2020
Staphylococcus aureus α-toxin suppresses antigen-specific T cell responses
Lee B, Olaniyi R, Kwiecinski JM, Wardenburg JB. Staphylococcus aureus α-toxin suppresses antigen-specific T cell responses. Journal Of Clinical Investigation 2020, 130: 1122-1127. PMID: 31873074, PMCID: PMC7269593, DOI: 10.1172/jci130728.Peer-Reviewed Original ResearchConceptsT cell responsesSkin infectionsCell responsesAntigen-specific T cell responsesOVA-specific T cell responsesT cell-mediated immunityS. aureusΑ-toxinAntigen-specific modelChicken egg OVACell-mediated immunityT cell memoryAntigen-specific memoryPrimary skin infectionsInvasive staphylococcal diseaseStaphylococcus aureus α-toxinDevelopment of immunityΑ-toxin expressionAureus α-toxinProtective immunityInvasive infectionsLeading causeLoss of DCsStaphylococcal diseaseLong-term protection
2015
Superantigens produced by catheter-associated Staphylococcus aureus elicit systemic inflammatory disease in the absence of bacteremia
Chung J, Greenwood-Quaintance K, Karau MJ, Tilahun A, Khaleghi SR, Chowdhary VR, David CS, Patel R, Rajagopalan G. Superantigens produced by catheter-associated Staphylococcus aureus elicit systemic inflammatory disease in the absence of bacteremia. Journal Of Leukocyte Biology 2015, 98: 271-281. PMID: 25979434, PMCID: PMC4501677, DOI: 10.1189/jlb.4a1214-577rr.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCatheter-Related InfectionsCatheters, IndwellingCD4-Positive T-LymphocytesEnterotoxinsGene DeletionHistocompatibility AntigensHumansKidneyLiverLungLymphocyte ActivationMiceMice, TransgenicReceptors, Antigen, T-Cell, alpha-betaSpleenStaphylococcal InfectionsStaphylococcus aureusSuperantigensConceptsS. aureusHLA-DR3 transgenic miceLong intravenous catheterSystemic immune activationSerum cytokine levelsSystemic inflammatory diseaseAbsence of bacteremiaMHC class II moleculesInvasive staphylococcal diseaseToxigenic S. aureusClinical S. aureus isolatesS. aureus isolatesClass II moleculesIsogenic S. aureusCytokine levelsHLA-DR3Immune activationInflammatory diseasesIntravenous cathetersStaphylococcal diseaseRole of SAgsDevice-associated infectionsT cellsClinical consequencesForeign body
2012
Coagulases as Determinants of Protective Immune Responses against Staphylococcus aureus
McAdow M, DeDent AC, Emolo C, Cheng AG, Kreiswirth BN, Missiakas DM, Schneewind O. Coagulases as Determinants of Protective Immune Responses against Staphylococcus aureus. Infection And Immunity 2012, 80: 3389-3398. PMID: 22825443, PMCID: PMC3457572, DOI: 10.1128/iai.00562-12.Peer-Reviewed Original Research
2010
IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challenge
Kim HK, DeDent A, Cheng AG, McAdow M, Bagnoli F, Missiakas DM, Schneewind O. IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challenge. Vaccine 2010, 28: 6382-6392. PMID: 20226248, PMCID: PMC3095377, DOI: 10.1016/j.vaccine.2010.02.097.Peer-Reviewed Original ResearchConceptsIntravenous challengeAbscess formationStaphylococcus aureus abscess formationLethal intravenous challengePathogenesis of infectionHospital-acquired infectionsStaphylococcal abscess formationNaïve miceActive immunizationLethal challengeSurface proteinsOpsonophagocytic killingStaphylococcal diseaseFrequent causeSubunit vaccineExperimental animalsMouse bloodAntibodiesStaphylococcus aureusBind hemoglobinVaccineInfectionMiceStaphylococciBacteremia
2005
Increased Sensitivity to Staphylococcal Enterotoxin B following Adenoviral Infection
Yarovinsky TO, Mohning MP, Bradford MA, Monick MM, Hunninghake GW. Increased Sensitivity to Staphylococcal Enterotoxin B following Adenoviral Infection. Infection And Immunity 2005, 73: 3375-3384. PMID: 15908364, PMCID: PMC1111844, DOI: 10.1128/iai.73.6.3375-3384.2005.Peer-Reviewed Original ResearchConceptsStaphylococcal enterotoxin BAdenoviral infectionEnterotoxin BStaphylococcal enterotoxin B exposureD-galactosamine sensitizationSystemic adenoviral infectionIncreased sensitivityPrime miceMajor virulence factorLiver injuryProfound hypothermiaStaphylococcal diseaseMurine modelGamma interferonKnockout miceB exposureToxic shockInfectionStaphylococcal enterotoxinsMiceVirulence factorsIncreased productionExposureHypothermiaInjury
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