Stavroula Hatzios, PhD
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About
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Associate Professor of Molecular, Cellular and Developmental Biology and of Chemistry
Education & Training
- Postdoctoral Fellow
- Brigham and Women's Hospital/Harvard Medical School (2016)
- PhD
- University of California, Berkeley, Chemistry (2010)
- BS
- Massachusetts Institute of Technology, Chemistry (2005)
Research
Overview
Medical Subject Headings (MeSH)
Bacteria; Biochemistry; Enzyme Activation; Gastrointestinal Diseases; Host-Pathogen Interactions; Microbiology
ORCID
0000-0001-8658-8949
Research at a Glance
Yale Co-Authors
Frequent collaborators of Stavroula Hatzios's published research.
Publications Timeline
A big-picture view of Stavroula Hatzios's research output by year.
Research Interests
Research topics Stavroula Hatzios is interested in exploring.
Carmen Jane Booth, DVM, PhD
14Publications
4,862Citations
Host-Pathogen Interactions
Publications
2023
Chemical Tools for Decoding Redox Signaling at the Host–Microbe Interface
Gordon E, Hatzios S. Chemical Tools for Decoding Redox Signaling at the Host–Microbe Interface. 2023, 1017-1024. DOI: 10.1201/9781003298038-37.Peer-Reviewed Original ResearchIsotope tracing reveals bacterial catabolism of host-derived glutathione during Helicobacter pylori infection
Baskerville M, Kovalyova Y, Mejías-Luque R, Gerhard M, Hatzios S. Isotope tracing reveals bacterial catabolism of host-derived glutathione during Helicobacter pylori infection. PLOS Pathogens 2023, 19: e1011526. PMID: 37494402, PMCID: PMC10406306, DOI: 10.1371/journal.ppat.1011526.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsH. pylori infectionPylori infectionInfected cellsBacterial catabolismGastric pathogen Helicobacter pyloriGSH depletionPathogen Helicobacter pyloriH. pylori-infected cellsMammalian cellsReactive oxygen speciesHelicobacter pylori infectionH. pylori colonizationCellular biomoleculesGSH homeostasisBacterial acquisitionCertain bacteriaVirulence factorsAntioxidant glutathioneIntracellular GSHOxidative damageOxidized GSHΓ-glutamyl transpeptidaseIsotope tracingHost tissuesOxygen speciesMoonlighting in the membrane
Hatzios S. Moonlighting in the membrane. Nature Chemical Biology 2023, 19: 1436-1437. PMID: 37349584, DOI: 10.1038/s41589-023-01369-4.Commentaries, Editorials and LettersEmerging roles of low-molecular-weight thiols at the host–microbe interface
Dumitrescu D, Hatzios S. Emerging roles of low-molecular-weight thiols at the host–microbe interface. Current Opinion In Chemical Biology 2023, 75: 102322. PMID: 37201290, PMCID: PMC10524283, DOI: 10.1016/j.cbpa.2023.102322.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHost-microbe interfaceLMW thiolsWeight thiolsCellular redox homeostasisRedox-active metabolitesCellular physiologyVirulence regulationRedox homeostasisHost physiologyAbundant classMicrobial metabolismHost cellsIntercellular interactionsForms of lifeInfected cellsSmall moleculesPhysiologyCellsComputational approachThiolsHomeostasisRegulationRoleMetabolismDiscoveryActivity‐based Tools for Interrogating Host Biology During Infection
Ramanathan R, Hatzios S. Activity‐based Tools for Interrogating Host Biology During Infection. Israel Journal Of Chemistry 2023, 63 PMID: 37744997, PMCID: PMC10512441, DOI: 10.1002/ijch.202200095.Peer-Reviewed Original ResearchCitationsAltmetricConceptsActivity-based protein profilingPost-translational modificationsHost post-translational modificationsHost-microbe interactionsHost biologyCells senseCell signalingMicrobial mechanismsEnzyme functionProtein profilingProtein structureSide-chain reactivityChemical probesInfected cellsHost-directed therapiesPotential targetRapid modulationHost responseSignalingBiologyInfectionEnzymeProfilingPathwayPathogens
2022
A microbial transporter of the dietary antioxidant ergothioneine
Dumitrescu D, Gordon E, Kovalyova Y, Seminara A, Duncan-Lowey B, Forster E, Zhou W, Booth C, Shen A, Kranzusch P, Hatzios S. A microbial transporter of the dietary antioxidant ergothioneine. Cell 2022, 185: 4526-4540.e18. PMID: 36347253, PMCID: PMC9691600, DOI: 10.1016/j.cell.2022.10.008.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsInter-kingdom competitionHost-associated microbesIntracellular redox homeostasisGastric pathogen Helicobacter pyloriPathogen Helicobacter pyloriRedox regulationSmall molecule antioxidantsRedox homeostasisBiosynthetic pathwayColonization advantageUnappreciated mechanismLMW thiolsHost environmentHuman faecal bacteriaWeight thiolsCertain microorganismsAntioxidant ergothioneineGastrointestinal microbesMetabolite trimethylamine N-oxideMicrobesMillimolar levelsHuman tissuesErgothioneineTrimethylamine N-oxideFecal bacteriaA propeptide-based biosensor for the selective detection of Vibrio cholerae using an environment-sensitive fluorophore
DeColli AA, Koolik IM, Seminara AB, Hatzios SK. A propeptide-based biosensor for the selective detection of Vibrio cholerae using an environment-sensitive fluorophore. Cell Chemical Biology 2022, 29: 1505-1516.e7. PMID: 36270233, DOI: 10.1016/j.chembiol.2022.09.003.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsAn infection-induced oxidation site regulates legumain processing and tumor growth
Kovalyova Y, Bak DW, Gordon EM, Fung C, Shuman JHB, Cover TL, Amieva MR, Weerapana E, Hatzios SK. An infection-induced oxidation site regulates legumain processing and tumor growth. Nature Chemical Biology 2022, 18: 698-705. PMID: 35332331, PMCID: PMC9246868, DOI: 10.1038/s41589-022-00992-x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCysteine reactivityOxidation sitesTumor growthChemical proteomicsH. pylori-infected cellsRedox-sensitive cysteinesInduces oxidationReactivityOxidationOxidation EventHuman gastric cellsCarcinogenic infectionsBacterium Helicobacter pyloriXenograft modelHelicobacter pyloriSite-specific lossGastric cellsMost cancersOxidative stressReactive oxygen speciesTumor formationOxygen speciesInfectionTumorigenesisCysteine
2020
Chemical tools for decoding redox signaling at the host–microbe interface
Gordon EM, Hatzios SK. Chemical tools for decoding redox signaling at the host–microbe interface. PLOS Pathogens 2020, 16: e1009070. PMID: 33332456, PMCID: PMC7745962, DOI: 10.1371/journal.ppat.1009070.Peer-Reviewed Original ResearchCitationsAltmetric
2019
Functional characterization of a subtilisin-like serine protease from Vibrio cholerae
Howell M, Dumitrescu DG, Blankenship LR, Herkert D, Hatzios SK. Functional characterization of a subtilisin-like serine protease from Vibrio cholerae. Journal Of Biological Chemistry 2019, 294: 9888-9900. PMID: 31076508, PMCID: PMC6597830, DOI: 10.1074/jbc.ra119.007745.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSubtilisin-like enzymesSerine proteasesSubtilisin-like serine proteaseProtein domain structureDiarrheal disease choleraSerine hydrolase activityNutrient acquisitionAquatic nichesCarbohydrate-binding proteinsPathogen enzymesMature enzymeReporter proteinBiofilm assemblyFunctional characterizationNumerous enzymesDisease choleraCleavage eventsIntelectinLarge familyStepwise processingVibrio choleraeCleavage patternsEnzymeProteaseHydrolase activity
Academic Achievements and Community Involvement
honor Young Investigator Award
National AwardACS Infectious Diseases and American Chemical Society Division of Biological ChemistryDetails08/13/2023honor Conquer Cancer Now Award
National AwardThe Concern FoundationDetails10/01/2020United Stateshonor Maximizing Investigators’ Research Award (MIRA) for Early Stage Investigators
National AwardNational Institute of General Medical SciencesDetails08/05/2020United Stateshonor Beckman Young Investigator Award
National AwardArnold and Mabel Beckman FoundationDetails05/20/2020United Stateshonor Scialog Fellow: Microbiome, Neurobiology, and Disease
National AwardResearch Corporation for Science AdvancementDetails02/10/2020United States
Links & Media
News
- January 03, 2023Source: SciTechDaily
Shocking Yale Research: Common Nutrient Found To Aid Survival of Cancer-Causing Bacterium
- November 07, 2022Source: Yale West Campus
Role of Nutrient May Reveal Dietary Target in Fight Against Microbial Infections
- March 24, 2022
Yale Scientists Deploy Chemical Tools to Detect Cancer-causing Proteins
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West Campus Advanced Biosciences Center
840 West Campus Drive
West Haven, CT 06516
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