Taylor Adams
Research Associate 2 MSCards
About
Research
Publications
2026
Single-cell atlas of human lung aging identifies cell type dyssynchrony and increased transcriptional entropy
De Man R, McDonough J, Adams T, Nikola F, Rangel R, Anderson S, Manning E, Cala Garcia J, Moss B, Waich A, Poli F, Cardenas R, Coarfa C, Song Q, Bar-Joseph Z, Vanaudenaerde B, Wuyts W, Niklason L, Raredon M, Yan X, Rosas I, Kaminski N. Single-cell atlas of human lung aging identifies cell type dyssynchrony and increased transcriptional entropy. Nature Communications 2026, 17: 2095. PMID: 41571679, PMCID: PMC12953888, DOI: 10.1038/s41467-026-68810-9.Peer-Reviewed Original ResearchConceptsGenomic landscapeLung ageSingle-cell atlasAlveolar epithelialIndependent predictorsAnalysis of somatic mutationsSingle-cell dataSingle-cell RNA sequencingEndothelial cellsLoss of differentiationAlveolar epithelial cellsRNA sequencingTranscriptional changesCell-typeEndothelial cell typesSomatic mutationsMutational burdenAT2 cellsLung diseaseCell typesAge-related changesEpithelial cellsRisk factorsSenescence signatureEpithelial
2025
Keratinocytes as active regulators of cutaneous and mucosal immunity: a systematic review across inflammatory epithelial disorders
Klimitz F, Shen Y, Repetto F, Brown S, Knoedler L, Ko C, Abu Hussein N, Crisler W, Adams T, Kaminski N, Lian C, Murphy G, Hsia H, Pomahac B, Kauke-Navarro M. Keratinocytes as active regulators of cutaneous and mucosal immunity: a systematic review across inflammatory epithelial disorders. Frontiers In Immunology 2025, 16: 1694066. PMID: 41479908, PMCID: PMC12753988, DOI: 10.3389/fimmu.2025.1694066.Peer-Reviewed Original ResearchLichen planusLupus erythematosusAtopic dermatitisBullous pemphigoidMucosal inflammationInflammatory dermatosesSystematic reviewGraft-versus-host diseaseDisease-specific pathwaysImmune-mediated skin diseaseOral lichen planusTh2-skewed responseImmune cell recruitmentRegulation of immunityType I interferonSystematic review of studiesEpithelial disordersMucosal involvementEpithelial injuryImmune profileAlloimmune mechanismAntigen presentationGVHDChemokine releaseMucosal keratinocytes162 Sex-Specific monocyte interleukin signaling patterns in cystic fibrosis
Knight C, Yin H, Kizilirmak T, Adams T, Sauler M, Gomez J, Britto C. 162 Sex-Specific monocyte interleukin signaling patterns in cystic fibrosis. Journal Of Cystic Fibrosis 2025, 24: s95-s96. DOI: 10.1016/s1569-1993(25)01781-3.Peer-Reviewed Original ResearchSingle-cell analysis of cryobiopsy samples from patients with early IPF reveals loss of alveolar epithelial cells, and emergence of aberrant basaloid cells
Justet A, Adams T, Khoury J, Balayev A, Schupp J, Manning E, Zhao A, Ahangari F, Yan X, Ravaglia C, Poletti V, Tomasseti S, Kaminski N. Single-cell analysis of cryobiopsy samples from patients with early IPF reveals loss of alveolar epithelial cells, and emergence of aberrant basaloid cells. 2025, oa1196. DOI: 10.1183/13993003.congress-2025.oa1196.Peer-Reviewed Original ResearchSpatial Transcriptomics Profiling and Bulk RNA Sequencing to Assess Niches in End-Stage Silicosis
Abu Hussein N, Adams T, Anderson S, Kramer M, Nikola F, Robert R, Najjar A, Sharma P, Yang L, Zhang Y, Yan X, Pertzov B, Kaminski N. Spatial Transcriptomics Profiling and Bulk RNA Sequencing to Assess Niches in End-Stage Silicosis. 2025, pa6335. DOI: 10.1183/13993003.congress-2025.pa6335.Peer-Reviewed Original ResearchA deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases
Zheng Y, Schupp J, Adams T, Clair G, Justet A, Ahangari F, Yan X, Hansen P, Carlon M, Cortesi E, Vermant M, Vos R, De Sadeleer L, Rosas I, Pineda R, Sembrat J, Königshoff M, McDonough J, Vanaudenaerde B, Wuyts W, Kaminski N, Ding J. A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases. Nature Biomedical Engineering 2025, 9: 2155-2180. PMID: 40542107, PMCID: PMC12705450, DOI: 10.1038/s41551-025-01423-7.Peer-Reviewed Original ResearchComplex cellular dynamicsCellular dynamicsSingle-cell transcriptomic dataIn silico drug discoverySingle-cell transcriptomicsTranscriptome dataPotential therapeutic drug candidateComplex diseasesHuman diseasesIdiopathic pulmonary fibrosisTherapeutic drug candidateCell embeddingDrug discoveryPulmonary fibrosisDrug candidatesDisease progressionHuman tissuesHuman precision-cut lung slicesDynamic analysisPrecision-cut lung slicesPathological landscapeComputational toolsAnti-fibrotic effectsUnagiTranscriptomeUnderstanding and Reducing Cardiopulmonary Sequelae Associated With Chronic Hypoxia
Manning E, Ramachandra A, Sharma P, Nikola F, De Man R, Doddaballapur P, Raredon M, Szafron J, Baernthaler T, Justet A, Akingbesote N, Perry R, Adams T, Cavinato C, Yan X, Tellides G, Kaminski N, Humphrey J. Understanding and Reducing Cardiopulmonary Sequelae Associated With Chronic Hypoxia. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a3336-a3336. DOI: 10.1164/ajrccm.2025.211.abstracts.a3336.Peer-Reviewed Original ResearchThe Potential Role of miR205 and miR205HG in Pulmonary Fibrosis
Anderson S, Johad K, Ahangari F, Justet A, Adams T, Yan X, Kaminski N. The Potential Role of miR205 and miR205HG in Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a4662-a4662. DOI: 10.1164/ajrccm.2025.211.abstracts.a4662.Peer-Reviewed Original ResearchEarly IPF is Characterized by a Dramatic Shift of the Epithelial and Endothelial Populations Within the Alveolar Niche
Justet A, Adams T, Khoury J, Balayev A, Abu Hussein N, Schupp J, Zhao A, Manning E, Ahangari F, Yan X, Ravaglia C, Tomassetti S, Poletti V, Kaminski N. Early IPF is Characterized by a Dramatic Shift of the Epithelial and Endothelial Populations Within the Alveolar Niche. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a7109-a7109. DOI: 10.1164/ajrccm.2025.211.abstracts.a7109.Peer-Reviewed Original ResearchThe Potential Role of GPR87 in the Development of Pulmonary Fibrosis
Khoury J, Ahangari F, Justet A, Adams T, Manning E, Mcdonough J, Anderson S, Nekola F, Beermann M, Bauer Y, Gomez J, Kaminski N. The Potential Role of GPR87 in the Development of Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a7110-a7110. DOI: 10.1164/ajrccm.2025.211.abstracts.a7110.Peer-Reviewed Original Research