2016
Effects of aerobic exercise intensity on ambulatory blood pressure and vascular responses in resistant hypertension
Santos LP, Moraes RS, Vieira PJ, Ash GI, Waclawovsky G, Pescatello LS, Umpierre D. Effects of aerobic exercise intensity on ambulatory blood pressure and vascular responses in resistant hypertension. Journal Of Hypertension 2016, 34: 1317-1324. PMID: 27137175, DOI: 10.1097/hjh.0000000000000961.Peer-Reviewed Original ResearchConceptsForearm blood flowResistant hypertensionDiastolic pressureAmbulatory BPBlood flowExercise intensityPoor blood pressure controlAmbulatory systolic pressureDevice-based proceduresAcute hemodynamic effectsBlood pressure controlAmbulatory blood pressureVenous occlusion plethysmographyMaximal exercise testingModerate aerobic exerciseModerate intensityAerobic exercise intensityVascular resistanceExercise testingHemodynamic effectsOcclusion plethysmographyBlood pressureResistant patientsSystolic pressureReactive hyperemia
2012
Polymorphisms in the transcription factor NRF2 and forearm vasodilator responses in humans
Marczak ED, Marzec J, Zeldin DC, Kleeberger SR, Brown NJ, Pretorius M, Lee CR. Polymorphisms in the transcription factor NRF2 and forearm vasodilator responses in humans. Pharmacogenetics And Genomics 2012, 22: 620-628. PMID: 22668754, PMCID: PMC3599320, DOI: 10.1097/fpc.0b013e32835516e5.Peer-Reviewed Original ResearchConceptsForearm vascular resistanceForearm blood flowVariant allele carriersVasodilator responseSodium nitroprussideVascular functionAllele carriersStrain-gauge venous occlusion plethysmographyLower forearm blood flowEndothelial-independent mannerForearm vasodilator responseVenous occlusion plethysmographyWild-type individualsTranscription factor Nrf2Endothelial dysfunctionOcclusion plethysmographyVascular resistanceIncremental dosesCardiovascular diseaseBlood flowG genotypeA polymorphismSignificant associationBasal conditionsFactor Nrf2
2010
Genetic Variation in Soluble Epoxide Hydrolase (EPHX2) Is Associated With Forearm Vasodilator Responses in Humans
Lee CR, Pretorius M, Schuck RN, Burch LH, Bartlett J, Williams SM, Zeldin DC, Brown NJ. Genetic Variation in Soluble Epoxide Hydrolase (EPHX2) Is Associated With Forearm Vasodilator Responses in Humans. Hypertension 2010, 57: 116-122. PMID: 21098312, PMCID: PMC3020911, DOI: 10.1161/hypertensionaha.110.161695.Peer-Reviewed Original ResearchConceptsForearm blood flowVariant allele carriersForearm vasodilator responseForearm vascular resistanceSoluble epoxide hydrolaseVascular resistanceVasodilator responseBlood flowAllele carriersSodium nitroprussideVascular functionStrain-gauge venous occlusion plethysmographyHighest forearm blood flowLower forearm vascular resistanceSignificant associationCytochrome P450-derived epoxyeicosatrienoic acidsEpoxide hydrolaseVenous occlusion plethysmographyCardiovascular disease riskEndothelium-independent mannerWild-type individualsOcclusion plethysmographyPotent vasodilatorEpoxyeicosatrienoic acidsPreclinical models
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