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Researchers Demonstrate XBP1 Reduces Severity of Polycystic Kidney Disease
Most families with autosomal dominant polycystic kidney disease (ADPKD) possess a genetic mutation in PKD1, that impacts the protein polycystin-1 (PC1). In a new article published online Friday, October 21, 2022, in the Journal of the American Society of Nephrology, a Yale team led by Stefan Somlo, MD and Sorin Fedeles, PhD, MBA demonstrated that the activation of the transcription factor XBP1 in vivo can improve the residual function of a mutant form of PC1, thereby decreasing the severity of ADPKD.