Yannick Jacob, PhD
Associate Professor Tenure of Molecular, Cellular and Developmental Biology
Research & Publications
Biography
Locations
Coauthors
Selected Publications
- H3.1K27me1 loss confers Arabidopsis resistance to Geminivirus by sequestering DNA repair proteins onto host genomeWang Z, Castillo-González C, Zhao C, Tong C, Li C, Zhong S, Liu Z, Xie K, Zhu J, Wu Z, Peng X, Jacob Y, Michaels S, Jacobsen S, Zhang X. H3.1K27me1 loss confers Arabidopsis resistance to Geminivirus by sequestering DNA repair proteins onto host genome. Nature Communications 2023, 14: 7484. PMID: 37980416, PMCID: PMC10657422, DOI: 10.1038/s41467-023-43311-1.
- The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replicationDavarinejad H, Huang YC, Mermaz B, LeBlanc C, Poulet A, Thomson G, Joly V, Muñoz M, Arvanitis-Vigneault A, Valsakumar D, Villarino G, Ross A, Rotstein BH, Alarcon EI, Brunzelle JS, Voigt P, Dong J, Couture JF, Jacob Y. The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication. Science 2022, 375: 1281-1286. PMID: 35298257, PMCID: PMC9153895, DOI: 10.1126/science.abm5320.
- H3.1K27me1 maintains transcriptional silencing and genome stability by preventing GCN5-mediated histone acetylationDong J, LeBlanc C, Poulet A, Mermaz B, Villarino G, Webb KM, Joly V, Mendez J, Voigt P, Jacob Y. H3.1K27me1 maintains transcriptional silencing and genome stability by preventing GCN5-mediated histone acetylation. The Plant Cell 2021, 33: 961-979. PMID: 33793815, PMCID: PMC8226292, DOI: 10.1093/plcell/koaa027.
- Increased efficiency of targeted mutagenesis by CRISPR/Cas9 in plants using heat stressLeBlanc C, Zhang F, Mendez J, Lozano Y, Chatpar K, Irish V, Jacob Y. Increased efficiency of targeted mutagenesis by CRISPR/Cas9 in plants using heat stress. The Plant Journal 2017, 93: 377-386. PMID: 29161464, DOI: 10.1111/tpj.13782.
- Selective Methylation of Histone H3 Variant H3.1 Regulates Heterochromatin ReplicationJacob Y, Bergamin E, Donoghue MT, Mongeon V, LeBlanc C, Voigt P, Underwood CJ, Brunzelle JS, Michaels SD, Reinberg D, Couture JF, Martienssen RA. Selective Methylation of Histone H3 Variant H3.1 Regulates Heterochromatin Replication. Science 2014, 343: 1249-1253. PMID: 24626927, PMCID: PMC4049228, DOI: 10.1126/science.1248357.
- Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferasesJacob Y, Stroud H, LeBlanc C, Feng S, Zhuo L, Caro E, Hassel C, Gutierrez C, Michaels SD, Jacobsen SE. Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases. Nature 2010, 466: 987-991. PMID: 20631708, PMCID: PMC2964344, DOI: 10.1038/nature09290.
- ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencingJacob Y, Feng S, LeBlanc CA, Bernatavichute YV, Stroud H, Cokus S, Johnson LM, Pellegrini M, Jacobsen SE, Michaels SD. ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing. Nature Structural & Molecular Biology 2009, 16: 763-768. PMID: 19503079, PMCID: PMC2754316, DOI: 10.1038/nsmb.1611.