Lithium Reduces Impulsive Decision Making in Trans-diagnostic Patients at High Risk for Suicide Attempt Recurrence: A randomized, double blind, placebo-controlled, crossover study.
Murphy N, Pham G, Weyland A, Engelhardt J, Kypriotakis G, Thomas Y, Kosten T, Moukaddam N, Mathew S, Swann A. Lithium Reduces Impulsive Decision Making in Trans-diagnostic Patients at High Risk for Suicide Attempt Recurrence: A randomized, double blind, placebo-controlled, crossover study. Journal Of Affective Disorders Reports 2024, 100833. DOI: 10.1016/j.jadr.2024.100833.Peer-Reviewed Original ResearchImmediate memory taskInternal State ScaleTime perception tasksSuicidal behaviorImpulsive decisionsSuicide attemptsResponse latencySpectrum of suicidal behaviorsLethal suicidal behaviorMeasures of impulsivityLithium doseConservative response biasSevere suicide attemptsDouble-blind crossover designRandomized double-blind crossover designPrevent suicide riskEffects of lithiumPill placeboMemory taskBehavioral therapySuicide riskResponse biasAdjunctive behavioral therapySelf-harmAssociated with attempts