2024
The Case | An active injection drug user with a skin rash and kidney failure
Aron A, Luciano R. The Case | An active injection drug user with a skin rash and kidney failure. Kidney International 2024, 105: 1327-1328. PMID: 38777409, DOI: 10.1016/j.kint.2024.03.009.Peer-Reviewed Original ResearchIdentification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis
Moledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, Kashgarian M, Kuperman M, Campbell K, Lefferts S, Meliambro K, Bitzer M, Perazella M, Luciano R, Pober J, Cantley L, Colvin R, Wilson F, Parikh C. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis. Journal Of Clinical Investigation 2024, 134: e180583. PMID: 38488004, PMCID: PMC10940080, DOI: 10.1172/jci180583.Peer-Reviewed Original ResearchRationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis
Barsotti G, Luciano R, Kumar A, Meliambro K, Kakade V, Tokita J, Naik A, Fu J, Peck E, Pell J, Reghuvaran A, Tanvir E, Patel P, Zhang W, Li F, Moeckel G, Perincheri S, Cantley L, Moledina D, Wilson F, He J, Menon M. Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis. Kidney International Reports 2024, 9: 1354-1368. PMID: 38707807, PMCID: PMC11068976, DOI: 10.1016/j.ekir.2024.02.006.Peer-Reviewed Original ResearchMinimal change diseaseRandomized controlled trialsSafety of metforminDouble-blindPodocyte injuryAdjunctive therapyPlacebo-controlled randomized controlled trialsPhase III studyPhase II trialPrimary glomerular diseaseFocal segmental glomerulosclerosisEffect of metforminPhase IIPlacebo-controlledPreclinical dataNovel urineChange diseaseTissue markersRandomized trialsSegmental glomerulosclerosisGlomerular diseaseMechanistic biomarkersObservational studyFSGSInexpensive agent
2023
Guillain-Barre Syndrome Presenting Alongside Lupus Nephritis: Case and Management
Mehta P, Luciano R, Aklilu A, Malvar G. Guillain-Barre Syndrome Presenting Alongside Lupus Nephritis: Case and Management. Journal Of The American Society Of Nephrology 2023, 34: 277-277. DOI: 10.1681/asn.20233411s1277a.Peer-Reviewed Original ResearchDiffuse Alveolar Hemorrhage Presenting in IgA Nephropathy
Jobson C, Luciano R, Shirali A, Malvar G. Diffuse Alveolar Hemorrhage Presenting in IgA Nephropathy. Journal Of The American Society Of Nephrology 2023, 34: 1119-1119. DOI: 10.1681/asn.20233411s11119a.Peer-Reviewed Original Research
2022
Safety and Adequacy of Kidney Biopsy Procedure in Patients With Obesity
Qian L, Weinstein J, Melchinger H, Hu D, Menez S, Philbrook H, Luciano R, Perazella M, Shaw M, Parikh C, Wilson F, Moledina D. Safety and Adequacy of Kidney Biopsy Procedure in Patients With Obesity. Journal Of The American Society Of Nephrology 2022, 33: 207-207. DOI: 10.1681/asn.20223311s1207b.Peer-Reviewed Original ResearchResults of Patient Experience Surveys 30 Days After Kidney Biopsy
Melchinger H, Weinstein J, Gutierrez F, Shaw M, Kent C, Luciano R, Wilson F, Moledina D. Results of Patient Experience Surveys 30 Days After Kidney Biopsy. Journal Of The American Society Of Nephrology 2022, 33: 898-898. DOI: 10.1681/asn.20223311s1898a.Peer-Reviewed Original ResearchAA Amyloidosis Presenting With Renal Amyloidoma
Gunasekaran D, Luciano R. AA Amyloidosis Presenting With Renal Amyloidoma. Journal Of The American Society Of Nephrology 2022, 33: 167-168. DOI: 10.1681/asn.20223311s1167e.Peer-Reviewed Original ResearchPeritoneal Dialysis Should Be Considered the First Option for Patients Requiring Urgent Start Dialysis: CON
Luciano R. Peritoneal Dialysis Should Be Considered the First Option for Patients Requiring Urgent Start Dialysis: CON. Kidney360 2022, 4: 138-140. PMID: 36821605, PMCID: PMC10103267, DOI: 10.34067/kid.0007822021.Peer-Reviewed Original Research
2020
Evaluation of a Direct-to-Digital Histology Method for Rapid Evaluation of Kidney Biopsies
Perincheri S, Luciano R, Moeckel G, Torres R. Evaluation of a Direct-to-Digital Histology Method for Rapid Evaluation of Kidney Biopsies. Journal Of The American Society Of Nephrology 2020, 31: 13-13. DOI: 10.1681/asn.20203110s113b.Peer-Reviewed Original Research
2014
Nephrotoxic effects of designer drugs: synthetic is not better!
Luciano RL, Perazella MA. Nephrotoxic effects of designer drugs: synthetic is not better! Nature Reviews Nephrology 2014, 10: 314-324. PMID: 24662435, DOI: 10.1038/nrneph.2014.44.BooksKidney Involvement in Leukemia and Lymphoma
Luciano RL, Brewster UC. Kidney Involvement in Leukemia and Lymphoma. Advances In Kidney Disease And Health 2014, 21: 27-35. PMID: 24359984, DOI: 10.1053/j.ackd.2013.07.004.BooksConceptsAcute kidney injuryKidney involvementOvert kidney failureAcute tubular necrosisMultiorgan system involvementLife-threatening consequencesForms of leukemiaAcid-base disordersObstructive etiologyKidney injuryElectrolyte disturbancesTubular necrosisCommon etiologyNephrotic syndromeKidney failureSystem involvementHematologic malignanciesSide effectsDirect effectMalignancyAge groupsLymphomaLeukemiaComplicationsEtiology
2013
Acute Kidney Injury From Cherry Concentrate in a Patient With CKD
Luciano RL. Acute Kidney Injury From Cherry Concentrate in a Patient With CKD. American Journal Of Kidney Diseases 2013, 63: 503-505. PMID: 24290246, DOI: 10.1053/j.ajkd.2013.09.021.Peer-Reviewed Case Reports and Technical NotesConceptsAcute kidney injuryKidney injuryKidney diseaseNonsteroidal anti-inflammatory medicationsAnti-inflammatory medicationsChronic kidney diseaseCherry concentrateMethod of injuryMultiple organ systemsMechanism of actionSignificant morbidityHarmful side effectsCyclooxygenase inhibitionNumerous health benefitsMedical foodsSide effectsOrgan systemsHyperkalemiaInjuryPatientsDaily consumptionAdverse effectsHealth benefitsCherry extractDiseaseExtra-renal manifestations of autosomal dominant polycystic kidney disease (ADPKD): considerations for routine screening and management
Luciano RL, Dahl NK. Extra-renal manifestations of autosomal dominant polycystic kidney disease (ADPKD): considerations for routine screening and management. Nephrology Dialysis Transplantation 2013, 29: 247-254. PMID: 24215018, DOI: 10.1093/ndt/gft437.Peer-Reviewed Educational MaterialsConceptsAutosomal dominant polycystic kidney diseaseEnd-stage renal diseaseChronic kidney diseaseExtra-renal manifestationsKidney diseasePolycystic kidney diseaseDisease burdenRenal cystsBilateral renal cystsCurrent screening recommendationsDominant polycystic kidney diseaseExtra-renal diseaseDiverticular diseaseRenal diseaseScreening recommendationsSystemic diseaseADPKD patientsRoutine screeningMale infertilityDiseaseProgressive increasePatientsCystsManifestationsBurdenWarfarin-related nephropathy in a patient with mild IgA nephropathy on dabigatran and aspirin
Moeckel GW, Luciano RL, Brewster UC. Warfarin-related nephropathy in a patient with mild IgA nephropathy on dabigatran and aspirin. Clinical Kidney Journal 2013, 6: 507-509. PMID: 26120444, PMCID: PMC4438392, DOI: 10.1093/ckj/sft076.Peer-Reviewed Case Reports and Technical NotesAcute kidney injuryTubular injuryIgA nephropathyMild IgA nephropathyAcute tubular injuryLong-term anticoagulationDirect thrombin inhibitorKidney injurySevere hematuriaRenal biopsyGlomerular pathologyDabigatranPatientsThrombin inhibitorsNephropathyInjuryWarfarinAnticoagulationHematuriaAspirinBiopsyPathologyBabesiosis-Induced Acute Kidney Injury With Prominent Urinary Macrophages
Luciano RL, Moeckel G, Palmer M, Perazella MA. Babesiosis-Induced Acute Kidney Injury With Prominent Urinary Macrophages. American Journal Of Kidney Diseases 2013, 62: 801-805. PMID: 23643302, DOI: 10.1053/j.ajkd.2013.02.376.Peer-Reviewed Case Reports and Technical NotesConceptsAcute kidney injuryAcute tubular injuryKidney injuryTubular injuryDialysis-requiring acute kidney injuryAcute interstitial nephritisMultiorgan system failureSubsequent kidney biopsySevere symptomatic diseaseUrinary macrophagesUrinary findingsInterstitial nephritisKidney biopsySymptomatic diseaseMassive hemolysisSevere babesiosisVolume depletionCommon causeProfound hemolysisErythrocyte fragmentsUrine sedimentInjuryLarge macrophagesPigment toxicityUnique findingNSAIDs: Acute kidney injury (acute renal failure)
Luciano RL, Perazella MA. (2013) NSAIDs: Acute kidney injury (acute renal failure). In: UpToDate, Palevsky PM (Ed), UpToDate, Wlatham, MA.Books
2012
A Dysfunctional Peritoneal Dialysis Catheter: Imaging the Problem
Luciano RL, Brewster UC. A Dysfunctional Peritoneal Dialysis Catheter: Imaging the Problem. Seminars In Dialysis 2012, 25: 560-561. PMID: 22780865, DOI: 10.1111/j.1525-139x.2012.01108.x.Peer-Reviewed Case Reports and Technical Notes
2011
Risk of Poor Outcomes with Novel and Traditional Biomarkers at Clinical AKI Diagnosis
Hall IE, Coca SG, Perazella MA, Eko UU, Luciano RL, Peter PR, Han WK, Parikh CR. Risk of Poor Outcomes with Novel and Traditional Biomarkers at Clinical AKI Diagnosis. Clinical Journal Of The American Society Of Nephrology 2011, 6: 2740-2749. PMID: 22034509, PMCID: PMC3255362, DOI: 10.2215/cjn.04960511.Peer-Reviewed Original ResearchConceptsKidney injury molecule-1Neutrophil gelatinase-associated lipocalinAcute kidney injuryAcute tubular necrosisMicroscopy scorePrimary outcomeIL-18Prognostic utilityClinical assessmentInjury molecule-1Peak serum creatinineProspective cohort studyGelatinase-associated lipocalinFirst dayUrine protein biomarkersProtein biomarker concentrationsAKI criteriaAKI diagnosisAKI stageBaseline GFRHospital deathKidney injuryCohort studySerum creatinineTubular necrosis