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PET Engineer
Research
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Tim Mulnix's published research.
David Matuskey, MD
Richard Carson, PhD
Takuya Toyonaga, MD, PhD
Shannan Henry
Tommaso Volpi
Ansel Hillmer, PhD
Publications
2025
Development and Initial Evaluation of 3D-Printed High Resolution Brain Phantom for PET
Lo C, Shanina E, Gravel P, Hu Y, Lucero S, Martins S, Mulnix T, Fontaine K, Nejati S, Sun X, Li H, Qi J, Cherry S, Carson R, Toyonaga T. Development and Initial Evaluation of 3D-Printed High Resolution Brain Phantom for PET. IEEE Transactions On Radiation And Plasma Medical Sciences 2025, PP: 1-1. PMID: 41446501, PMCID: PMC12724537, DOI: 10.1109/trpms.2025.3638588.Peer-Reviewed Original ResearchConceptsPET systemPET system performanceBrain PET systemHigh-resolution PET systemsSpatial resolutionSuperior spatial resolutionBrain phantomPhantom typesPhantom preparationPhantomReconstruction parametersRepositioning accuracyContrast modulationHuman brain anatomyReconstructed imagesMode dataContrast ratioImage resolutionHigh-resolution 3D printingResolutionAnatomical fidelityWhite matterGray matterModeFidelityExceptional brain PET images from the NeuroEXPLORER: scans with targeted radiopharmaceuticals and comparison to HRRT
Volpi T, Toyonaga T, Khattar N, Gallezot J, Naganawa M, Vanderlinden G, Honhar P, Zeng T, Fontaine K, Mulnix T, Hu L, Sun X, Henry S, Matuskey D, Radhakrishnan R, Guo L, Hu Y, Zhang J, Zheng X, Nabulsi N, Huang Y, Badawi R, Cherry S, Hillmer A, Jones T, Liu C, Morris E, Qi J, Li H, Carson R. Exceptional brain PET images from the NeuroEXPLORER: scans with targeted radiopharmaceuticals and comparison to HRRT. European Journal Of Nuclear Medicine And Molecular Imaging 2025, 1-12. PMID: 41177836, DOI: 10.1007/s00259-025-07605-4.Peer-Reviewed Original ResearchCitationsAltmetricConceptsStandardized uptake valueTargeted radiopharmaceuticalsDopamine systemMultiple cortical areasSerotonin transporterRaphe nucleusMeasurement of tracer uptakeBrain regionsBrain structuresSubcortical nucleiPositron emission tomographyCortical areasSynaptic densityPET researchFocal uptakePaired scansUptake valueTracer uptakePET systemGray matterEarly imagesEmission tomographyHealthy individualsTracer deliveryNeuroExplorerCarotid Artery Image-Derived Blood Time-Activity Curves on the NeuroEXPLORER: Initial Multitracer Validation Against Arterial Sampling.
Volpi T, Gallezot J, Henry S, Dias M, Khattar N, Toyonaga T, Fontaine K, Mulnix T, Zhang J, Guo L, Gravel P, Radhakrishnan R, Hillmer A, Matuskey D, Carson R. Carotid Artery Image-Derived Blood Time-Activity Curves on the NeuroEXPLORER: Initial Multitracer Validation Against Arterial Sampling. Journal Of Nuclear Medicine 2025, 66: 1993-2001. PMID: 41043999, PMCID: PMC12676648, DOI: 10.2967/jnumed.125.270414.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsArea under the curveCommon carotidTime-activity curvesLate area under the curveMethods:Carotid arteryRegions-of-interestResults:Blood samplesPartial volume effectsImage-derived input functionArterial blood samplesArterial input functionAlternative to arterial blood samplingBlood time-activity curvesPET kinetic modelingGold standardInput functionBackground activityArterial samplesCarotidBrain-dedicated PET scannersBrain PET
2024
Quantitative Accuracy Assessment of the NeuroEXPLORER for Diverse Imaging Applications: Moving Beyond Standard Evaluations.
Omidvari N, Shanina E, Leung E, Sun X, Li Y, Mulnix T, Gravel P, Henry S, Matuskey D, Volpi T, Jones T, Badawi R, Li H, Carson R, Qi J, Cherry S. Quantitative Accuracy Assessment of the NeuroEXPLORER for Diverse Imaging Applications: Moving Beyond Standard Evaluations. Journal Of Nuclear Medicine 2024, 66: 150-157. PMID: 39638433, PMCID: PMC11705792, DOI: 10.2967/jnumed.124.268309.Peer-Reviewed Original ResearchCitationsConceptsContrast recovery coefficientHoffman phantomUniform phantomIQ phantomRecovery coefficientBrain PET systemHoffman brain phantomBrain uptakeSpatial resolutionDiverse imaging applicationsCylindrical phantomPET systemBrain phantomNeuroimaging studiesImage qualityImaging conditionsPhantomReconstruction parametersImaging time pointsTime pointsImage-derived input functionHigher spatial resolutionQuantitative accuracyDelayed time pointsBrain disordersPerformance Characteristics of the NeuroEXPLORER, a Next-Generation Human Brain PET/CT Imager
Li H, Badawi R, Cherry S, Fontaine K, He L, Henry S, Hillmer A, Hu L, Khattar N, Leung E, Li T, Li Y, Liu C, Liu P, Lu Z, Majewski S, Matuskey D, Morris E, Mulnix T, Omidvari N, Samanta S, Selfridge A, Sun X, Toyonaga T, Volpi T, Zeng T, Jones T, Qi J, Carson R. Performance Characteristics of the NeuroEXPLORER, a Next-Generation Human Brain PET/CT Imager. Journal Of Nuclear Medicine 2024, 65: jnumed.124.267767. PMID: 38871391, PMCID: PMC11294061, DOI: 10.2967/jnumed.124.267767.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPeak noise-equivalent count rateNoise-equivalent count rateTime-of-flight resolutionField of viewCount rateExtended axial field-of-viewTransverse field-of-viewAxial field-of-viewField-of-view centerMini-Derenzo phantomSpatial resolutionTangential spatial resolutionsCount rate performanceContrast recovery coefficientHuman brain PET imagingMeasurements of spatial resolutionNEMA sensitivityEnergy resolutionScatter fractionBrain phantomBackprojection reconstructionBrain PET imagingTime resolutionRadial offsetF-FDG imagingRelationship between neuroimaging and cognition in frontotemporal dementia: An FDG‐PET and structural MRI study
Cayir S, Volpi T, Toyonaga T, Gallezot J, Yang Y, Sadabad F, Mulnix T, Mecca A, Fesharaki‐Zadeh A, Matuskey D. Relationship between neuroimaging and cognition in frontotemporal dementia: An FDG‐PET and structural MRI study. Journal Of Neuroimaging 2024, 34: 627-634. PMID: 38676301, PMCID: PMC11511789, DOI: 10.1111/jon.13206.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMoCA scoresFDG-PETAssociation of cognitionStandardized uptake value ratioMontreal Cognitive AssessmentSignificant positive associationFrontotemporal dementiaPrimary outcome measurePosterior cingulate cortexDecline of cognitive functionYears of ageGM volumeFrontal cortexOutcome measuresCognitive dysfunctionGray matterCognitive AssessmentMoCAAssociated with cognitive dysfunctionFluorodeoxyglucose (FDG)-PETPositive associationMagnetic resonance imagingPartial volume correctionCognitive functionDementia
2022
Event-by-Event 3D Continuous Motion Correction Based on a Data-Driven Motion Estimation Algorithm for 82Rb Myocardial Perfusion Imaging
Tsai Y, Fontaine K, Mulnix T, Armstrong I, Hayden C, Spottiswoode B, Casey M, Liu C. Event-by-Event 3D Continuous Motion Correction Based on a Data-Driven Motion Estimation Algorithm for 82Rb Myocardial Perfusion Imaging. 2022, 00: 1-4. DOI: 10.1109/nss/mic44845.2022.10399100.Peer-Reviewed Original ResearchConceptsMotion correctionData-driven motion estimationPET/CT scannerSuperior-inferior motionMotion effectsSilicon photomultipliersNEMA phantomReconstruction frameworkPET acquisitionReconstructed image qualityCardiac PETMotion estimation algorithmPatient datasetsImage qualityMyocardial perfusion imagingCorrectionMotion monitoringTemporal resolutionSiPMMotionPhotomultiplierMotion estimationMotion vectorsPhantomCorrection algorithm
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