2025
ETS emerges to heat up adipose
Rodeheffer M. ETS emerges to heat up adipose. Genes & Development 2025 PMID: 40389324, DOI: 10.1101/gad.352966.125.Peer-Reviewed Original ResearchTranscription factor bindingE26 transformation-specific (ETS) transcription factorsPromoter chromatin accessibilityChromatin accessibilityFactor bindingTranscription factorsHistone acetylationAdipose biologyGene expressionETV4HistoneTranscriptionGenesUCP1AcetylationE26AdipogenesisBindingBiologyThermogenesisExpressionAdipose
2021
IL-27 signalling promotes adipocyte thermogenesis and energy expenditure
Wang Q, Li D, Cao G, Shi Q, Zhu J, Zhang M, Cheng H, Wen Q, Xu H, Zhu L, Zhang H, Perry RJ, Spadaro O, Yang Y, He S, Chen Y, Wang B, Li G, Liu Z, Yang C, Wu X, Zhou L, Zhou Q, Ju Z, Lu H, Xin Y, Yang X, Wang C, Liu Y, Shulman GI, Dixit VD, Lu L, Yang H, Flavell RA, Yin Z. IL-27 signalling promotes adipocyte thermogenesis and energy expenditure. Nature 2021, 600: 314-318. PMID: 34819664, DOI: 10.1038/s41586-021-04127-5.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAnimalsBariatric SurgeryDisease Models, AnimalEnergy MetabolismFemaleHumansInsulin ResistanceInterleukin-27MaleMiceObesityp38 Mitogen-Activated Protein KinasesPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaReceptors, InterleukinSignal TransductionThermogenesisUncoupling Protein 1ConceptsIL-27Beige adipose tissueAdipose tissueSerum IL-27Diet-induced obesityBariatric surgeryMetabolic morbidityImmunological factorsInsulin resistanceObesity showTherapeutic administrationMetabolic disordersMouse modelObesityPromising targetEnergy expenditureSignaling promotesThermogenesisBody temperatureMetabolic programsImportant roleTissueCritical roleImmunotherapyMorbiditymicroRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity
Horie T, Nakao T, Miyasaka Y, Nishino T, Matsumura S, Nakazeki F, Ide Y, Kimura M, Tsuji S, Rodriguez RR, Watanabe T, Yamasaki T, Xu S, Otani C, Miyagawa S, Matsushita K, Sowa N, Omori A, Tanaka J, Nishimura C, Nishiga M, Kuwabara Y, Baba O, Watanabe S, Nishi H, Nakashima Y, Picciotto MR, Inoue H, Watanabe D, Nakamura K, Sasaki T, Kimura T, Ono K. microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity. Nature Communications 2021, 12: 843. PMID: 33594062, PMCID: PMC7886914, DOI: 10.1038/s41467-021-21107-5.Peer-Reviewed Original ResearchConceptsSympathetic nerve activityAdaptive thermogenesisNerve activityCre miceMiR-33Brown adipose tissue thermogenesisDBH-positive neuronsMiR-33 levelsGABAergic inhibitory neurotransmissionSympathetic nerve toneCentral neural circuitsAdipose tissue thermogenesisGamma-aminobutyric acidDBH-positive cellsMiR-33 deficiencyWhole-body metabolismCold-induced thermogenesisInhibitory neurotransmissionBAT thermogenesisTissue thermogenesisReceptor subunit genesNeural circuitsAdaptive defense mechanismsThermogenesisMiceAn update on brown adipose tissue biology: a discussion of recent findings
Gaspar RC, Pauli JR, Shulman GI, Muñoz VR. An update on brown adipose tissue biology: a discussion of recent findings. AJP Endocrinology And Metabolism 2021, 320: e488-e495. PMID: 33459179, PMCID: PMC7988785, DOI: 10.1152/ajpendo.00310.2020.Peer-Reviewed Original ResearchConceptsBrown adipose tissueBAT thermogenesisBrown adipose tissue biologyEnergy expenditureBrown-like cellsWhole-body glucoseAdipose tissue biologyBAT metabolismAdrenergic drugsAdipose tissuePotential treatmentThermogenic activityWhite adipocytesBody glucoseFat metabolismEndocrine mechanismsBeneficial roleSecretory moleculesActivity capacityTissue biologyThermogenesisRecent findingsRecent studiesAdditional focusMetabolism
2018
Acute physical exercise increases leptin‐induced hypothalamic extracellular signal‐regulated kinase1/2 phosphorylation and thermogenesis of obese mice
Gaspar R, Muñoz V, Kuga G, Nakandakari S, Minuzzi L, Botezelli J, da Silva A, Cintra D, de Moura L, Ropelle E, Pauli J. Acute physical exercise increases leptin‐induced hypothalamic extracellular signal‐regulated kinase1/2 phosphorylation and thermogenesis of obese mice. Journal Of Cellular Biochemistry 2018, 120: 697-704. PMID: 30206970, DOI: 10.1002/jcb.27426.Peer-Reviewed Original ResearchConceptsAcute physical exerciseBrown adipose tissueObese micePhysical exerciseEnergy expenditureERK1/2 phosphorylationTreatment of obesityExtracellular signal-regulated kinase1/2 (ERK1/2) phosphorylationProtein 1 (UCP1) contentExtracellular signal-regulated kinase 1/2Signal-regulated kinase 1/2Sympathetic signalsSpontaneous activityAdipose tissueP-ERK1/2Main interventionThermoregulatory effectsMiceKey mediatorThermogenesisOxygen uptakeMolecular changesKinase 1/2ObeseObesity
2015
Distribution of temperature changes and neurovascular coupling in rat brain following 3,4‐methylenedioxymethamphetamine (MDMA, “ecstasy”) exposure
Coman D, Sanganahalli BG, Jiang L, Hyder F, Behar KL. Distribution of temperature changes and neurovascular coupling in rat brain following 3,4‐methylenedioxymethamphetamine (MDMA, “ecstasy”) exposure. NMR In Biomedicine 2015, 28: 1257-1266. PMID: 26286889, PMCID: PMC4573923, DOI: 10.1002/nbm.3375.Peer-Reviewed Original ResearchConceptsNeurovascular couplingBlood flowNeuronal activityNeural activityWhole-body hyperthermiaAbused psychostimulantMethylenedioxymethamphetamine (MDMA) exposureNeurovascular responseCortex temperatureMDMA effectsRat cortexRat brainBrain temperatureSubcortical regionsBrain regionsCortexSubcortexMDMA actionSkeletal muscleMonoaminergic stimulationBrainMDMACBFBody temperatureThermogenesis
1995
Serotonin and Thermoregulation
Schwartz P, Wehr T, Rosenthal N, Bartko J, Oren D, Luetke C, Murphy D. Serotonin and Thermoregulation. Neuropsychopharmacology 1995, 13: 105-115. PMID: 8597522, DOI: 10.1016/0893-133x(95)00026-a.Peer-Reviewed Original ResearchConceptsSignificant biphasic changesPlasma norepinephrine concentrationCentral serotonergic functionReceptor-mediated mechanismMammalian energy balanceInitial hypothermiaNorepinephrine concentrationsMetabolic thermogenesisSerotonergic functionSkin temperature recordingsEffector mechanismsPlasma concentrationsHealthy volunteersBiphasic changeNonhuman primatesCore hyperthermiaRectal temperatureProgressive hyperthermiaRecording sitesSignificant increaseCPPHyperthermiaThermogenesisPlaceboChlorophenylpiperazine
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply