Genetic Variation in Base Excision Repair Pathway Genes, Pesticide Exposure, and Prostate Cancer Risk
Barry KH, Koutros S, Berndt SI, Andreotti G, Hoppin JA, Sandler DP, Burdette LA, Yeager M, Freeman LE, Lubin JH, Ma X, Zheng T, Alavanja MC. Genetic Variation in Base Excision Repair Pathway Genes, Pesticide Exposure, and Prostate Cancer Risk. Environmental Health Perspectives 2011, 119: 1726-1732. PMID: 21810555, PMCID: PMC3261977, DOI: 10.1289/ehp.1103454.Peer-Reviewed Original ResearchConceptsProstate cancer riskCancer riskSingle nucleotide polymorphismsPesticide applicatorsCT/TT genotypesPesticide manufacturing workersCase-control studyProstate cancer casesLogistic regression modelsTag single nucleotide polymorphismsBase excision repair pathway genesProstate cancerCancer casesFamily historyOxidative DNA damageTT genotypeCC genotypeMale controlsExposure variablesPesticide exposureBase excision repairManufacturing workersUnderlying mechanismRiskBER genesPolymorphism in the DNA repair enzyme XRCC1: Utility of current database and implications for human health risk assessment
Ginsberg G, Angle K, Guyton K, Sonawane B. Polymorphism in the DNA repair enzyme XRCC1: Utility of current database and implications for human health risk assessment. Mutation Research/Fundamental And Molecular Mechanisms Of Mutagenesis 2011, 727: 1-15. PMID: 21352951, DOI: 10.1016/j.mrrev.2011.02.001.Peer-Reviewed Original ResearchConceptsBase excision repairDNA repairGene expressionRepair functionUpstream regulatory sequencesDNA damaging agentsHomozygous variantToxicodynamic responseXRCC1 levelsRegulatory sequencesBinding sequenceExcision repairDamaging agentsProtein structureBER genesDNA damageAllele frequenciesCurrent databasePolymorphismGenotype effectsArg399Gln variantPhenotypeGenetic polymorphismsXRCC1Environmental agents
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