2017
Bok Promotes Erythropoiesis in a Mouse Model of Myelodysplastic Syndrome
Kang S, Perales O, Michuad M, Katz S. Bok Promotes Erythropoiesis in a Mouse Model of Myelodysplastic Syndrome. Blood 2017, 130: 922. DOI: 10.1182/blood.v130.suppl_1.922.922.Peer-Reviewed Original ResearchAcute myeloid leukemiaNHD13 miceMean cell hemoglobin concentrationMouse modelBone marrowMean cell volumeMDS/acute myeloid leukemiaRBC progenitorsUnfolded protein responseSimilar overall survivalTransgenic mouse modelPathogenesis of myelodysplasiaER stressHigher mean cell volumeLower mean cell hemoglobin concentrationCell hemoglobin concentrationAnti-apoptotic Bcl-2Endoplasmic reticulum stressOverall survivalProgenitor stem cellsRed blood cellsLower hemoglobinMyelodysplastic syndromeMyeloid leukemiaRegulation of erythropoiesis
1996
Prostaglandin E2 Stimulates a Ca2+-dependent K+ Channel in Human Erythrocytes and Alters Cell Volume and Filterability*
Li Q, Jungmann V, Kiyatkin A, Low P. Prostaglandin E2 Stimulates a Ca2+-dependent K+ Channel in Human Erythrocytes and Alters Cell Volume and Filterability*. Journal Of Biological Chemistry 1996, 271: 18651-18656. PMID: 8702518, DOI: 10.1074/jbc.271.31.18651.Peer-Reviewed Original ResearchConceptsProstaglandin E2Red blood cellsRelease of PGE2Efflux pathwayGardos channel inhibitorGardos channel activationM. Prostaglandin E2PGE2 treatmentIntact red blood cellsHuman erythrocytesMean cell volumeChannel inhibitorsClot formationEffects of metabolitesCell shrinkageGardos channelHuman red blood cellsNa/K/2Cl cotransportBlood cellsOsmotic fragilityChannel activationRed cellsPossible involvementPlateletsCell volume
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