2017
Hypothesis of K+-Recycling Defect Is Not a Primary Deafness Mechanism for Cx26 (GJB2) Deficiency
Zhao H. Hypothesis of K+-Recycling Defect Is Not a Primary Deafness Mechanism for Cx26 (GJB2) Deficiency. Frontiers In Molecular Neuroscience 2017, 10: 162. PMID: 28603488, PMCID: PMC5445178, DOI: 10.3389/fnmol.2017.00162.Peer-Reviewed Original ResearchHearing lossDeafness mechanismCx26 deficiencyInner ear gap junctionsHair cell degenerationNonsyndromic hearing lossDisruption of permeabilityCongenital deafnessCell degenerationHair cellsHair cell excitationHereditary deafnessCell excitationConnexin26 MutationsGap junctional channelsGap junctionsDevelopmental disordersDeficiencyDeafnessExtracellular spaceReview articleJunctional channelsDegeneration
2008
Gap junctions in Malpighian tubules of Aedes aegypti
Weng XH, Piermarini PM, Yamahiro A, Yu MJ, Aneshansley DJ, Beyenbach KW. Gap junctions in Malpighian tubules of Aedes aegypti. Journal Of Experimental Biology 2008, 211: 409-422. PMID: 18203997, DOI: 10.1242/jeb.011213.Peer-Reviewed Original ResearchConceptsMalpighian tubulesGap junctionsMolecular evidenceGap junctional channelsInnexin 1Principal cellsVertebrate tissuesLeucokinin-VIIIEpithelial cellsLucifer YellowAedes aegyptiGap junction resistanceRT-PCRCellsElectrical couplingGap junction conductanceRinger bathPhysiological demonstrationInnexinsIsolated Malpighian tubulesTubule lumenCalcium ionophoreDouble cable modelMetabolic inhibitionTransepithelial voltage
2005
Gap junctional hemichannel-mediated ATP release and hearing controls in the inner ear
Zhao H, Yu N, Fleming C. Gap junctional hemichannel-mediated ATP release and hearing controls in the inner ear. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 18724-18729. PMID: 16344488, PMCID: PMC1317927, DOI: 10.1073/pnas.0506481102.Peer-Reviewed Original ResearchConceptsHemichannel-mediated ATP releaseHair cellsGap junctional blockerActive cochlear amplifierAuditory sensory hair cellsSensory hair cellsEffect of ATPP2 receptorsExtracellular Ca2OHC electromotilityCochlear sensitivityATP releaseConnexin gap junctionsExtracellular ATPConnexin expressionInner earImmunofluorescent stainingHearing controlsHearing sensitivityOuter hair cell electromotilityCochleaHair cell electromotilityConnexin hemichannelsCochlear fluidsGap junctional channels
2001
Gap Junctional Channels Regulate Acid Secretion in the Mammalian Gastric Gland
Radebold K, Horakova E, Gloeckner J, Ortega G, Spray D, Vieweger H, Siebert K, Manuelidis L, Geibel J. Gap Junctional Channels Regulate Acid Secretion in the Mammalian Gastric Gland. The Journal Of Membrane Biology 2001, 183: 147-153. PMID: 11696856, DOI: 10.1007/s00232-001-0062-9.Peer-Reviewed Original ResearchConceptsGap junction channelsAdjacent parietal cellsCell communicationJunction channelsFunctional gap junction channelsGap junctional channelsPotential physiological roleLucifer yellow transferGap junctional proteinGastric glandsParietal cellsWestern blot analysisJunctional channelsJunctional proteinsPhysiological roleRapid cellBlot analysisCalcium signalsBasolateral membraneCell microinjectionAcid secretory processTransfer of dyeSecretory processIntact glandsCalcium wave propagation
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