2025
METTL3 modulates colonic epithelium integrity via maintaining the self-renewal and differentiation of Lgr5+ stem cell
Ding C, Yang X, Liu H, Roulis M, Chen H, Chen Y, Xu H, Gao Y, Zhong J, Li H, Ye Y, Cai W, Hu W, Wang Z. METTL3 modulates colonic epithelium integrity via maintaining the self-renewal and differentiation of Lgr5+ stem cell. Journal Of Molecular Cell Biology 2025, 17: mjae060. PMID: 39762134, PMCID: PMC12309382, DOI: 10.1093/jmcb/mjae060.Peer-Reviewed Original ResearchSelf-RenewalStem cellsMaturation of goblet cellsDifferentiation of Lgr5Ulcerative colitisHomeostasis of intestinal epitheliumColonic stem cellsGoblet cellsSpontaneous inflammationIntestinal dysplasiaColonic mucosaUC treatmentLgr5Epithelium integrityDepletion of METTL3Intestinal epitheliumTherapeutic targetInflammationDifferentiation capacityMETTL3 expressionUC samplesMETTL3 levelsExpression levelsM6A methylationCells
2015
The Endometrium as a Source of Mesenchymal Stem Cells for Regenerative Medicine1
Mutlu L, Hufnagel D, Taylor HS. The Endometrium as a Source of Mesenchymal Stem Cells for Regenerative Medicine1. Biology Of Reproduction 2015, 92: 138, 1-11. PMID: 25904012, PMCID: PMC4652610, DOI: 10.1095/biolreprod.114.126771.Peer-Reviewed Original ResearchConceptsMesenchymal stem cellsStem cellsEmbryonic stem cellsAdult stem cellsPluripotent stem cellsPossibility of regeneratingRegenerative medicineTissue regenerationMature cell typesEndometrial stem cellsCell therapyDifferentiation capacityHematopoietic stem cellsCell typesNew frontierNovel sourceCurrent understandingCellsTherapeutic potential
2014
Modulation of oligodendrocyte generation during a critical temporal window after NG2 cell division
Hill RA, Patel KD, Goncalves CM, Grutzendler J, Nishiyama A. Modulation of oligodendrocyte generation during a critical temporal window after NG2 cell division. Nature Neuroscience 2014, 17: 1518-1527. PMID: 25262495, PMCID: PMC4275302, DOI: 10.1038/nn.3815.Peer-Reviewed Original ResearchEstablishment of Human cell Type-Specific iPS cells with Enhanced Chondrogenic Potential
Guzzo RM, Scanlon V, Sanjay A, Xu RH, Drissi H. Establishment of Human cell Type-Specific iPS cells with Enhanced Chondrogenic Potential. Stem Cell Reviews And Reports 2014, 10: 820-829. PMID: 24958240, DOI: 10.1007/s12015-014-9538-8.Peer-Reviewed Original ResearchConceptsIPS cellsCell typesVivo functional analysisSpecialized cell typesNew cellular toolsSomatic cell typesChondrogenic potentialDelivery of Oct4Pluripotent differentiation capacityCell linesPluripotent stem cellsArticular chondrocytesHuman articular chondrocytesFate potentialEnhanced chondrogenic potentialHigh chondrogenic potentialSpecific lineagesFibroblast cell lineTissue of originCellular toolsGene expressionFunctional analysisDermal fibroblast cell lineChondrogenic differentiationDifferentiation capacity
2007
Stem Cell Transplantation: The Lung Barrier
Schrepfer S, Deuse T, Reichenspurner H, Fischbein M, Robbins R, Pelletier M. Stem Cell Transplantation: The Lung Barrier. Transplantation Proceedings 2007, 39: 573-576. PMID: 17362785, DOI: 10.1016/j.transproceed.2006.12.019.Peer-Reviewed Original ResearchConceptsMesenchymal stem cellsSodium nitroprussideMesenchymal stem cell passagingIV injectionMesenchymal stem cell injectionIntravenous (IVAssessed in vitroFluorescence-labeled microspheresMesenchymal stem cell migrationPulmonary microvasculatureTransplantation strategiesSN injectionInjured organsLung sectionsMouse mesenchymal stem cellsMSCs in vitroMesenchymal lineagesStem cellsLungLung capillariesCell trappingDifferentiation capacityPulmonary capillariesCellsInjection
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