Young-Ri Shim
Postdoctoral AssociateAbout
Research
Publications
2025
Binge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells
Yang K, Kim K, Ryu T, Shim Y, Kim H, Choi S, Kim M, Chung K, Lee E, Lee K, Jeon J, Kim P, Kim Y, Ku T, Jeong H, Nam K, Lim G, Choi D, Kim S, Eun H, Kim W, Jeong W. Binge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells. Nature Communications 2025, 16: 5546. PMID: 40595616, PMCID: PMC12216207, DOI: 10.1038/s41467-025-60820-3.Peer-Reviewed Original ResearchConceptsVesicular glutamate transporter 3Alcohol-related steatohepatitisKupffer cellsIntracellular Ca2+ levelsMetabotropic glutamate receptor 5Chronic alcohol intakeBinge drinkingImmune cell activationGlutamate receptor 5Analysis of patient samplesCa2+ levelsHepatic amino acid metabolismNADPH oxidase 2Plasma glutamate concentrationExocytosis of glutamateAlcohol intakeReceptor 5Male miceAryl hydrocarbon receptorAmino acid metabolismHepatic inflammationCell activationPerivenous hepatocytesGlutamate secretionPatient samples
2024
A non-catalytic role of IPMK is required for PLCγ1 activation in T cell receptor signaling by stabilizing the PLCγ1-Sam68 complex
Hong S, Kim K, Shim Y, Park J, Choi S, Min H, Lee S, Song J, Kang S, Jeong W, Seong R, Kim S. A non-catalytic role of IPMK is required for PLCγ1 activation in T cell receptor signaling by stabilizing the PLCγ1-Sam68 complex. Cell Communication And Signaling 2024, 22: 526. PMID: 39478550, PMCID: PMC11524019, DOI: 10.1186/s12964-024-01907-0.Peer-Reviewed Original ResearchConceptsInositol polyphosphate multikinaseT cell receptor signalingSrc family kinasesT cell receptorYeast two-hybrid screenFunctional protein-protein interactionsSrc-associated substrateTwo-hybrid screenNon-catalytic roleCD4+ T cellsProtein-protein interactionsPhosphatidylinositol 4,5-bisphosphateGrowth factor signalingC gamma 1Dominant-negative peptideNon-catalytic activitiesDownstream Signaling PathwaysQuantitative real-time PCRStimulation of T cell receptorSubstrate specificityPleiotropic enzymeProtein complexesFamily kinasesCo-ImmunoprecipitationT cellsCX3CR1+ macrophages interact with HSCs to promote HCC through CD8+ T-cell suppression
Jeong J, Choi S, Shim Y, Kim H, Lee Y, Yang K, Kim K, Kim M, Chung K, Kim S, Byun J, Eun H, Jeong W. CX3CR1+ macrophages interact with HSCs to promote HCC through CD8+ T-cell suppression. Hepatology 2024, 82: 655-668. PMID: 40833997, PMCID: PMC12356560, DOI: 10.1097/hep.0000000000001021.Peer-Reviewed Original ResearchConceptsCD8+ T cellsArginase-1 expressionIn vitro cocultureArginase-1Peritumoral areaMyeloid cellsImmunoregulatory functionsCD8+ T cell suppressionCD8+ T cell proliferationPharmacological inhibitionColocalized expressionGenetic deficiencyHuman LX-2 cellsT cell suppressionTumor-bearing miceT cell proliferationCD14+ cellsCX3CL1 mRNA expressionSubpopulation of macrophagesDirect treatmentExpression of CX3CL1Function of HSCsHepatic stellate cellsAdoptive transferFlow cytometry analysis
2023
xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity
Kim H, Shim Y, Kim H, Yang K, Ryu T, Kim K, Choi S, Kim M, Woo C, Chung K, Hong S, Shin H, Suh J, Jung Y, Hwang G, Kim W, Kim S, Eun H, Seong J, Jeong W. xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity. Cell Reports 2023, 42: 112636. PMID: 37310859, DOI: 10.1016/j.celrep.2023.112636.Peer-Reviewed Original ResearchConceptsIFN-g productionObesity-related metabolic disordersNK cellsIFN-gNatural killer (NK) cellsMetabolic disordersMetabotropic glutamate receptor 5NK cell recruitmentNatural killer cellsInterferon-g productionC-X-C motif chemokine ligandGlutamate receptor 5Effect of obesityC-X-CMotif chemokine ligandKiller cellsGlutamate excretionBidirectional pathwaysCXCL12/CXCR4 axisWhite adipose tissueCXCL12 expressionReceptor 5Cell recruitmentInflammatory activityChemokine ligandComprehensive transcriptomic analysis and meta-analysis identify therapeutic effects of N-acetylcysteine in nonalcoholic fatty liver disease
Yang K, Kim H, Shim Y, Ryu T, Kim C. Comprehensive transcriptomic analysis and meta-analysis identify therapeutic effects of N-acetylcysteine in nonalcoholic fatty liver disease. Frontiers In Pharmacology 2023, 14: 1186582. PMID: 37256235, PMCID: PMC10225598, DOI: 10.3389/fphar.2023.1186582.Peer-Reviewed Original ResearchNonalcoholic fatty liver diseaseEffect of N-acetylcysteineN-acetylcysteineFatty liver diseaseLiver diseaseEfficacy of N-acetylcysteineProtective effect of N-acetylcysteineTherapeutic potentialPrevalence of nonalcoholic fatty liver diseaseTherapeutic effect of N-acetylcysteineMeta-analysisLevels compared to controlsN-acetylcysteine treatmentAssociated with NAFLD developmentSystematic Review CentrePreclinical studiesClinical trialsLiver injuryWeb of ScienceGlucose intoleranceTherapeutic effectGlobal health issueCochrane LibraryEgger's testHepatic steatosisExosome-Based Delivery of Super-Repressor IκBα Alleviates Alcohol-Associated Liver Injury in Mice
Kim H, Shim Y, Choi S, Falana T, Yoo J, Ahn S, Park M, Seo H, Choi C, Jeong W. Exosome-Based Delivery of Super-Repressor IκBα Alleviates Alcohol-Associated Liver Injury in Mice. Pharmaceutics 2023, 15: 636. PMID: 36839957, PMCID: PMC9965399, DOI: 10.3390/pharmaceutics15020636.Peer-Reviewed Original ResearchAlcohol-associated liver injuryAlcohol-associated liver diseaseInflammatory gene expression levelsInfiltration of neutrophilsKupffer cellsLiver injuryModulation of NF-kB activationActivation of Kupffer cellsGene expression levelsExpression levelsAlcohol binge drinkingNuclear translocation of NF-kBGut-derived lipopolysaccharideHepatic stellate cellsTranslocation of NF-kBNuclear factor-KBNF-kB activationEfficient therapeutic approachApoptosis of hepatocytesIntravenous injectionLiver diseaseTherapeutic approachesExosome technologyInflammatory responseStellate cellsThe Efficacy of Panax ginseng for the Treatment of Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Preclinical Studies
Yang K, Kim H, Shim Y, Song M. The Efficacy of Panax ginseng for the Treatment of Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Preclinical Studies. Nutrients 2023, 15: 721. PMID: 36771427, PMCID: PMC9919883, DOI: 10.3390/nu15030721.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseStandardized mean differenceFatty liver diseasePreclinical studiesLiver diseaseMeta-analysis of preclinical studiesCochrane Library databasesLevels of alanine aminotransferaseProtective effectProtective effects of natural compoundsHigh-density lipoproteinRandom-effects modelRisk of bias toolSystematic Review Center for Laboratory Animal ExperimentationTreatment of nonalcoholic fatty liver diseaseFasting GlucoseLibrary databasesTotal cholesterolWeb of ScienceAnimal modelsEffects of natural compoundsLaboratory Animal ExperimentationMean differenceAlanine aminotransferaseEgger's testCatecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease
Kim H, Shim Y, Choi S, Kim M, Lee G, You H, Choi W, Yang K, Ryu T, Kim K, Kim M, Woo C, Chung K, Hong S, Eun H, Kim S, Ko G, Park J, Gao B, Kim W, Jeong W. Catecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease. Experimental & Molecular Medicine 2023, 55: 158-170. PMID: 36631664, PMCID: PMC9898237, DOI: 10.1038/s12276-022-00921-x.Peer-Reviewed Original ResearchConceptsAlcohol-associated liver diseaseApoptotic Kupffer cellsKupffer cellsSingle-cell RNA sequencingCatecholamine levelsLiver diseaseKupffer cell apoptosisPortal bloodGrowth differentiation factor 15Chronic ethanol intakePathogen challengeChronic alcohol exposureApoptotic genesChronic alcohol consumptionB2 adrenergic receptorDifferentiation factor 15Effects of catecholaminesEthanol-fed miceExpression of ADRB2KC apoptosisChronic ethanol-fed miceGrowth differentiation factorRegulatory roleCell apoptosisGenetic ablation
2021
Metabotropic Glutamate Receptor 5 in Natural Killer Cells Attenuates Liver Fibrosis by Exerting Cytotoxicity to Activated Stellate Cells
Choi W, Ryu T, Lee J, Shim Y, Kim M, Kim H, Kim Y, Yang K, Kim K, Choi S, Kim W, Kim S, Eun H, Jeong W. Metabotropic Glutamate Receptor 5 in Natural Killer Cells Attenuates Liver Fibrosis by Exerting Cytotoxicity to Activated Stellate Cells. Hepatology 2021, 74: 2170-2185. PMID: 33932306, DOI: 10.1002/hep.31875.Peer-Reviewed Original ResearchConceptsNK cell cytotoxicityProduction of IFN-gMGluR5 knockout miceMetabotropic glutamate receptor 5Activation of mGluR5NK cellsGlutamate receptor 5Liver fibrosisIFN-gCell cytotoxicityIn vitro activityNatural killerMGluR5 activationKnockout miceReceptor 5Frequency of NK cellsCytotoxicity of NK cellsReduced stimulationAdvanced liver fibrosisNatural killer cellsStimulation of mGluR5Wild-type miceLiver fibrosis regressionActivated stellate cellsInjection of carbon tetrachloride
2020
Mitochondrial Double‐Stranded RNA in Exosome Promotes Interleukin‐17 Production Through Toll‐Like Receptor 3 in Alcohol‐associated Liver Injury
Lee J, Shim Y, Seo W, Kim M, Choi W, Kim H, Kim Y, Yang K, Ryu T, Jeong J, Choi H, Eun H, Kim S, Mun H, Yoon J, Jeong W. Mitochondrial Double‐Stranded RNA in Exosome Promotes Interleukin‐17 Production Through Toll‐Like Receptor 3 in Alcohol‐associated Liver Injury. Hepatology 2020, 72: 609-625. PMID: 31849082, PMCID: PMC7297661, DOI: 10.1002/hep.31041.Peer-Reviewed Original ResearchConceptsAlcohol-associated liver diseaseToll-like receptor 3IL-17A productionCD4+ T cellsT cellsIL-17AWT miceHepatocytes of WT miceKupffer cellsIL-1B expressionDouble-stranded RNAMitochondrial double-stranded RNAStages of alcohol-associated liver diseaseAlcohol-associated liver injuryProduction of IL-17AReceptor 3MRNA expressionToll-like receptor 3 knockoutWild-type (WT) miceToll-like receptor 3 activationInterleukin-17 productionIL-17A expressionInterleukin (IL)-17AExpression of mitochondrial genesSmall-sized RNA
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Internal Medicine
Department of Digestive Diseases, 300 Cedar Street, S220
New Haven, Connecticut 06519
United States
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The Anlyan Center
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300 Cedar Street, Fl 2nd, Rm S220
New Haven, CT 06519