2025
Brief exposure to oral antibiotics has age-dependent effects on morphine reward and gene expression in the medial prefrontal cortex of adolescent and adult mice
Hofford R, Sens J, Shipman A, Kimble V, Coric C, Meckel K, Kiraly D. Brief exposure to oral antibiotics has age-dependent effects on morphine reward and gene expression in the medial prefrontal cortex of adolescent and adult mice. Brain Behavior And Immunity 2025, 129: 724-735. PMID: 40645237, DOI: 10.1016/j.bbi.2025.07.005.Peer-Reviewed Original ResearchMedial prefrontal cortexPrefrontal cortexMorphine rewardDrug reward behaviorsMorphine place preferenceSubstance use disordersResponse to morphineCortical gene expressionOral antibioticsDrug rewardPlace preferenceOpioid rewardAdolescent miceReward behaviorAge-dependent effectsBrain regionsAdult miceHeightened vulnerabilityEffects of oral antibioticsRewardOpioid sensitivityCortexDrug useRodent modelsAdolescents
2020
Convergent molecular, cellular, and cortical neuroimaging signatures of major depressive disorder
Anderson KM, Collins MA, Kong R, Fang K, Li J, He T, Chekroud AM, Yeo BTT, Holmes AJ. Convergent molecular, cellular, and cortical neuroimaging signatures of major depressive disorder. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 25138-25149. PMID: 32958675, PMCID: PMC7547155, DOI: 10.1073/pnas.2008004117.Peer-Reviewed Original ResearchMeSH KeywordsAstrocytesAutopsyBrainCerebral CortexDepressive Disorder, MajorFemaleGene Expression ProfilingGene Expression RegulationGene OntologyGene Regulatory NetworksGenome-Wide Association StudyGenomicsHumansInterneuronsMaleMultifactorial InheritanceNeuroimagingSignal TransductionSingle-Cell AnalysisSomatostatinConceptsGenome-wide association studiesTranscriptional dataTranscriptional correlatesMajor depressive disorderCorrelates of depressionGene transcriptionSpecific genesGene expressionGene dysregulationIntegrative analysisBiological pathwaysAssociation studiesExpression dataGenesMolecular pathwaysCortical gene expressionDepressive disorderEx vivo geneCells associatesIntegrated analysisVivo geneBiological systemsRegulationPathwayUK Biobank
2018
Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor
Preller KH, Burt JB, Ji JL, Schleifer CH, Adkinson BD, Stämpfli P, Seifritz E, Repovs G, Krystal JH, Murray JD, Vollenweider FX, Anticevic A. Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor. ELife 2018, 7: e35082. PMID: 30355445, PMCID: PMC6202055, DOI: 10.7554/elife.35082.Peer-Reviewed Original ResearchConceptsLysergic acid diethylamideLSD effectsResting-state functional connectivityCortical gene expressionHealthy human participantsThalamic connectivityDopamine receptorsReceptor contributionNeurobiological effectsAgonist activityFunctional connectivityBrain connectivityAcid diethylamideReceptorsKetanserinNeuropharmacologyLSD mechanismCritical roleGene expressionAltered statesHuman participantsRational developmentSerotonin
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