2025
Characterizing the ADPKD-IFT140 Phenotypic Signature with Deep Learning and Advanced Imaging Biomarkers
Ghanem A, Debeh F, Borghol A, Zagorec N, Tapia A, Smith B, Paul S, Basit A, AlKhatib B, Nader N, Antoun M, Gregory A, Yang H, Schauer R, Dahl N, Hanna C, Torres V, Kline T, Harris P, Gall E, Chebib F. Characterizing the ADPKD-IFT140 Phenotypic Signature with Deep Learning and Advanced Imaging Biomarkers. Kidney International Reports 2025 DOI: 10.1016/j.ekir.2025.04.062.Peer-Reviewed Original ResearchArea under the curveHeight-adjusted total kidney volumeAutosomal dominant polycystic kidney diseaseEstimated glomerular filtrationDisease-causing variantsDevelopment cohortAdvanced imaging biomarkersTotal kidney volumeDominant polycystic kidney diseaseRetrospective cohort studyPolycystic kidney diseaseClinical presentationCyst volumeKidney volumeCyst diameterCystic indexDiverse clinical settingsLiver cystsCohort studyExternal cohortKidney diseaseLarge cystsInternational cohortGlomerular filtrationPatients
2024
Toxic Nephropathies of the Tubulointerstitium: Core Curriculum 2024
Krishnan N, Moledina D, Perazella M. Toxic Nephropathies of the Tubulointerstitium: Core Curriculum 2024. American Journal Of Kidney Diseases 2024, 83: 659-676. PMID: 38243994, DOI: 10.1053/j.ajkd.2023.09.017.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsRenal injurySeverity of renal injuryToxic nephropathyTubulointerstitial renal injuryIrreversible renal injuryToxin-induced renal injuryImmune response genesNephrotoxic riskClinical presentationTubulointerstitial injuryRenal functionClinical manifestationsPatient characteristicsTubular secretionGlomerular filtrationComorbid conditionsMetabolic handlingDrug metabolismExcretory pathwayInjuryTransport defectAdverse effectsTubulointerstitiumNephropathyExogenous toxins
2022
Classic and Novel Mechanisms of Diuretic Resistance in Cardiorenal Syndrome
Cox ZL, Rao VS, Testani JM. Classic and Novel Mechanisms of Diuretic Resistance in Cardiorenal Syndrome. Kidney360 2022, 3: 954-967. PMID: 36128483, PMCID: PMC9438407, DOI: 10.34067/kid.0006372021.Commentaries, Editorials and LettersConceptsCardiorenal syndromeDiuretic resistanceSodium avidityAcute decompensated heart failureDecompensated heart failureRenal sodium avidityHeart failure phenotypeResistance mechanismsDiuretic therapyHeart failureFailure populationNovel mechanismMultiple etiologiesGlomerular filtrationTherapeutic strategiesFailure phenotypeSyndromeTranslate findingsAviditySpecific transportersTherapyEtiologyPopulationRecent literature
2021
Pediatric Nephrotic Syndrome: Pharmacologic and Nutrition Management
Hampson K, Gay M, Band M. Pediatric Nephrotic Syndrome: Pharmacologic and Nutrition Management. Nutrition In Clinical Practice 2021, 36: 331-343. PMID: 33469930, DOI: 10.1002/ncp.10622.Peer-Reviewed Original ResearchConceptsNephrotic syndromeSteroid-refractory diseaseLong-term complicationsSteroid-sparing therapiesMetabolic bone diseaseCommon kidney diseaseSodium restrictionFrequent relapsesMost patientsCalcineurin inhibitorsDietary modificationKidney diseaseGlomerular filtrationNutrition interventionsBone diseaseAppropriate managementNutrition cliniciansNutrition managementDiseaseMicronutrient deficienciesEdemaPatientsSyndromeSerious casesTherapy
2014
Early Trends in Cystatin C and Outcomes in Patients with Cirrhosis and Acute Kidney Injury
Belcher JM, Sanyal AJ, Garcia-Tsao G, Ansari N, Coca SG, Shlipak MG, Parikh CR. Early Trends in Cystatin C and Outcomes in Patients with Cirrhosis and Acute Kidney Injury. International Journal Of Nephrology 2014, 2014: 708585. PMID: 24757564, PMCID: PMC3976933, DOI: 10.1155/2014/708585.Peer-Reviewed Original ResearchAcute kidney injuryKidney injuryGlomerular filtrationCystatin CCourse of AKIOnset of AKIProgression of AKIProspective multicenter studyEventual dialysisRenal dysfunctionSerum creatinineSevere complicationsComposite endpointPrimary outcomeMulticenter studyAdverse outcomesMore rapid identificationCystatin levelsWeight cysteine proteinase inhibitorCirrhosisCreatininePatientsMultivariate analysisAccurate markerReference group
2008
Disruption of Myosin 1e Promotes Podocyte Injury
Krendel M, Kim SV, Willinger T, Wang T, Kashgarian M, Flavell RA, Mooseker MS. Disruption of Myosin 1e Promotes Podocyte Injury. Journal Of The American Society Of Nephrology 2008, 20: 86-94. PMID: 19005011, PMCID: PMC2615733, DOI: 10.1681/asn.2007111172.Peer-Reviewed Original ResearchConceptsChronic renal injuryNormal glomerular filtrationGlomerular basement membraneRenal injuryKidney inflammationPodocyte foot processesGlomerular diseasePodocyte injuryGlomerular filtrationRenal tissueFoot processesPodocyte functionBasement membraneInjuryUltrastructural levelDiseaseMiceType IProteinuriaInflammationKidneyImportant rolePodocytesβ1 integrin expression by podocytes is required to maintain glomerular structural integrity
Pozzi A, Jarad G, Moeckel GW, Coffa S, Zhang X, Gewin L, Eremina V, Hudson BG, Borza DB, Harris RC, Holzman LB, Phillips CL, Fassler R, Quaggin SE, Miner JH, Zent R. β1 integrin expression by podocytes is required to maintain glomerular structural integrity. Developmental Biology 2008, 316: 288-301. PMID: 18328474, PMCID: PMC2396524, DOI: 10.1016/j.ydbio.2008.01.022.Peer-Reviewed Original ResearchConceptsEnd-stage renal failureStage renal failureGlomerular structural integrityWeeks of agePodocin-cre miceGlomerular basement membraneGlomerular filtration barrier integrityNormal glomerular basement membraneExpression of beta1Renal failureGlomerular pathologyFiltration barrier integrityProgressive podocyte lossPodocyte lossGlomerular filtrationΒ1 integrin expressionBarrier integrityPodocyte abnormalitiesHeteromeric receptorsCapillary loopsGlomerular capillary formationMiceIntegrin expressionExtracellular matrixPodocytes
2007
Advances in renal (patho)physiology using multiphoton microscopy
Sipos A, Toma I, Kang J, Rosivall L, Peti-Peterdi J. Advances in renal (patho)physiology using multiphoton microscopy. Kidney International 2007, 72: 1188-1191. PMID: 17667980, PMCID: PMC2424113, DOI: 10.1038/sj.ki.5002461.Peer-Reviewed Original ResearchConceptsKidney functionJuxtaglomerular apparatusTubuloglomerular feedbackIntrarenal renin-angiotensin systemRenin release mechanismRenin-angiotensin systemMultiphoton microscopyGlomerular filtrationInvasive approachClinical nephrologyVivo experimental approachesOrgan functionDeep optical sectioningTherapeutic toolCytosolic calciumDifferent organsImagingMultiphoton imagingQuantitative imagingExcitation fluorescence microscopyReal-time imagingKidneyNephrologyCell communicationDisease
2000
Endocrine Control of Acid‐Base Balance
Alpern R. Endocrine Control of Acid‐Base Balance. 2000, 570-603. DOI: 10.1002/cphy.cp070315.Peer-Reviewed Original ResearchAtrial natriuretic factorRenal acid excretionRenal acid-base regulationAcid-base balanceUrinary bufferParathyroid hormoneAngiotensin IINatriuretic factorGlomerular filtrationAcid excretionThyroid hormonesSteroid hormonesEndocrine controlHormonePeptide hormonesCatecholaminesSignaling intermediatesAdrenergic catecholaminesAcid-base regulationEndothelinMineralocorticoidsGlucocorticoidsExcretionInsulin
1969
Mechanism of change in the excretion of sodium per nephron when renal mass is reduced
Hayslett J, Kashgarian M, Epstein F. Mechanism of change in the excretion of sodium per nephron when renal mass is reduced. Journal Of Clinical Investigation 1969, 48: 1002-1006. PMID: 5771184, PMCID: PMC322314, DOI: 10.1172/jci106056.Peer-Reviewed Original ResearchConceptsSodium excretionRenal tissueProximal tubular absorptionExcretion of sodiumHealthy nephronsPopulation of nephronsRenal insufficiencyRenal ablationRenal failureTubular absorptionRenal massesSodium balanceGlomerular filtrationDistal tubulesExcretionNephronOsmotic loadEarly adjustmentStepwise increaseMechanisms of changeTissueUninephrectomyHyperfiltrationInsufficiencyRats
1967
Changes in Proximal and Distal Tubular Reabsorption Produced by Rapid Expansion of Extracellular Fluid*
Hayslett J, Kashgarian M, Epstein F. Changes in Proximal and Distal Tubular Reabsorption Produced by Rapid Expansion of Extracellular Fluid*. Journal Of Clinical Investigation 1967, 46: 1254-1263. PMID: 6027087, PMCID: PMC297124, DOI: 10.1172/jci105618.Peer-Reviewed Original ResearchConceptsTubular reabsorptionTubular diameterDistal tubular reabsorptionGlomerular filtration rateProximal tubular reabsorptionAdministration of aldosteroneLoop of HenleAcute infusionFiltration rateRenal contentSaline infusionGlomerular filtrationSegments of tubulesIsotonic salineProximal tubulesExcretion of saltTubular flowReabsorptionExtracellular fluidInfusionTubulesInterstitial volumeRatsTransit timeAldosterone
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