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Zachary Levine, PhD

Assistant Professor of Pathology and Molecular Biophysics and Biochemistry



Zachary Levine is currently an Assistant Professor of Pathology and of Molecular Biophysics & Biochemistry at the Yale School of Medicine and the Graduate School at Yale University. While trained in computational biophysics with special emphasis in protein folding, his interests have recently expanded into solution biophysics measurements of soluble amyloid oligomers. Many of his projects combine atomistic molecular dynamics (MD) simulations with single-molecule fluorescence techniques (smFRET, FCS, and anisotropy) in order to deduce the physical and thermodynamic determinants of age-related diseases.

In particular, his lab seeks to understand protein aggregation diseases from a biophysical perspective. Many of these conditions involve a toxic accumulation of amyloid proteins and plaques over the lifecourse, leading to degenerative dysfunction and death. By combining molecular models of protein folding and aggregation with solution biophysics techniques, the Levine lab structurally and functionally characterizes amyloid oligomers that are distinctly pathological in order to mitigate degenerative diseases and age-related processes.

Education & Training

  • Postdoctoral Training
    University of California Santa Barbara (2017)
  • PhD
    University of Southern California, Physics (2013)
  • MSc
    University of Southern California, Computer Science (2012)
  • MA
    University of Southern California, Physics (2008)
  • BS
    San Francisco State University, Physics (2006)

Professional Service

Biophysical Society - Intrinsically Disordered Protein SubgroupCo-Chair2019 - 2020

Departments & Organizations