesImmunohistochemical detectionMMR proteinsMonoclonal antibodiesMicrosatelliteClinical settingDevelopment of monoclonal antibodiesPatient population
2001
Persistent Productive Epstein-Barr Virus Replication in Normal Epithelial Cells In Vivo
Walling D, Flaitz C, Nichols C, Hudnall S, Adler-Storthz K. Persistent Productive Epstein-Barr Virus Replication in Normal Epithelial Cells In Vivo. The Journal Of Infectious Diseases 2001, 184: 1499-1507. PMID: 11740724, DOI: 10.1086/323992.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusEpstein-Barr virus replicationHairy leukoplakiaEBV replicationValacyclovir treatmentVirus replicationNormal tongue tissuesPersistent EBV infectionProductive EBV replicationReverse transcriptase-polymerase chain reaction amplificationOral hairy leukoplakiaEpithelial cellsOral epithelial lesionsTongue epithelial cellsEBV infectionNormal epithelial cellsEBV DNAImmunodeficiency virusBiopsy specimensEpithelial lesionsImmunohistochemical detectionLeukoplakiaPolymerase chain reaction amplificationTongue tissueChain reaction amplificationThe generation, migration, and differentiation of olfactory neurons in the adult primate brain
Kornack D, Rakic P. The generation, migration, and differentiation of olfactory neurons in the adult primate brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 4752-4757. PMID: 11296302, PMCID: PMC31906, DOI: 10.1073/pnas.081074998.Peer-Reviewed Original ResearchConceptsRostral migratory streamOlfactory bulbAdult primate brainAdult macaque monkeysNeural progenitor cellsSmaller olfactory bulbsAdult rodentsSubependymal zoneImmunohistochemical detectionPrimate brainMacaque monkeysOlfactory neuronsMigratory streamNonhuman primatesProgenitor cellsRegenerative mechanismsInterneuronsHuman brainBrainNeuroblastsCellsNeurons
1999
Hidden Mortality Attributable to Rocky Mountain Spotted Fever: Immunohistochemical Detection of Fatal, Serologically Unconfirmed Disease
Paddock C, Greer P, Ferebee T, Singleton J, McKechnie D, Treadwell T, Krebs J, Clarke M, Holman R, Olson J, Childs J, Zaki S. Hidden Mortality Attributable to Rocky Mountain Spotted Fever: Immunohistochemical Detection of Fatal, Serologically Unconfirmed Disease. The Journal Of Infectious Diseases 1999, 179: 1469-1476. PMID: 10228069, DOI: 10.1086/314776.Peer-Reviewed Original ResearchConceptsCase fatality ratioDiagnosis of RMSFIHC stainingRocky Mountain Spotted FeverLaboratory-confirmed casesAcute-phase seraTickborne infectionHidden mortalityIgM antibodiesDiagnostic titerPolymerase chain reactionIHC findingsPatient seraSerologic assaysImmunohistochemical stainingSpotted FeverImmunohistochemical detectionFatal diseasePatientsDisease controlIndirect immunofluorescenceNotifiable diseaseDiseaseUnderestimates of mortalityTissue samples
1995
Immunohistochemical detection of advanced glycosylation end products within the vascular lesions and glomeruli in diabetic nephropathy
Nishino T, Horii Y, Shiiki H, Yamamoto H, Makita Z, Bucala R, Dohi K. Immunohistochemical detection of advanced glycosylation end products within the vascular lesions and glomeruli in diabetic nephropathy. Human Pathology 1995, 26: 308-313. PMID: 7890283, DOI: 10.1016/0046-8177(95)90063-2.Peer-Reviewed Original ResearchConceptsAdvanced glycosylation end productsGlycosylation end productsSevere diffuse lesionsAnti-AGE antibodyComplications of diabetesInner elastic layerRenal complicationsDiabetic nephropathyAGE antibodyDiffuse lesionsNondiabetic individualsVascular lesionsPathogenic roleAGE accumulationHyaline depositsImmunohistochemical stainingPositive stainingImmunohistochemical detectionAdvanced glycosylationVascular intimaNormal agingSpecific antibodiesTissue distributionEnd productsAntibodies
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