Skip to Main Content
Biological & Biomedical Sciences
Yale Home

INFORMATION FOR

    Thuy Tran, MD, PhD

    Assistant Professor of Medicine (Medical Oncology)
    DownloadHi-Res Photo

    Are You a Patient?

    View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.

    View Doctor Profile

    About

    Titles

    Assistant Professor of Medicine (Medical Oncology)

    Biography

    Dr. Tran is an Assistant Professor of Medicine (Medical Oncology) and cares for patients with melanoma and other advanced skin cancers at the Smilow Cancer Hospital in New Haven and in Smilow Guilford. She participated in the ABIM Physician-Scientist Research Pathway and completed both her internal medicine residency and hematology/oncology clinical fellowship at Yale.  She received her MD and PhD degrees from Vanderbilt University School of Medicine. 

    Dr. Tran is actively engaged in translational research in melanoma brain metastases and developing novel therapeutics and drug combinations to improve responses in melanoma and overcome immune resistance.  She has been funded through the Yale Cancer Center T32, the YCC K12 Calabresi Immuno-Oncology Training Program (IOTP), and the Skin Cancer SPORE career enhancement program.  Dr. Tran is the principal investigator of several clinical trials in melanoma.

    Appointments

    Other Departments & Organizations

    Education & Training

    Clinical Fellow
    Yale-New Haven Hospital (2019)
    Resident
    Yale-New Haven Hospital (2015)
    MD
    Vanderbilt University School of Medicine (2013)
    PhD
    Vanderbilt University School of Medicine, Department of Pathology, Microbiology, and Immunology (2011)
    BS
    Emory University, Biology and French (2005)

    Research

    Overview

    As a physician-scientist and clinical investigator, my hope is to be able to move bench research efficiency to the clinic. Most importantly, I want to learn from the patients and their experience to inform my studies. My ultimate goal is to improve immune treatment options and quality of life for patients with metastatic malignancies.

    My research focuses on understanding and improving clinical targets to overcome resistance to immune therapy.  We are actively engaged in studies related to macrophage migration inhibitor factor (MIF) in melanoma as well as understanding complications from brain metastatic disease.  I have focused on addressing neurologic complications of brain metastases or its treatment by (1) identifying mediators of metastasis-associated edema that can be given concurrently to further improve brain-active systemic therapies and patient outcomes, (2) identifying key immune cells driving radiation necrosis after treatment with stereotactic radiosurgery, and (3) determining key brain tumor infiltrating immune cell subsets and evaluating their effect on patient response and survival.  



    Medical Research Interests

    Blood-Brain Barrier; Clinical Trials as Topic; Drug Combinations; Immune Checkpoint Proteins; Melanoma; Neoplasm Metastasis

    Research at a Glance

    Yale Co-Authors

    Frequent collaborators of Thuy Tran's published research.

    Publications

    2024

    See All Publications

    Clinical Trials

    Current Trials

    Clinical Care

    Overview

    Clinical Specialties

    Melanoma and Onco-Dermatology; Medical Oncology

    Fact Sheets

    See All Fact Sheets On Yale Medicine

    Yale Medicine News

    See All News On Yale Medicine

    Are You a Patient?

    View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.

    View Doctor Profile

    Get In Touch

    Contacts

    Email
    Appointment Number

    Locations

    • Patient Care Locations

      Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.

      See Patient Care Locations