2024
Impact of Early Intervention on Health Status Outcomes in Peripheral Artery Disease Patients with Chronic Total Occlusion Lesions Using the PORTRAIT Registry
Cerrud-Rodriguez R, Romain G, Hussain Y, Cleman J, Callegari S, Scierka L, Smolderen K, Mena-Hurtado C. Impact of Early Intervention on Health Status Outcomes in Peripheral Artery Disease Patients with Chronic Total Occlusion Lesions Using the PORTRAIT Registry. Journal Of Vascular Surgery 2024 PMID: 38735596, DOI: 10.1016/j.jvs.2024.04.061.Peer-Reviewed Original ResearchPeripheral Artery QuestionnairePeripheral arterial diseaseHealth statusChronic total occlusionChronic total occlusion lesionsPAD-specific health statusEarly invasive treatmentMultilevel generalized linear regression modelsPeripheral arterial disease symptomsLower extremity peripheral arterial diseaseBaseline health statusHealth status outcomesInvasive treatmentHealth status trajectoriesNon-invasive treatmentPatients' health statusImpact of early interventionHigh health statusFollow-upPeripheral arterial disease patientsSymptomatic peripheral arterial diseaseMonths of follow-upPresence of chronic total occlusionNon-invasive treatment strategyStatus outcomesPsychosocial and socioeconomic factors are most predictive of health status in patients with claudication
Scierka L, Peri-Okonny P, Romain G, Cleman J, Spertus J, Fitridge R, Secemsky E, Patel M, Gosch K, Mena-Hurtado C, Smolderen K. Psychosocial and socioeconomic factors are most predictive of health status in patients with claudication. Journal Of Vascular Surgery 2024, 79: 1473-1482.e5. PMID: 38266885, PMCID: PMC11180544, DOI: 10.1016/j.jvs.2024.01.021.Peer-Reviewed Original ResearchPeripheral Artery QuestionnairePeripheral Artery Questionnaire summary scoresPeripheral arterial diseaseHealth statusSummary scoreSymptomatic peripheral arterial diseaseSocial supportInsurance statusPAD-specific health statusHierarchical multivariable linear regression modelSocioeconomic patient characteristicsLow social supportPeripheral artery disease cohortPeripheral artery questionnaire scoresImprove health statusComparative effectiveness researchDiagnosis of depressionPatient characteristicsMultivariate linear regression modelPrediction of health statusDepression scoresLinear regression modelsAge of patientsDuration of symptomsAnxiety scores
2022
One-Year Health Status Outcomes Following Early Invasive and Noninvasive Treatment in Symptomatic Peripheral Artery Disease
Angraal S, Hejjaji V, Tang Y, Gosch KL, Patel MR, Heyligers J, White CJ, Nolthenius R, Mena-Hurtado C, Aronow HD, Moneta GL, Fitridge R, Soukas PA, Abbott JD, Secemsky EA, Spertus JA, Smolderen KG. One-Year Health Status Outcomes Following Early Invasive and Noninvasive Treatment in Symptomatic Peripheral Artery Disease. Circulation Cardiovascular Interventions 2022, 15: e011506. PMID: 35579010, PMCID: PMC11299756, DOI: 10.1161/circinterventions.121.011506.Peer-Reviewed Original ResearchConceptsHealth status outcomesPropensity-matched sampleEarly invasiveHealth statusEarly revascularizationStatus outcomesSymptomatic peripheral artery diseaseDisease-specific health statusNoninvasive management strategiesPeripheral Artery QuestionnaireTreatment-resistant symptomsEarly invasive managementPeripheral artery diseaseBaseline health statusEarly invasive treatmentHealth status trajectoriesHealth status improvementReal-world evidencePORTRAIT registryArtery diseaseInvasive managementNoninvasive managementPatient preferencesInvasive treatmentLifestyle changes
2021
Patient-Reported Outcome Measures in Symptomatic, Non–Limb-Threatening Peripheral Artery Disease: A State-of-the-Art Review
Rymer JA, Narcisse D, Cosiano M, Tanaka J, McDermott MM, Treat-Jacobson DJ, Conte MS, Tuttle B, Patel MR, Smolderen KG. Patient-Reported Outcome Measures in Symptomatic, Non–Limb-Threatening Peripheral Artery Disease: A State-of-the-Art Review. Circulation Cardiovascular Interventions 2021, 15: e011320. PMID: 34937395, DOI: 10.1161/circinterventions.121.011320.Peer-Reviewed Original ResearchConceptsPatient-reported outcome measuresPeripheral artery diseaseDisease-specific patient-reported outcome measureSymptomatic peripheral artery diseaseArtery diseaseOutcome measuresSelection of PROMsDisease-specific Peripheral Artery QuestionnairePeripheral Artery QuestionnaireLimb-threatening ischemiaValidation of PROMsVascular QualityImpairment QuestionnaireSF-36Life QuestionnaireInclusion criteriaCurrent evidenceEffects of diseaseHealth outcomesEuropean QualityClinical goalsLiterature searchPatientsDiseasePsychometric validationAssociation of sleep apnea with outcomes in peripheral artery disease: Insights from the PORTRAIT study
Jelani QU, Mena-Hurtado C, Gosch K, Mohammed M, Labrosciano C, Regan C, Scierka LE, Spertus JA, Nagpal S, Smolderen KG. Association of sleep apnea with outcomes in peripheral artery disease: Insights from the PORTRAIT study. PLOS ONE 2021, 16: e0256933. PMID: 34506511, PMCID: PMC8432750, DOI: 10.1371/journal.pone.0256933.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePeripheral Artery QuestionnaireSleep apneaHealth statusArtery diseaseSummary scoresDisease-specific Peripheral Artery QuestionnaireFive-year survival curvesHigh ankle-brachial indexPAQ summary scoreVascular specialty clinicsAnkle-brachial indexLog-rank testSleep apnea statusHealth status outcomesWorse health statusQuality of lifeBetter health statusCause mortalityMultivariable adjustmentPAD symptomsCoronary diseasePeripheral interventionsUS patientsMean ageEstablishing Thresholds for Minimal Clinically Important Differences for the Peripheral Artery Disease Questionnaire
Peri-Okonny PA, Wang J, Gosch KL, Patel MR, Shishehbor MH, Safley DL, Abbott JD, Aronow HD, Mena-Hurtado C, Jelani QU, Tang Y, Bunte M, Labrosciano C, Beltrame JF, Spertus JA, Smolderen KG. Establishing Thresholds for Minimal Clinically Important Differences for the Peripheral Artery Disease Questionnaire. Circulation Cardiovascular Quality And Outcomes 2021, 14: e007232. PMID: 33947205, PMCID: PMC8254614, DOI: 10.1161/circoutcomes.120.007232.Peer-Reviewed Original ResearchConceptsPAQ summary scorePeripheral Artery QuestionnaireGlobal assessmentPatient's perspectiveSummary scoresDisease-specific health status instrumentHealth status assessment toolMinimal Clinically Important DifferencePAQ scoresPatient-reported outcomesRoutine clinical careHealth status instrumentsClinically Important DifferenceMultivariable linear regressionPORTRAIT registryDisease QuestionnaireMultivariable adjustmentVascular clinicMean ageUS cohortClinical trialsClinical careMCIDMCID estimatesMean difference
2020
Relationship Between Depressive Symptoms and Health Status in Peripheral Artery Disease: Role of Sex Differences
Jelani Q, Mena‐Hurtado C, Burg M, Soufer R, Gosch K, Jones PG, Spertus JA, Safdar B, Smolderen KG. Relationship Between Depressive Symptoms and Health Status in Peripheral Artery Disease: Role of Sex Differences. Journal Of The American Heart Association 2020, 9: e014583. PMID: 32781883, PMCID: PMC7660812, DOI: 10.1161/jaha.119.014583.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseDepressive symptomsHealth statusArtery diseaseEQ-5D visual analog scale scoresEQ-5D visual analog scaleVisual analog scale scoreGeneric health statusPeripheral Artery QuestionnaireVascular specialty clinicsAnalog scale scoreHealth status scoresPatient Health QuestionnaireSevere depressive symptomsVisual analog scaleHealth status outcomesWorse health statusAdjusted general linear modelSex differencesPORTRAIT registryPAD diagnosisPAD symptomsAnalog scaleConclusions WomenMean agePatient profiles and health status outcomes for peripheral artery disease in high-income countries: a comparison between the USA and The Netherlands
Jelani QU, Smolderen KG, Halpin D, Gosch K, Spertus JA, Chaar C, Nolthenius R, Heyligers J, De Vries JP, Mena-Hurtado C. Patient profiles and health status outcomes for peripheral artery disease in high-income countries: a comparison between the USA and The Netherlands. European Heart Journal - Quality Of Care And Clinical Outcomes 2020, 7: 505-512. PMID: 32539108, DOI: 10.1093/ehjqcco/qcaa052.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseHealth status scoresHealth status outcomesStatus scoreStatus outcomesArtery diseaseUS patientsHigh-income countriesPatient profilesCardiovascular risk factor burdenPAD-specific health statusPeripheral Artery QuestionnaireRisk factor burdenVascular specialty clinicsPeripheral arterial diseasePatient-centered outcomesLow referral ratesMore financial barriersPAD carePAD outcomesNew onsetPAD symptomsArterial diseaseExercise treatmentReferral ratesCilostazol and peripheral artery disease-specific health status in ambulatory patients with symptomatic PAD
Mohammed M, Gosch K, Safley D, Jelani QU, Aronow HD, Mena C, Shishehbor MH, Spertus JA, Abbott JD, Smolderen KG. Cilostazol and peripheral artery disease-specific health status in ambulatory patients with symptomatic PAD. International Journal Of Cardiology 2020, 316: 222-228. PMID: 32464249, DOI: 10.1016/j.ijcard.2020.05.042.Peer-Reviewed Original ResearchConceptsPeripheral Artery QuestionnaireHealth statusDisease-specific health statusPatient-reported health statusHeart failure historyNon-cilostazol groupUse of cilostazolPAQ scoresImprovement of symptomsSubsequent health statusQuality of lifeCilostazol therapyCilostazol useSymptomatic PADPatient characteristicsPharmacological optionsAmbulatory patientsLimitation scoresMean ageFunctional statusUS cohortTreatment goalsSummary scoresCilostazolPatientsLevel of disease and association with health status in patients presenting with claudication from the PORTRAIT registry
Vogel TR, Braet DJ, Kruse RL, Bath J, Wang J, Gosch K, Smolderen KG. Level of disease and association with health status in patients presenting with claudication from the PORTRAIT registry. Journal Of Vascular Surgery 2020, 72: 2017-2026. PMID: 32325227, DOI: 10.1016/j.jvs.2020.03.042.Peer-Reviewed Original ResearchMeSH KeywordsAgedFemaleFunctional StatusHealth Status IndicatorsHumansIntermittent ClaudicationMaleMiddle AgedPatient SatisfactionPeripheral Arterial DiseasePredictive Value of TestsQuality of LifeRegistriesRetrospective StudiesSeverity of Illness IndexSurveys and QuestionnairesTime FactorsTreatment OutcomeConceptsPeripheral artery diseasePAQ summary scorePeripheral Artery QuestionnaireQuality of lifeAnkle-brachial indexMultilevel diseaseAortoiliac diseaseHealth statusAnatomic levelSummary scoresMedical managementHigh ankle-brachial indexFemoral-popliteal diseaseTreatment of aortoiliacChronic kidney diseaseHistory of diabetesPAQ scoresPeripheral arterial diseaseOverall health statusSimilar health statusHealth status informationStudent's t-testLevel of diseaseRepeated-measures analysisInfrapopliteal disease
2019
Financial barriers in accessing medical care for peripheral artery disease are associated with delay of presentation and adverse health status outcomes in the United States
Jelani QU, Jhamnani S, Spatz ES, Spertus J, Smolderen KG, Wang J, Desai NR, Jones P, Gosch K, Shah S, Attaran R, Mena-Hurtado C. Financial barriers in accessing medical care for peripheral artery disease are associated with delay of presentation and adverse health status outcomes in the United States. Vascular Medicine 2019, 25: 13-24. PMID: 31603393, DOI: 10.1177/1358863x19872542.Peer-Reviewed Original ResearchMeSH KeywordsAgedFemaleHealth Care CostsHealth Services AccessibilityHealth Status DisparitiesHealthcare DisparitiesHumansInsurance, HealthMaleMedically UninsuredMiddle AgedPatient Reported Outcome MeasuresPeripheral Arterial DiseaseProspective StudiesQuality of LifeRisk FactorsTime FactorsTime-to-TreatmentUnited StatesConceptsPeripheral artery diseasePeripheral Artery QuestionnaireHealth status outcomesHealth statusArtery diseaseStatus outcomesFinancial barriersGeneral health-related qualityDisease-specific health statusPatient-reported health statusDelay of presentationPatient-reported difficultyVascular specialty clinicsPeripheral arterial diseaseEuroQol-5 DimensionsHealth-related qualityPoor health statusUnited States patientsMulticenter registryMultivariable adjustmentPAD symptomsArterial diseaseTreatment patternsUS patientsLate presentationAnkle-brachial index in patients with intermittent claudication is a poor indicator of patient-centered and clinician-based evaluations of functional status
Johnston AL, Vemulapalli S, Gosch KL, Aronow HD, Abbott JD, Patel MR, Smolderen KG, Shishebor M, Spertus JA, Jones WS. Ankle-brachial index in patients with intermittent claudication is a poor indicator of patient-centered and clinician-based evaluations of functional status. Journal Of Vascular Surgery 2019, 69: 906-912. PMID: 30626552, DOI: 10.1016/j.jvs.2018.07.039.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnkle Brachial IndexAustraliaCost of IllnessFemaleHealth StatusHemodynamicsHumansIntermittent ClaudicationMaleMiddle AgedNetherlandsPatient Reported Outcome MeasuresPeripheral Arterial DiseasePredictive Value of TestsProspective StudiesQuality of LifeRegistriesSeverity of Illness IndexUnited StatesConceptsAnkle-brachial indexPeripheral artery diseasePeripheral Artery QuestionnaireIntermittent claudicationRutherford classificationABI valuesPAQ scoresArtery diseaseImpact of PADHealth statusMean ankle-brachial indexPAD-specific health statusSevere peripheral artery diseasePAQ summary scoreStudy of patientsQuality of lifeHealth status assessmentRutherford classNew onsetPatient's symptomsHemodynamic assessmentLife scoresFunctional statusPatients' perceptionsInternational cohort
2018
Associations of exercise ankle–brachial index, pain-free walking distance and maximum walking distance with the Peripheral Artery Questionnaire: Finding from the PORTRAIT PAD Registry
Hammad TA, Smolderen KG, Spertus JA, Jones PG, Shishehbor MH. Associations of exercise ankle–brachial index, pain-free walking distance and maximum walking distance with the Peripheral Artery Questionnaire: Finding from the PORTRAIT PAD Registry. Vascular Medicine 2018, 24: 32-40. PMID: 29992849, DOI: 10.1177/1358863x18785026.Peer-Reviewed Original ResearchConceptsPain-free walking distancePeripheral artery diseaseMaximum walking distancePeripheral Artery QuestionnairePhysical limitation scoreWalking distancePatient factorsLimitation scoresImpact of PADAnkle-brachial index (ABI) testExercise ankle-brachial indexOnset of claudicationPost-exercise ABIAnkle-brachial indexQuality of lifeHierarchical logistic regression modelsLogistic regression modelsPORTRAIT registryArtery diseasePatient's symptomsPatient functioningABI testingSummary scoresHealth statusSymptoms
2017
Sex differences in disease-specific health status measures in patients with symptomatic peripheral artery disease: Data from the PORTRAIT study
Roumia M, Aronow HD, Soukas P, Gosch K, Smolderen KG, Spertus JA, Abbott JD. Sex differences in disease-specific health status measures in patients with symptomatic peripheral artery disease: Data from the PORTRAIT study. Vascular Medicine 2017, 22: 103-109. PMID: 28429659, DOI: 10.1177/1358863x16686408.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnkle Brachial IndexAustraliaChi-Square DistributionCost of IllnessFemaleHealth Status DisparitiesHealth Status IndicatorsHumansIntermittent ClaudicationLinear ModelsLogistic ModelsMaleMental HealthMiddle AgedMultivariate AnalysisNetherlandsPatient SatisfactionPeripheral Arterial DiseasePrognosisProspective StudiesQuality of LifeRisk FactorsSeverity of Illness IndexSex FactorsSocial BehaviorSocioeconomic FactorsSurveys and QuestionnairesUnited StatesConceptsPeripheral artery diseasePeripheral Artery QuestionnaireHealth statusArtery diseaseSymptoms of PADAnkle-brachial index valuesPAD-specific health statusSymptomatic peripheral artery diseaseDisease-specific health status measuresPAQ scoresPeripheral arterial diseaseSex differencesHealth status domainsInternational prospective studyPoor health statusHealth status measuresMultivariable linear regressionLower PAQ scoresBaseline characteristicsClinical characteristicsPAD symptomsTreatment satisfactionArterial diseaseProspective studyFemale sex
2009
Preoperative Cardiac Risk Index Predicts Long-term Mortality and Health Status
Hoeks SE, Reimer W, van Gestel YR, Smolderen KG, Verhagen H, van Domburg RT, van Urk H, Poldermans D. Preoperative Cardiac Risk Index Predicts Long-term Mortality and Health Status. The American Journal Of Medicine 2009, 122: 559-565. PMID: 19376487, DOI: 10.1016/j.amjmed.2008.10.041.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiovascular DiseasesCerebrovascular DisordersConfidence IntervalsData CollectionDiabetes Mellitus, Type 1FemaleFollow-Up StudiesHealth StatusHealth SurveysHumansMaleMiddle AgedNetherlandsOdds RatioPerioperative CarePeripheral Vascular DiseasesPredictive Value of TestsPreoperative CarePrognosisRegression AnalysisRenal InsufficiencyRisk AdjustmentRisk AssessmentRisk FactorsSurveys and QuestionnairesSurvival AnalysisVascular Surgical ProceduresConceptsPeripheral Artery QuestionnaireImpaired health statusPeripheral arterial disease patientsArterial disease patientsInsulin-dependent diabetesLate mortalityPrognostic factorsHealth statusVascular surgeryRenal insufficiencyCerebrovascular diseaseDisease patientsDisease-specific Peripheral Artery QuestionnaireLong-term health statusPAQ summary scorePerioperative cardiac riskCardiac risk factorsCardiac Risk IndexLong-term mortalityPeripheral arterial diseaseImportant prognostic factorIndependent prognostic factorIschemic heart diseaseMultivariable regression analysisRisk index score
2008
Clinical validity of a disease-specific health status questionnaire: The Peripheral Artery Questionnaire
Hoeks SE, Smolderen KG, Reimer W, Verhagen HJ, Spertus JA, Poldermans D. Clinical validity of a disease-specific health status questionnaire: The Peripheral Artery Questionnaire. Journal Of Vascular Surgery 2008, 49: 371-377. PMID: 19028064, DOI: 10.1016/j.jvs.2008.08.089.Peer-Reviewed Original ResearchMeSH KeywordsAgedDisability EvaluationFactor Analysis, StatisticalFemaleHealth Status IndicatorsHumansIntermittent ClaudicationMaleNetherlandsPain MeasurementPatient SatisfactionPeripheral Arterial DiseasePredictive Value of TestsPsychometricsRecovery of FunctionReproducibility of ResultsRetrospective StudiesSensitivity and SpecificitySeverity of Illness IndexSurveys and QuestionnairesTreatment OutcomeVascular Surgical ProceduresWalkingConceptsPeripheral Artery QuestionnairePeripheral arterial diseaseDisease-specific Peripheral Artery QuestionnaireClear dose-response relationPAQ summary scoreDose-response relationClinical indicesClinical validitySummary scoresPAD patientsEQ-VASEQ-5DHealth statusLee Cardiac Risk IndexSymptomatic peripheral arterial diseaseEuroQol visual analogue scaleBaseline clinical indicesConsecutive PAD patientsGeneric EQ-5DSeverity of claudicationCardiac Risk IndexDisease-specific health status questionnaireEQ-5D indexHealth Status QuestionnairePatient-centered outcomesFurther Validation of the Peripheral Artery Questionnaire: Results from a Peripheral Vascular Surgery Survey in the Netherlands
Smolderen K, Hoeks S, Aquarius A, Reimer W, Spertus J, van Urk H, Denollet J, Poldermans D. Further Validation of the Peripheral Artery Questionnaire: Results from a Peripheral Vascular Surgery Survey in the Netherlands. Journal Of Vascular Surgery 2008, 48: 1355. DOI: 10.1016/j.jvs.2008.09.034.Peer-Reviewed Original ResearchPeripheral Artery QuestionnaireFurther Validation of the Peripheral Artery Questionnaire: Results from a Peripheral Vascular Surgery Survey in the Netherlands
Smolderen KG, Hoeks SE, Aquarius AE, Reimer W, Spertus JA, van Urk H, Denollet J, Poldermans D. Further Validation of the Peripheral Artery Questionnaire: Results from a Peripheral Vascular Surgery Survey in the Netherlands. European Journal Of Vascular And Endovascular Surgery 2008, 36: 582-591. PMID: 18804390, DOI: 10.1016/j.ejvs.2008.07.015.Peer-Reviewed Original ResearchMeSH KeywordsAgedCross-Sectional StudiesDisability EvaluationFemaleHealth Care SurveysHealth Status IndicatorsHumansLanguageMaleMiddle AgedNetherlandsPatient SatisfactionPerceptionPeripheral Vascular DiseasesPrincipal Component AnalysisQuality of LifeRecovery of FunctionReproducibility of ResultsSurveys and QuestionnairesTreatment OutcomeVascular Surgical ProceduresConceptsPeripheral Artery QuestionnairePeripheral arterial diseaseEQ-5D scalePAD patientsPatients' health statusHealth statusPerceived DisabilityTreatment satisfactionPhysical functionEuro Heart Survey ProgrammeDisease-specific health statusAdverse cardiovascular eventsCross-sectional studyCardiovascular eventsArterial diseaseTreatment optionsPatientsAlpha valuesClinical researchCronbach's alpha valuesDutch versionConvergent validityDisabilityStatusQuestionnaire