2024
HEXIM1 Regulates Early Erythropoiesis and Participates in Multiple Complexes in Erythroid Cells
Rahman N, Abid D, Lv X, Murphy K, Getman M, McGrath K, Gallagher P, Narla M, Blanc L, Palis J, Mello S, Steiner L. HEXIM1 Regulates Early Erythropoiesis and Participates in Multiple Complexes in Erythroid Cells. Blood 2024, 144: 536. DOI: 10.1182/blood-2024-209259.Peer-Reviewed Original ResearchRNA polymerase IIErythroid gene expressionGene expressionTerminal erythroid maturationEarly erythropoiesisErythroid cellsErythroid maturationRegulation of gene expressionProgenitor cellsImpaired erythroid differentiationRNAPII pausingGenomic contextPolymerase IIRepress transcriptionSteady-state erythropoiesisErythroid progenitor cellsCD34+ HSPCsRegulatory domainBinding partnersErythropoiesis in vivoBlood cell countColony-forming cellsLow red blood cell countSubnuclear bodiesErythroid progenitor differentiationCell Growth Trajectories of B-Cell Lymphomas Are Defined By Oscillations between MYC- and BCL6-Dependent States
Cheng Z, Kume K, Shanmugam V, Müschen M. Cell Growth Trajectories of B-Cell Lymphomas Are Defined By Oscillations between MYC- and BCL6-Dependent States. Blood 2024, 144: 45-45. DOI: 10.1182/blood-2024-206563.Peer-Reviewed Original ResearchActivation of MYCCell divisionCell growthDNA damage-induced apoptosisTurnover of damaged organellesB-cell lymphomaTranscriptional activity of MYCChIP-seq dataDamage-induced apoptosisOscillatory expression patternsCell shrinkageDegradation of MycPhenotype to cellsTranscription of MYCInduce transcriptional activationAmino acid depletionTime-lapse confocal imagingLive-cell imagingStall cell growthB cell developmentChIP-seqB cellsDegron systemRepress transcriptionCell size
2013
Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain
Guo J, Su Y, Shin J, Shin J, Li H, Xie B, Zhong C, Hu S, Le T, Fan G, Zhu H, Chang Q, Gao Y, Ming G, Song H. Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain. Nature Neuroscience 2013, 17: 215-222. PMID: 24362762, PMCID: PMC3970219, DOI: 10.1038/nn.3607.Peer-Reviewed Original ResearchConceptsCpH methylationNon-CpG cytosinesNon-CpG methylationSingle-base resolutionDNA methylome profilingDNA methyltransferase DNMT3ARepress transcriptionCpG dinucleotidesMethyltransferase DNMT3AProtein MeCP2DNANeuronal maturationMethylationMammalian brainDentate gyrus neuronsAdult mammalian brainCpGTranscriptionDinucleotide
2002
Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter
KACZYNSKI J, CONLEY A, ZAPICO M, DELGADO S, ZHANG J, URRUTIA R. Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter. Biochemical Journal 2002, 366: 873-882. PMID: 12036432, PMCID: PMC1222816, DOI: 10.1042/bj20020388.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBlotting, NorthernBlotting, WesternCarcinogensCell Cycle ProteinsCell LineCHO CellsChromatinCricetinaeCytochrome P-450 CYP1A1DNA, ComplementaryDNA-Binding ProteinsDose-Response Relationship, DrugGlutathione TransferaseHumansKruppel-Like Transcription FactorsMolecular Sequence DataPlasmidsPromoter Regions, GeneticProtein BindingProtein Structure, TertiaryRecombinant Fusion ProteinsRepressor ProteinsSequence Homology, Amino AcidSp1 Transcription FactorTrans-ActivatorsTranscription FactorsTranscription, GeneticZinc FingersConceptsGene promoterCYP1A1 gene promoterProtein familyC-terminal zinc-finger motifC-terminal zinc-finger domainBind GC-rich sequencesControl of gene expressionCo-repressor mSin3ASp1-like proteinsZinc-finger motifGC-rich sequencesFamily of proteinsN-terminal regionRepress transcriptionTranscriptional repressionCo-repressorTranscriptional repressorCellular machineryExpressed memberTranscriptional elementsTranscription factorsFunctional characterizationBTEB3Gene expressionTranscription
2001
A Conserved α-Helical Motif Mediates the Interaction of Sp1-Like Transcriptional Repressors with the Corepressor mSin3A
Zhang J, Moncrieffe M, Kaczynski J, Ellenrieder V, Prendergast F, Urrutia R. A Conserved α-Helical Motif Mediates the Interaction of Sp1-Like Transcriptional Repressors with the Corepressor mSin3A. Molecular And Cellular Biology 2001, 21: 5041-5049. PMID: 11438660, PMCID: PMC87230, DOI: 10.1128/mcb.21.15.5041-5049.2001.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAmino Acid SequenceAnimalsApoptosis Regulatory ProteinsBlotting, WesternCell Cycle ProteinsCell DivisionCHO CellsCircular DichroismCricetinaeGenetic VectorsGlutathione TransferaseLuciferasesMolecular Sequence DataMutationPeptide BiosynthesisPlasmidsPrecipitin TestsProtein BindingProtein BiosynthesisProtein Structure, TertiaryRecombinant Fusion ProteinsRepressor ProteinsSequence Homology, Amino AcidSin3 Histone Deacetylase and Corepressor ComplexSp1 Transcription FactorTranscription, GeneticTransforming Growth Factor betaZinc FingersConceptsSp1-like proteinsRepress transcriptionDeacetylase complexRepression motifTranscriptional repressionSin3 histone deacetylase complexBind GC-rich sequencesMechanism of transcriptional repressionSp1-like transcription factorsMSin3A-histone deacetylase complexGC-rich sequencesMammalian cell homeostasisCorepressor mSin3ARepression domainTranscriptional repressorA-helicesMSin3ATranscription factorsTIEG2Antiproliferative functionCell homeostasisMotifTranscriptionRepressionProtein
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