Youngseob Jung
Associate Research ScientistAbout
Research
Publications
2023
Reduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration
Tejwani L, Jung Y, Kokubu H, Sowmithra S, Ni L, Lee C, Sanders B, Lee P, Xiang Y, Luttik K, Soriano A, Yoon J, Park J, Ro H, Ju H, Liao C, Tieze S, Rigo F, Jafar-Nejad P, Lim J. Reduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration. Journal Of Clinical Investigation 2023, 133: e138207. PMID: 37384409, PMCID: PMC10425213, DOI: 10.1172/jci138207.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisTDP-43-related neurodegenerationNeurodegenerative disordersTransactive response DNA-binding protein 43Sporadic amyotrophic lateral sclerosisDNA-binding protein 43Subset of patientsTDP-43 speciesTDP-43 inclusionsDistinct mouse modelsTDP-43 proteinopathyFamilial amyotrophic lateral sclerosisNemo-like kinaseMultiple neurodegenerative disordersAutophagy/lysosome pathwayTDP-43-positive aggregatesALS patientsALS casesSporadic ALSPharmacological reductionProtein 43Lateral sclerosisMouse modelParkinson's diseaseTDP-43
2022
Discrimination of Invasive Human Skin Tumor Using an Ultrafast ATP–Proton AND-Gate Probe
Jun Y, Kim K, Yang Y, Jung Y, Kim K, Kim H, Oh B, Ahn K. Discrimination of Invasive Human Skin Tumor Using an Ultrafast ATP–Proton AND-Gate Probe. ACS Sensors 2022, 7: 1068-1074. PMID: 35353484, DOI: 10.1021/acssensors.1c02712.Peer-Reviewed Original ResearchConceptsCell carcinomaSquamous cell carcinomaBasal cell carcinomaHuman skin tumorsRecurrence of cancerCell cycleInvasive areasUnscheduled proliferationAcidic environment of tumorEnvironment of tumorsDetection of ATPCancer cellsSkin tumorsTumorTwo-photon microscopyCarcinomaMolecular probesCancerFluorescent probeCellsProbe
2021
Microglia regulate brain Progranulin levels through the endocytosis-lysosomal pathway
Dong T, Tejwani L, Jung Y, Kokubu H, Luttik K, Driessen TM, Lim J. Microglia regulate brain Progranulin levels through the endocytosis-lysosomal pathway. JCI Insight 2021, 6: e136147. PMID: 34618685, PMCID: PMC8663778, DOI: 10.1172/jci.insight.136147.Peer-Reviewed Original ResearchConceptsPGRN levelsNovel potential therapeutic targetFrontotemporal lobar degenerationPotential therapeutic targetNeuronal ceroid lipofuscinosisPGRN deficiencyPGRN expressionLysosomal pathwayProgranulin levelsPathological changesHaploinsufficient miceTherapeutic targetMicrogliaNeuropathological phenotypeAlzheimer's diseaseProgranulinCeroid lipofuscinosisGlycoprotein progranulinNeurodegenerative diseasesDiseaseMiceGenetic alterationsNemo-like kinaseGenetic interaction studiesGenetic variantsHNRNP A1 Promotes Lung Cancer Cell Proliferation by Modulating VRK1 Translation
Ryu H, Jung Y, Lee N, Seo J, Kim S, Lee K, Kim D, Kim K. HNRNP A1 Promotes Lung Cancer Cell Proliferation by Modulating VRK1 Translation. International Journal Of Molecular Sciences 2021, 22: 5506. PMID: 34071140, PMCID: PMC8197126, DOI: 10.3390/ijms22115506.Peer-Reviewed Original ResearchMeSH Keywords3' Untranslated RegionsBase SequenceCell CycleCell LineCRISPR-Cas SystemsCyclin D1Eukaryotic Initiation Factor-3Gene Expression Regulation, NeoplasticGenes, ReporterHeterogeneous Nuclear Ribonucleoprotein A1HumansIntracellular Signaling Peptides and ProteinsLung NeoplasmsNeoplasm ProteinsProtein BindingProtein BiosynthesisProtein DomainsProtein Interaction MappingProtein Serine-Threonine KinasesRecombinant ProteinsRNA InterferenceRNA, MessengerSequence DeletionUp-RegulationConceptsVaccinia-related kinase 1HnRNP A1Post-transcriptional regulationLung cancer cell proliferationCAMP response element-binding proteinCancer cell proliferationHnRNP protein familyHnRNP A1 bindingCyclin D1Cell proliferationResponse element-binding proteinElement-binding proteinDevelopment of neurodegenerative diseasesOverall survivalVRK1 expressionProtein familyNuclear ribonucleoproteinLung cancerHnRNPOverall survival of patientsA1 bindingLung cancer tissuesKinase 1HnRNP A1 expressionSurvival of patients
2020
BDNF-induced local translation of GluA1 is regulated by HNRNP A2/B1
Jung Y, Seo J, Ryu H, Kim D, Lee K, Kim K. BDNF-induced local translation of GluA1 is regulated by HNRNP A2/B1. Science Advances 2020, 6: eabd2163. PMID: 33219033, PMCID: PMC7679154, DOI: 10.1126/sciadv.abd2163.Peer-Reviewed Original ResearchHeterogeneous nuclear ribonucleoproteinInduction of synaptic plasticityAMPA receptor subunit GluA1Internal ribosome entry siteAMPA receptor expressionDendritic spine densityHnRNP A2/B1GluA1 expressionReceptor expressionAMPA receptorsSubunit GluA1Molecular mechanismsHeterogeneous nuclear ribonucleoprotein A2/B1Spine densitySynaptic plasticityRegulatory mechanismsCap-independent mannerIRES-mediated translationRibosome entry siteLocal expressionGluA1AMPADendritic mRNAsUp-regulatedSynaptic mRNAs
2019
The RNA-binding protein hnRNP Q represses translation of the clock gene Bmal1 in murine cells
Jung Y, Ryu H, Kim S, Lee K, Gu S, Yi H, Ku H, Jang S, Kim K. The RNA-binding protein hnRNP Q represses translation of the clock gene Bmal1 in murine cells. Journal Of Biological Chemistry 2019, 294: 7682-7691. PMID: 30948510, PMCID: PMC6514626, DOI: 10.1074/jbc.ra118.006947.Peer-Reviewed Original ResearchDAP5 increases axonal outgrowth of hippocampal neurons by enhancing the cap-independent translation of DSCR1.4 mRNA
Seo J, Jung Y, Kim D, Ryu H, Lee J, Kim S, Kim K. DAP5 increases axonal outgrowth of hippocampal neurons by enhancing the cap-independent translation of DSCR1.4 mRNA. Cell Death & Disease 2019, 10: 49. PMID: 30718468, PMCID: PMC6362140, DOI: 10.1038/s41419-018-1299-x.Peer-Reviewed Original ResearchUpf1 regulates neurite outgrowth and branching by transcriptional and post-transcriptional modulation of Arc
Ryu H, Seo J, Jung Y, Kim S, Kim E, Jang S, Kim K. Upf1 regulates neurite outgrowth and branching by transcriptional and post-transcriptional modulation of Arc. Journal Of Cell Science 2019, 132: jcs.224055. PMID: 30584064, DOI: 10.1242/jcs.224055.Peer-Reviewed Original Research
2016
HnRNP Q Has a Suppressive Role in the Translation of Mouse Cryptochrome1
Lim I, Jung Y, Kim D, Kim K. HnRNP Q Has a Suppressive Role in the Translation of Mouse Cryptochrome1. PLOS ONE 2016, 11: e0159018. PMID: 27392095, PMCID: PMC4938544, DOI: 10.1371/journal.pone.0159018.Peer-Reviewed Original ResearchNanowires: Quantitative Probing of Cu2+ Ions Naturally Present in Single Living Cells (Adv. Mater. 21/2016)
Lee J, Lee H, Pyo J, Jung Y, Seo J, Ryu H, Kim K, Je J. Nanowires: Quantitative Probing of Cu2+ Ions Naturally Present in Single Living Cells (Adv. Mater. 21/2016). Advanced Materials 2016, 28: 3978-3978. PMID: 27246918, DOI: 10.1002/adma.201670142.Peer-Reviewed Original Research