Talal El Zarif

Featured Publications

• Safety and efficacy of immune checkpoint therapy for the treatment of patients with cardiac metastasis: a multicenter international retrospective study

  Nassar A, Alaiwi S, Zarif T, Denu R, Macaron W, Abdel-Wahab N, Freeman D, Vasbinder A, Hayeck S, Anderson E, Goodman R, Johnson D, Grynberg S, Shapira R, Kwan J, Woodford R, Long G, Haykal T, Dent S, Kojima Y, Yonemor K, Tandon A, Trevino A, Akhter N, Yang E, Hui G, Drakaki A, El-Am E, Kozaily E, Al-Hader A, Farhat E, Babu P, Mittra A, Li M, Jones N, Baena J, Herrera M, Foderaro S, Nana F, Kim C, Sackstein P, Parikh K, Desai A, Smith C, Cortellini A, Pinato D, Korolewicz J, Lopetegui-Lia N, Funchain P, Choudhary A, Asnani A, Navani V, Meyers D, Stukalin I, Gallegos J, Trent J, Nusrat S, Malvar C, McKay R, Neilan T, Choueiri T, Naqash A. Safety and efficacy of immune checkpoint therapy for the treatment of patients with cardiac metastasis: a multicenter international retrospective study. Journal For ImmunoTherapy Of Cancer 2025, 13: e009364. PMID: 40032601, PMCID: PMC11877189, DOI: 10.1136/jitc-2024-009364.

  Peer-Reviewed Original Research

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• How to Use Imaging: Complex Cases of Atherosclerosis, Myocardial Inflammation, and Cardiomyopathy in Cardio-Oncology

  Khattab M, Baig M, Zarif T, Barac A, Ferencik M, Henry M, Lopez-Mattei J, Redheuil A, Salem J, Scherrer-Crosbie M, Yang E, Baldassarre L. How to Use Imaging: Complex Cases of Atherosclerosis, Myocardial Inflammation, and Cardiomyopathy in Cardio-Oncology. Circulation Cardiovascular Imaging 2025, 18: e015981. PMID: 39772610, DOI: 10.1161/circimaging.124.015981.

  Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

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• First-line Systemic Therapy Following Adjuvant Immunotherapy in Renal Cell Carcinoma: An International Multicenter Study

  El Zarif T, Semaan K, Xie W, Eid M, Zarba M, Issa W, Zhang T, Nguyen C, Alva A, Fahey C, Beckermann K, Karam J, Campbell M, Procopio G, Stellato M, Buti S, Zemankova A, Melichar B, Massari F, Mollica V, Venugopal B, Ebrahimi H, de Velasco G, Gurney H, De Giorgi U, Parikh O, Winquist E, Master V, Garcia A, Cutuli H, Ferguson T, Gross-Goupil M, Baca S, Pal S, Braun D, McKay R, Heng D, Choueiri T. First-line Systemic Therapy Following Adjuvant Immunotherapy in Renal Cell Carcinoma: An International Multicenter Study. European Urology 2024, 86: 503-512. PMID: 39147674, DOI: 10.1016/j.eururo.2024.07.016.

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• Gastrointestinal Cancer Therapy and Cardiotoxicity

  Leiva O, Zarif T, Alvarez-Cardona J. Gastrointestinal Cancer Therapy and Cardiotoxicity. Current Treatment Options In Oncology 2024, 25: 1203-1209. PMID: 39102169, DOI: 10.1007/s11864-024-01236-x.

  Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

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• Detecting small cell transformation in patients with advanced EGFR mutant lung adenocarcinoma through epigenomic cfDNA profiling

  Zarif T, Meador C, Qiu X, Seo J, Davidsohn M, Savignano H, Lakshminarayanan G, McClure H, Canniff J, Fortunato B, Li R, Banwait M, Semaan K, Eid M, Long H, Hung Y, Mahadevan N, Barbie D, Oser M, Piotrowska Z, Choueiri T, Baca S, Hata A, Freedman M, Berchuck J. Detecting small cell transformation in patients with advanced EGFR mutant lung adenocarcinoma through epigenomic cfDNA profiling. Clinical Cancer Research 2024, 30: 3798-3811. PMID: 38912901, PMCID: PMC11369616, DOI: 10.1158/1078-0432.ccr-24-0466.

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• Epigenomic signatures of sarcomatoid differentiation to guide the treatment of renal cell carcinoma

  Zarif T, Semaan K, Eid M, Seo J, Garinet S, Davidsohn M, Sahgal P, Fortunato B, Canniff J, Nassar A, Alaiwi S, Bakouny Z, Lakshminarayanan G, Savignano H, Lyons K, Matar S, Ali A, Saad E, Saliby R, Cordeiro P, Zhang Z, Ahmar N, Laimon Y, Labaki C, Shah V, Freeman D, O’Toole J, Lee G, Hwang J, Pomerantz M, Signoretti S, Van Allen E, Xie W, Berchuck J, Viswanathan S, Braun D, Choueiri T, Freedman M, Baca S. Epigenomic signatures of sarcomatoid differentiation to guide the treatment of renal cell carcinoma. Cell Reports 2024, 43: 114350. PMID: 38870013, PMCID: PMC11929466, DOI: 10.1016/j.celrep.2024.114350.

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• Anticoagulants or antiplatelets for secondary prevention of cryptogenic stroke: an updated systematic review and meta-analysis

  Chi K, Zarif T, Varrias D, Lee P, Chang Y, Song J, Osabutey A, Borkowski P, Chiang C, Chang Y, Lin Y, Nanna M, Nanna M. Anticoagulants or antiplatelets for secondary prevention of cryptogenic stroke: an updated systematic review and meta-analysis. Heart 2025, 111: 495-505. PMID: 39915077, PMCID: PMC12068992, DOI: 10.1136/heartjnl-2024-325288.

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• Clinical Outcomes Among Immunotherapy-Treated Patients With Primary Cardiac Soft Tissue Sarcomas A Multicenter Retrospective Study

  Nassar A, El-Am E, Denu R, Alaiwi S, Zarif T, Macaron W, Abdel-Wahab N, Desai A, Smith C, Parikh K, Abbasi M, Farhat E, Williams J, Collins J, Al-Hader A, McKay R, Malvar C, Sabra M, Zhong C, Alam R, Chehab O, Lima J, Phan M, Pria H, Trevino A, Neilan T, Kwan J, Ravi V, Deshpande H, Demetri G, Choueiri T, Naqash A. Clinical Outcomes Among Immunotherapy-Treated Patients With Primary Cardiac Soft Tissue Sarcomas A Multicenter Retrospective Study. JACC CardioOncology 2024, 6: 71-79. PMID: 38510282, PMCID: PMC10950431, DOI: 10.1016/j.jaccao.2023.11.007.

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• Safety and efficacy of immune checkpoint inhibitors in advanced penile cancer: report from the Global Society of Rare Genitourinary Tumors

  El Zarif T, Nassar A, Pond G, Zhuang T, Master V, Nazha B, Niglio S, Simon N, Hahn A, Pettaway C, Tu S, Abdel-Wahab N, Velev M, Flippot R, Buti S, Maruzzo M, Mittra A, Gheeya J, Yang Y, Rodriguez P, Castellano D, de Velasco G, Roviello G, Antonuzzo L, McKay R, Vincenzi B, Cortellini A, Hui G, Drakaki A, Glover M, Khaki A, El-Am E, Adra N, Mouhieddine T, Patel V, Piedra A, Gernone A, Davis N, Matthews H, Harrison M, Kanesvaran R, Giudice G, Barata P, Farolfi A, Lee J, Milowsky M, Stahlfeld C, Appleman L, Kim J, Freeman D, Choueiri T, Spiess P, Necchi A, Apolo A, Sonpavde G. Safety and efficacy of immune checkpoint inhibitors in advanced penile cancer: report from the Global Society of Rare Genitourinary Tumors. Journal Of The National Cancer Institute 2023, 115: 1605-1615. PMID: 37563779, PMCID: PMC11032703, DOI: 10.1093/jnci/djad155.

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• Liquid biopsy epigenomic profiling for cancer subtyping

  Baca S, Seo J, Davidsohn M, Fortunato B, Semaan K, Sotudian S, Lakshminarayanan G, Diossy M, Qiu X, El Zarif T, Savignano H, Canniff J, Madueke I, Saliby R, Zhang Z, Li R, Jiang Y, Taing L, Awad M, Chau C, DeCaprio J, Figg W, Greten T, Hata A, Hodi F, Hughes M, Ligon K, Lin N, Ng K, Oser M, Meador C, Parsons H, Pomerantz M, Rajan A, Ritz J, Thakuria M, Tolaney S, Wen P, Long H, Berchuck J, Szallasi Z, Choueiri T, Freedman M. Liquid biopsy epigenomic profiling for cancer subtyping. Nature Medicine 2023, 29: 2737-2741. PMID: 37865722, PMCID: PMC10695830, DOI: 10.1038/s41591-023-02605-z.

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