Thomas Kosten
Professor Adjunct, PsychiatryCards
About
Research
Publications
2024
Dexmedetomidine HCL (BXCL501) as a potential treatment for alcohol use disorder and comorbid PTSD: A phase 1b, placebo‐controlled crossover laboratory study
Petrakis I, Nolen T, Vandergrift N, Hirsch S, Krystal J, De Vivo M, Sabados J, Pisani E, Newcomb J, Kosten T. Dexmedetomidine HCL (BXCL501) as a potential treatment for alcohol use disorder and comorbid PTSD: A phase 1b, placebo‐controlled crossover laboratory study. American Journal On Addictions 2024 PMID: 39152094, DOI: 10.1111/ajad.13637.Peer-Reviewed Original ResearchPathophysiology of posttraumatic stress disorderAlcohol use disorderSubjective effects of alcoholEffects of alcoholUse disorderComorbid alcohol use disorderAlcohol cue reactivityPosttraumatic stress disorderCrossover laboratory studyCue reactivityAlcohol cravingNoradrenergic dysregulationStress disorderBlood pressureSubjective effectsEthanol administrationClinically significant adverse effectsPharmacotherapeutic approachesTest daysReceptor agonistsPotential treatmentDouble-blind fashionCravingDrinking alcoholDisordersLithium Reduces Impulsive Decision Making in Trans-diagnostic Patients at High Risk for Suicide Attempt Recurrence: A randomized, double blind, placebo-controlled, crossover study.
Murphy N, Pham G, Weyland A, Engelhardt J, Kypriotakis G, Thomas Y, Kosten T, Moukaddam N, Mathew S, Swann A. Lithium Reduces Impulsive Decision Making in Trans-diagnostic Patients at High Risk for Suicide Attempt Recurrence: A randomized, double blind, placebo-controlled, crossover study. Journal Of Affective Disorders Reports 2024, 100833. DOI: 10.1016/j.jadr.2024.100833.Peer-Reviewed Original ResearchImmediate memory taskInternal State ScaleTime perception tasksSuicidal behaviorImpulsive decisionsSuicide attemptsResponse latencySpectrum of suicidal behaviorsLethal suicidal behaviorMeasures of impulsivityLithium doseConservative response biasSevere suicide attemptsDouble-blind crossover designRandomized double-blind crossover designPrevent suicide riskEffects of lithiumPill placeboMemory taskBehavioral therapySuicide riskResponse biasAdjunctive behavioral therapySelf-harmAssociated with attemptsUse of Cigarettes and E-Cigarettes, Impulsivity, and Anxiety: Influences on Suicidal Ideation Among Youth and Young Adults in Texas
Wilkinson A, Chen B, Swann A, Graham D, Nielsen D, Kosten T, Loukas A, Mantey D, Bataineh B, Harrell M. Use of Cigarettes and E-Cigarettes, Impulsivity, and Anxiety: Influences on Suicidal Ideation Among Youth and Young Adults in Texas. Nicotine & Tobacco Research 2024, ntae163. PMID: 39028574, DOI: 10.1093/ntr/ntae163.Peer-Reviewed Original ResearchE-cigarette useCigarette useE-cigarettesRisk of suicidal ideationHigh riskCigarette/e-cigarette useTexas Adolescent TobaccoAssociated with higher riskYoung adultsUse of cigarettesSuicidal ideationMixed-effects logistic regressionIncreased risk of suicidal ideationIncreased riskHigher risk of suicidal ideationAdolescent tobaccoInfluence of cigaretteLevels of SESLogistic regressionCigaretteCessation programsTwo-weekMultiple social identitiesRiskAppropriate supportGinkgo biloba for Tardive Dyskinesia and Plasma MnSOD Activity: Association with MnSOD Ala-9Val Variant.
Wang D, Tian Y, Chen J, Zhu R, Li J, Zhou H, Chen D, Wang L, Kosten T, Zhang X. Ginkgo biloba for Tardive Dyskinesia and Plasma MnSOD Activity: Association with MnSOD Ala-9Val Variant. Current Neuropharmacology 2024, 22: 2443-2452. PMID: 38919004, DOI: 10.2174/1570159x22666240530095721.Peer-Reviewed Original ResearchAbnormal Involuntary Movement ScaleMnSOD Ala-9Val polymorphismTardive dyskinesiaTD patientsTD symptomsAla-9Val polymorphismPathophysiology of tardive dyskinesiaNon-TDHealthy controlsNon-TD patientsSeverity of TDMovement ScaleAla alleleDouble-blind clinical trialIncreased MnSOD activityMnSOD activityWeeks of treatmentVal/Val genotypeTreatment responseDyskinesiaGinkgo biloba extractEGb761 groupManganese superoxide dismutaseSymptomsClinical trialsEfficacy and Safety of Esmethadone (REL-1017) in Patients With Major Depressive Disorder and Inadequate Response to Standard Antidepressants: A Phase 3 Randomized Controlled Trial.
Fava M, Stahl S, Pani L, De Martin S, Cutler A, Maletic V, Gorodetzky C, Vocci F, Sapienza F, Kosten T, Kröger C, Champasa P, O'Gorman C, Guidetti C, Alimonti A, Comai S, Mattarei A, Folli F, Bushnell D, Traversa S, Inturrisi C, Manfredi P, Pappagallo M. Efficacy and Safety of Esmethadone (REL-1017) in Patients With Major Depressive Disorder and Inadequate Response to Standard Antidepressants: A Phase 3 Randomized Controlled Trial. The Journal Of Clinical Psychiatry 2024, 85 PMID: 38917366, DOI: 10.4088/jcp.24m15265.Peer-Reviewed Original ResearchConceptsMontgomery-Asberg Depression Rating ScaleIntent-to-treatIntent-to-treat analysisStandard antidepressantsDepressive disorderPost hoc analysisBaseline Montgomery-Asberg Depression Rating ScaleInadequate response to standard antidepressantsSevere depressionPost hoc analysis of patientsDepression Rating ScaleMajor depressive disorderAnalysis of patientsAdverse eventsMontgomery-AsbergConsistent with prior studiesPlacebo-controlled trialRating ScaleEfficacy measuresPer-protocolIntent-to-treat populationTreatment adherencePhase 3 randomized controlled trialsAdjunctive treatmentMDDEnhancing post-traumatic stress disorder patient assessment: leveraging natural language processing for research of domain criteria identification using electronic medical records
Miranda O, Kiehl S, Qi X, Brannock M, Kosten T, Ryan N, Kirisci L, Wang Y, Wang L. Enhancing post-traumatic stress disorder patient assessment: leveraging natural language processing for research of domain criteria identification using electronic medical records. BMC Medical Informatics And Decision Making 2024, 24: 154. PMID: 38835009, PMCID: PMC11151516, DOI: 10.1186/s12911-024-02554-8.Peer-Reviewed Original ResearchConceptsNatural language processingPost-traumatic stress disorderPost-traumatic stress disorder patientsRDoC domainsLanguage processingAbnormal instancesLeverage natural language processingDiagnosis of post-traumatic stress disorderDomain criteriaSimilarity threshold valueF1-macro scorePositive valence systemsHeightened cue reactivityElectronic medical recordsClinical notesF1 scoreCue reactivityStress disorderRDoCValence systemsReal-timeMental health improvementDisease trajectoryExtraction researchSensorimotor disturbancesLetter to the Editor regarding ‘Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-methadone’
Pappagallo M, Kosten T, Gorodetzky C, Vocci F, Sapienza F, De Martin S, Comai S, Mattarei A, Inturrisi C, Manfredi P. Letter to the Editor regarding ‘Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-methadone’. Molecular Psychiatry 2024, 1-3. PMID: 38806691, DOI: 10.1038/s41380-024-02621-6.Peer-Reviewed Original ResearchVaccines as Immunotherapies for Substance Use Disorders
Kosten T. Vaccines as Immunotherapies for Substance Use Disorders. American Journal Of Psychiatry 2024, 181: 362-371. PMID: 38706331, DOI: 10.1176/appi.ajp.20230828.Peer-Reviewed Original ResearchConceptsSubstance use disordersHuman clinical trials of vaccinesPreclinical vaccine studiesClinical trials of vaccinesVaccine clinical trialsHuman clinical trialsTrials of vaccinesVaccine immunotherapyIllicit fentanyl useOpioid pharmacotherapyEffective therapySubstance use disorder treatmentFentanyl useClinical trialsVaccine studiesAnimal modelsAnimal studiesUse disorderVaccine technologyLethal overdoseImmunotherapyVaccineLimited treatment accessFentanyl overdoseTreatment accessEfficacy and safety of psychedelics for the treatment of mental disorders: A systematic review and meta-analysis
Yao Y, Guo D, Lu T, Liu F, Huang S, Diao M, Li S, Zhang X, Kosten T, Shi J, Bao Y, Lu L, Han Y. Efficacy and safety of psychedelics for the treatment of mental disorders: A systematic review and meta-analysis. Psychiatry Research 2024, 335: 115886. PMID: 38574699, DOI: 10.1016/j.psychres.2024.115886.Peer-Reviewed Original ResearchConceptsMental disordersTreatment of mental disordersBorderline personality disorderObsessive-compulsive disorderTreat mood disordersSubstance-use disordersBody dysmorphic disorderPersonality disorderMood disordersDysmorphic disorderNegative moodEating disordersLasting adverse effectsTobacco addictionPsychedelicsDisordersTreat symptomsPsilocybinSleep disordersAyahuascaTherapeutic effectMeta-analyzedLSDPTSDMDMADeep sequencing of candidate genes identified 14 variants associated with smoking abstinence in an ethnically diverse sample
Cinciripini P, Wetter D, Wang J, Yu R, Kypriotakis G, Kumar T, Robinson J, Cui Y, Green C, Bergen A, Kosten T, Scherer S, Shete S. Deep sequencing of candidate genes identified 14 variants associated with smoking abstinence in an ethnically diverse sample. Scientific Reports 2024, 14: 6385. PMID: 38493193, PMCID: PMC10944542, DOI: 10.1038/s41598-024-56750-7.Peer-Reviewed Original ResearchConceptsIdentification of novel lociSequencing of candidate genesRare variant associationsMapped to genesReceptor signaling pathwayNovel lociGenes associated with regulationVariant associationsCandidate genesProtective lociDeep sequencingRegulation of bodyweightGenetic studiesCanonical pathwaysSignaling pathwayRare variantsGenetic profileTarget of pharmacotherapyTumor suppressionAssociated with cancerGenesPublic health tollRandomized controlled trialsSubstance use disordersEthnically diverse sample
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- December 21, 2021
Dr. Tom McMahon Looks Back