2024
Identifying neurofunctional domains across substance use disorders
Hartwell E, Schwandt M, Nunez Y, Wetherill R, Kember R, Wiers C, Gelernter J, Kranzler H. Identifying neurofunctional domains across substance use disorders. The American Journal Of Drug And Alcohol Abuse 2024, ahead-of-print: 1-11. PMID: 39018668, DOI: 10.1080/00952990.2024.2368180.Peer-Reviewed Original ResearchSubstance use disordersHistory of abuse/neglectExploratory factor analysisExecutive functionSubstance useSemi-Structured Assessment for Drug DependenceWisconsin Card Sorting TestPersistence of substance use disordersNEO Personality InventoryCard Sorting TestFactor analysisNature of substance use disordersSix-factor modelPatterns of associationPersonality InventoryNeurofunctional domainsSorting TestDrug dependenceTargeted clinical interventionsLatent variable modelsClinical interventionsFit indicesAbuse/neglectDisordersLatent domains
2023
Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder
Stiltner B, Pietrzak R, Tylee D, Nunez Y, Adhikari K, Kranzler H, Gelernter J, Polimanti R. Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder. IScience 2023, 26: 107336. PMID: 37554454, PMCID: PMC10405253, DOI: 10.1016/j.isci.2023.107336.Peer-Reviewed Original ResearchCocaine use disorderUse disordersAddiction patternsMixed bipolar episodesLatent class analysisDSM-5 diagnosisPosttraumatic stress disorderAntisocial personality disorderPsA severityMedication useHigher PSAPSA subgroupsHigher oddsBipolar episodesStress disorderPersonality disorderDisordersSubgroupsAgeSexClass analysisParticipantsComorbiditiesDiseaseDiagnosis
2022
Genome-wide meta-analysis of alcohol use disorder in East Asians
Zhou H, Kalayasiri R, Sun Y, Nuñez YZ, Deng HW, Chen XD, Justice AC, Kranzler HR, Chang S, Lu L, Shi J, Sanichwankul K, Mutirangura A, Malison RT, Gelernter J. Genome-wide meta-analysis of alcohol use disorder in East Asians. Neuropsychopharmacology 2022, 47: 1791-1797. PMID: 35094024, PMCID: PMC9372033, DOI: 10.1038/s41386-022-01265-w.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAlcohol dependenceUse disordersICD-9-CM diagnosisGenome-wide association studiesEast Asian subjectsElectronic health recordsPack yearsLeading causePolygenic risk scoresThai cohortRisk scoreAlcohol consumptionDSM-IVAsian subjectsCohortMillion Veteran Program sampleHealth recordsLarge genome-wide association studiesEast AsiansOngoing recruitmentRisk genesDisordersRisk lociSubjects