2018
Nanotopographical regulation of pancreatic islet-like cluster formation from human pluripotent stem cells using a gradient-pattern chip
Kim J, Park B, Kim S, Lee D, Lee G, Kim D, Choi B, Lee K, Kim J. Nanotopographical regulation of pancreatic islet-like cluster formation from human pluripotent stem cells using a gradient-pattern chip. Acta Biomaterialia 2018, 95: 337-347. PMID: 30529081, DOI: 10.1016/j.actbio.2018.12.011.Peer-Reviewed Original ResearchConceptsHuman pluripotent stem cellsPancreatic islet-like clustersStem cell fatePluripotent stem cellsIslet-like clustersCell fateSpecific functional cell typesCell typesPancreatic endocrine progenitorsStem cellsStem cell nichePancreatic islet developmentFunctional cell typesSpecific cell typesPancreatic cellsDevelopmental regulatorsEndocrine progenitorsCell nicheMechanical cuesPancreatic β-cellsPolyhormonal cells
2012
Sox2 Acts through Sox21 to Regulate Transcription in Pluripotent and Differentiated Cells
Kuzmichev A, Kim S, D’Alessio A, Chenoweth J, Wittko I, Campanati L, McKay R. Sox2 Acts through Sox21 to Regulate Transcription in Pluripotent and Differentiated Cells. Current Biology 2012, 22: 1705-1710. PMID: 22902753, DOI: 10.1016/j.cub.2012.07.013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCDX2 Transcription FactorCell DifferentiationCell LineColonic NeoplasmsFibroblastsGene Expression RegulationHomeodomain ProteinsIntestinal MucosaIntestinesMiceMice, TransgenicOctamer Transcription Factor-3Pluripotent Stem CellsSOXB1 Transcription FactorsSOXB2 Transcription FactorsTranscription FactorsTranscription, GeneticTranscriptional ActivationConceptsStem cellsImportant transcriptional regulatorStem cell renewalIntestinal stem cellsAdult stem cellsColon cancer cellsEndodermal identityPluripotent stem cellsEffect of SOX2Gene familyCell identityPluripotent stateTranscriptional partnersTranscriptional regulatorsTranscriptional inductionTranscription factorsMaster regulatorTranscriptional actionGene expressionSox21Differentiated cellsCell renewalSOX2General mediatorCell types
2009
Differentiation of Neural Progenitor Cells in a Microfluidic Chip‐Generated Cytokine Gradient
Park J, Kim S, Woo D, Lee E, Kim J, Lee S. Differentiation of Neural Progenitor Cells in a Microfluidic Chip‐Generated Cytokine Gradient. Stem Cells 2009, 27: 2646-2654. PMID: 19711444, DOI: 10.1002/stem.202.Peer-Reviewed Original ResearchConceptsCell typesNeural progenitorsHuman embryonic stem cellsEarly embryonic developmentStem cellsEmbryonic stem cellsCytokine gradientsEnriched populationNeural progenitor cellsPrimitive stem cellsEmbryonic developmentSignaling moleculesDiverse tissuesCell body clustersProgenitor cellsNeurite bundlesGrowth factorProgenitorsCell-friendly microenvironmentCellsDifferentiationExogenous cytokinesImportant roleBody clustersSpatial gradients
2007
Directed differentiation of human embryonic stem cells towards a pancreatic cell fate
Shim J, Kim S, Woo D, Kim S, Oh C, McKay R, Kim J. Directed differentiation of human embryonic stem cells towards a pancreatic cell fate. Diabetologia 2007, 50: 1228-1238. PMID: 17457565, DOI: 10.1007/s00125-007-0634-z.Peer-Reviewed Original ResearchMeSH KeywordsActivinsAnimalsCell Culture TechniquesCell DifferentiationDiabetes Mellitus, ExperimentalEmbryonic Stem CellsGene Expression RegulationHomeodomain ProteinsHumansMaleMiceMice, Inbred BALB CMice, NudePancreasReverse Transcriptase Polymerase Chain ReactionStem Cell TransplantationTrans-ActivatorsTransplantation, HeterologousTretinoinConceptsHuman embryonic stem cellsPdx1-positive cellsForkhead box protein A2Embryonic stem cellsEndodermal cellsCaudal-type homeobox transcription factor 2Differentiation of hESCsCell typesPancreatic cell fateRetinoic acidStem cellsMature cell typesEmbryonic germ layersEmbryoid body formationPancreatic cell typesBox protein A2Transcription factor 2Vivo pancreatic developmentEpigenetic signalsCell fateEctodermal differentiationDuodenal homeobox 1Pancreatic fateGene 17Gene expressionComparative Analysis of the Developmental Competence of Three Human Embryonic Stem Cell Lines in Vitro
Kim S, Kim B, Gil J, Kim S, Kim J. Comparative Analysis of the Developmental Competence of Three Human Embryonic Stem Cell Lines in Vitro. Molecules And Cells 2007, 23: 49-56. PMID: 17464211, DOI: 10.1016/s1016-8478(23)07388-0.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cellsHESC linesHuman embryonic stem cell linesEmbryonic stem cell linesPrimordial germ cellsDevelopmental potentialEmbryonic stem cellsEmbryonic germ layersEmbryoid body formationSpecific cell typesDevelopmental competenceStem cell linesCell replacement therapyExtraembryonic tissuesStem cell technologyGerm layersTerminal differentiationGerm cellsBody formationPluripotency markersCell typesNeuronal cellsTelomerase activityStem cellsHSF6
2006
Nonylphenol and Octylphenol-Induced Apoptosis in Human Embryonic Stem Cells Is Related to Fas-Fas Ligand Pathway
Kim S, Kim B, Shim J, Gil J, Yoon Y, Kim J. Nonylphenol and Octylphenol-Induced Apoptosis in Human Embryonic Stem Cells Is Related to Fas-Fas Ligand Pathway. Toxicological Sciences 2006, 94: 310-321. PMID: 16984955, DOI: 10.1093/toxsci/kfl114.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cellsUndifferentiated hES cellsEmbryonic stem cellsHES cellsNeural progenitor cellsEarly embryonic developmentStem cellsProgenitor cellsToxic stress responseChemical-induced apoptosisFas ligand protein expressionFas-Fas ligand pathwayCell replacement therapyEmbryonic developmentCaspase activationES cellsCaspase-8Stress responseDevelopmental stagesDNA fragmentationCell typesFas-FasL interactionCommon environmental contaminantsApoptosisProtein expression