2024
Cell Growth Trajectories of B-Cell Lymphomas Are Defined By Oscillations between MYC- and BCL6-Dependent States
Cheng Z, Kume K, Shanmugam V, Müschen M. Cell Growth Trajectories of B-Cell Lymphomas Are Defined By Oscillations between MYC- and BCL6-Dependent States. Blood 2024, 144: 45-45. DOI: 10.1182/blood-2024-206563.Peer-Reviewed Original ResearchActivation of MYCCell divisionCell growthDNA damage-induced apoptosisTurnover of damaged organellesB-cell lymphomaTranscriptional activity of MYCChIP-seq dataDamage-induced apoptosisOscillatory expression patternsCell shrinkageDegradation of MycPhenotype to cellsTranscription of MYCInduce transcriptional activationAmino acid depletionTime-lapse confocal imagingLive-cell imagingStall cell growthB cell developmentChIP-seqB cellsDegron systemRepress transcriptionCell size
2021
Chapter 5 Protocols in apoptosis identification and affirmation
Jamwal S, Kumar P, Kakkar V, Kumari P, Chahal S. Chapter 5 Protocols in apoptosis identification and affirmation. 2021, 127-152. DOI: 10.1016/b978-0-12-815762-6.00005-6.Peer-Reviewed Original ResearchCell deathApoptosis researchDeath-signaling pathwaysCell cycle mechanismsPathways of introductionRegulatory genesMembrane blebbingCell divisionChromatin condensationCell cycleApoptotic bodiesCell shrinkageRemoval of cellsNormal homeostasisApoptosisSpecific activationNeurodegenerative diseasesPathwayApoptosis quantificationCycle mechanismIndividual morphological featuresDiseased conditionsBiomedical researchDisease statesDrug development
2014
The Putative Role of the Non-Gastric H+/K+-ATPase ATP12A (ATP1AL1) as Anti-Apoptotic Ion Transporter: Effect of the H+/K+ ATPase Inhibitor SCH28080 on Butyrate-Stimulated Myelomonocytic HL-60 Cells
Jakab M, Hofer S, Ravasio A, Huber F, Schmidt S, Hitzl W, Geibel JP, Fürst J, Ritter M. The Putative Role of the Non-Gastric H+/K+-ATPase ATP12A (ATP1AL1) as Anti-Apoptotic Ion Transporter: Effect of the H+/K+ ATPase Inhibitor SCH28080 on Butyrate-Stimulated Myelomonocytic HL-60 Cells. Cellular Physiology And Biochemistry 2014, 34: 1507-1526. PMID: 25322912, DOI: 10.1159/000366355.Peer-Reviewed Original ResearchConceptsIntracellular acid loadHL-60 cellsAcute intracellular acid loadAcid loadMCV measurementsOsmotic cell shrinkageReal-time reverse transcription PCREarly apoptosisChanges of intracellularCD86 expressionFlow cytometric determinationReverse transcription-PCRBACKGROUND/Intracellular acidosisLoss of intracellularCell shrinkageHigher MCVFlow cytometryRT-PCRATP12APhosphatidylserine exposureUntreated cellsPotential roleMCVApoptosis
2012
The role of hyperosmotic stress in inflammation and disease
Brocker C, Thompson DC, Vasiliou V. The role of hyperosmotic stress in inflammation and disease. BioMolecular Concepts 2012, 3: 345-364. PMID: 22977648, PMCID: PMC3438915, DOI: 10.1515/bmc-2012-0001.Peer-Reviewed Original ResearchHyperosmotic stressNon-renal tissuesCell cycle arrestHigh extracellular osmolarityOsmolyte synthesisCytoskeletal rearrangementsRegulatory pathwaysMitochondrial depolarizationShock proteinsHyperosmotic conditionsHuman diseasesCell shrinkageDNA damageMammalian kidneyCycle arrestInner medullary regionProtein carbonylationCytoprotective mechanismsExtracellular osmolarityConcentrating mechanismAntioxidant enzymesAdaptive mechanismsPhysiological conditionsPathological consequencesOxidative stress
1997
Techniques for Distinguishing Apoptosis from Necrosis in Cerebrocortical and Cerebellar Neurons
Bonfoco E, Ankarcrona M, Krainc D, Nicotera P, Lipton S. Techniques for Distinguishing Apoptosis from Necrosis in Cerebrocortical and Cerebellar Neurons. Neuromethods 1997, 29: 237-253. DOI: 10.1385/0-89603-451-8:237.Peer-Reviewed Original ResearchCell deathCell typesRegulated cell deathDifferent cell typesSame cell typeApoptotic stimuliMorphological criteriaChromatin condensationChromatin degradationCleavage of DNADetection of apoptosisCell shrinkageApoptosisApoptotic cellsImmature T lymphocytesCerebellar neuronsMorphological alterationsAPO1Light microscopyMorphological patternsDNAMorphological appearanceExponential growthDifferent morphological patternsT cells
1996
Prostaglandin E2 Stimulates a Ca2+-dependent K+ Channel in Human Erythrocytes and Alters Cell Volume and Filterability*
Li Q, Jungmann V, Kiyatkin A, Low P. Prostaglandin E2 Stimulates a Ca2+-dependent K+ Channel in Human Erythrocytes and Alters Cell Volume and Filterability*. Journal Of Biological Chemistry 1996, 271: 18651-18656. PMID: 8702518, DOI: 10.1074/jbc.271.31.18651.Peer-Reviewed Original ResearchConceptsProstaglandin E2Red blood cellsRelease of PGE2Efflux pathwayGardos channel inhibitorGardos channel activationM. Prostaglandin E2PGE2 treatmentIntact red blood cellsHuman erythrocytesMean cell volumeChannel inhibitorsClot formationEffects of metabolitesCell shrinkageGardos channelHuman red blood cellsNa/K/2Cl cotransportBlood cellsOsmotic fragilityChannel activationRed cellsPossible involvementPlateletsCell volumeRegulatory phosphorylation of the secretory Na-K-Cl cotransporter: modulation by cytoplasmic Cl
Lytle C, Forbush B. Regulatory phosphorylation of the secretory Na-K-Cl cotransporter: modulation by cytoplasmic Cl. American Journal Of Physiology 1996, 270: c437-c448. PMID: 8779905, DOI: 10.1152/ajpcell.1996.270.2.c437.Peer-Reviewed Original ResearchConceptsNa-K-Cl cotransporterNa-K-ClCotransport activityNa-K-Cl cotransport proteinResponse to cell shrinkageIncreased cotransport activityExtracellular K concentrationBlocking activityRefractory to forskolinPhosphatase inhibitor calyculin AInhibitor calyculin AShark rectal glandCotransporter proteinCytoplasmic Cl-CotransporterCell ClSecretory stimuliCell shrinkageCalyculin APhosphorylationRate of entryRegulatory phosphorylationPhosphorylation stateSecretory tubulesRectal glandCrocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro
Escribano J, Alonso G, Coca-Prados M, Fernández J. Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Letters 1996, 100: 23-30. PMID: 8620447, DOI: 10.1016/0304-3835(95)04067-6.Peer-Reviewed Original ResearchConceptsExtract of saffronCytotoxic effectsCell growth inhibitionCancer therapeutic agentsHuman tumor cellsHuman cancer cellsPyknotic nucleiInhibitory growth effectTherapeutic agentsTumor cellsCancer cellsEthanolic extractApoptosis inductionCrocinGrowth inhibitionReduced cytoplasmCell growthCellsCrocetinCell shrinkageDosesHeLa cells
1992
The Na-K-Cl cotransport protein of shark rectal gland. II. Regulation by direct phosphorylation.
Lytle C, Forbush B. The Na-K-Cl cotransport protein of shark rectal gland. II. Regulation by direct phosphorylation. Journal Of Biological Chemistry 1992, 267: 25438-25443. PMID: 1334094, DOI: 10.1016/s0021-9258(19)74060-5.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCarrier ProteinsChromatography, High Pressure LiquidCyclic AMPDogfishHypertonic SolutionsIsoquinolinesKineticsMembrane ProteinsMolecular Sequence DataPeptide FragmentsPhosphorylationProtein Kinase InhibitorsRectumSebaceous GlandsSodium-Potassium-Chloride SymportersSulfanilamidesThionucleotidesConceptsNa-K-Cl cotransport proteinNa-K-ClCotransporter proteinShark rectal glandCell shrinkageCAMP-dependent secretagoguesRectal gland tubulesOsmotically induced changesCotransporter phosphorylationCotransport activityKinase inhibitorsProtein kinase inhibitorsCotransporterPhosphorylation stateRectal glandActive stateH-8K-252aTubulesGlandPhosphorylationCDNA analysisCellsIncreased 5Protein phosphorylationNa-K-Cl cotransport in the shark rectal gland. II. Regulation in isolated tubules
Lytle C, Forbush B. Na-K-Cl cotransport in the shark rectal gland. II. Regulation in isolated tubules. American Journal Of Physiology 1992, 262: c1009-c1017. PMID: 1314482, DOI: 10.1152/ajpcell.1992.262.4.c1009.Peer-Reviewed Original ResearchConceptsNa-K-Cl cotransporterNa-K-ClShark rectal glandInhibitor of Na-K-Cl cotransportApical Cl- channelsCell shrinkageEffects of secretagoguesOsmotically induced changesSensitivity to cAMPCl- channelsExtracellular sodiumIsolated tubulesCotransporterHormonal modulationSecretory stimuliSignal transduction pathwaysSecretagoguesRectal glandTubulesRectal gland secretionHypertonicityCell volumeTransduction pathwaysGlandCells
1986
[3H]bumetanide binding to duck red cells. Correlation with inhibition of (Na + K + 2Cl) co-transport.
Haas M, Forbush B. [3H]bumetanide binding to duck red cells. Correlation with inhibition of (Na + K + 2Cl) co-transport. Journal Of Biological Chemistry 1986, 261: 8434-8441. PMID: 3013852, DOI: 10.1016/s0021-9258(19)83931-5.Peer-Reviewed Original ResearchConceptsDuck red cellsExtracellular sodiumRed cellsCo-transportDog kidney outer medullaBinding of [3H]bumetanideConcentration of extracellular sodiumIncreased extracellular sodiumPresence of norepinephrineCo-transport systemBumetanide inhibitionKidney outer medullaOuter medullaBiphasic effectInhibition of influxCell shrinkageHalf-maximalSaturable bindingBumetanideInhibit bindingCell typesSaturable mannerNorepinephrineInfluxBinding to membranes
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