2020
Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates
Micali N, Kim SK, Diaz-Bustamante M, Stein-O’Brien G, Seo S, Shin JH, Rash BG, Ma S, Wang Y, Olivares NA, Arellano JI, Maynard KR, Fertig EJ, Cross AJ, Bürli RW, Brandon NJ, Weinberger DR, Chenoweth JG, Hoeppner DJ, Sestan N, Rakic P, Colantuoni C, McKay RD. Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates. Cell Reports 2020, 31: 107599. PMID: 32375049, PMCID: PMC7357345, DOI: 10.1016/j.celrep.2020.107599.Peer-Reviewed Original ResearchConceptsNeural stem cellsNeuronal fateProliferative neural stem cellsStem cellsPluripotent linesTelencephalic fateRNA sequencingLineage tracingHuman neural stem cellsGlutamatergic excitatory neuronsMonkey brain sectionsNeuronal trajectoriesCell imagingCortical excitatoryCerebral cortexFateExcitatory neuronsBrain sectionsHuman telencephalonNeuropsychiatric disordersAcute transitionPluripotencyCellsCortexSequencing
2009
Differentiation of Neural Progenitor Cells in a Microfluidic Chip‐Generated Cytokine Gradient
Park J, Kim S, Woo D, Lee E, Kim J, Lee S. Differentiation of Neural Progenitor Cells in a Microfluidic Chip‐Generated Cytokine Gradient. Stem Cells 2009, 27: 2646-2654. PMID: 19711444, DOI: 10.1002/stem.202.Peer-Reviewed Original ResearchConceptsCell typesNeural progenitorsHuman embryonic stem cellsEarly embryonic developmentStem cellsEmbryonic stem cellsCytokine gradientsEnriched populationNeural progenitor cellsPrimitive stem cellsEmbryonic developmentSignaling moleculesDiverse tissuesCell body clustersProgenitor cellsNeurite bundlesGrowth factorProgenitorsCell-friendly microenvironmentCellsDifferentiationExogenous cytokinesImportant roleBody clustersSpatial gradients
2006
Neurogenic effect of vascular endothelial growth factor during germ layer formation of human embryonic stem cells
Kim B, Kim S, Shim J, Woo D, Gil J, Kim S, Kim J. Neurogenic effect of vascular endothelial growth factor during germ layer formation of human embryonic stem cells. FEBS Letters 2006, 580: 5869-5874. PMID: 17027979, DOI: 10.1016/j.febslet.2006.09.053.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cellsVascular endothelial growth factorGerm layer formationEmbryonic stem cellsEmbryoid bodiesEndothelial growth factorNeurogenic effectsGrowth factorStem cellsEffects of VEGFNeuroectodermal genesVascular endothelial cellsHESC differentiationNeural rosettesDopaminergic neuronsGene expressionNeural progenitorsTerminal differentiationVEGF treatmentPotent mitogenEndothelial cellsNeuroectodermal differentiationDifferentiationCellsExpression