Shaili Gupta, MBBS, MHS
Associate Professor of Medicine (General Medicine)Cards
Additional Titles
Associate Program Director for Program Policy and Professional Development, Trad IM Residency Program, Department of Medicine
Director of Innovation in Healthcare and Professional Development, Education, VACHS
Contact Info
General Internal Medicine
Yale Department of Internal Medicine-Education , 330 Cedar Street, LMP 1093 PO Box 208030
New Haven, CT 06520-8030
United States
Director of AI and Innovation in Medicine Distinction Pathway, Internal Medicine
Additional Titles
Associate Program Director for Program Policy and Professional Development, Trad IM Residency Program, Department of Medicine
Director of Innovation in Healthcare and Professional Development, Education, VACHS
Contact Info
General Internal Medicine
Yale Department of Internal Medicine-Education , 330 Cedar Street, LMP 1093 PO Box 208030
New Haven, CT 06520-8030
United States
Director of AI and Innovation in Medicine Distinction Pathway, Internal Medicine
Additional Titles
Associate Program Director for Program Policy and Professional Development, Trad IM Residency Program, Department of Medicine
Director of Innovation in Healthcare and Professional Development, Education, VACHS
Contact Info
General Internal Medicine
Yale Department of Internal Medicine-Education , 330 Cedar Street, LMP 1093 PO Box 208030
New Haven, CT 06520-8030
United States
Director of AI and Innovation in Medicine Distinction Pathway, Internal Medicine
About
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Titles
Associate Professor of Medicine (General Medicine)
Associate Program Director for Program Policy and Professional Development, Trad IM Residency Program, Department of Medicine
Positions outside Yale
Director of Innovation in Healthcare and Professional Development, Education, VACHS
Biography
Dr Gupta is a clinician-educator with expertise in medical education, artificial intelligence, professionalism development and clinical virology. She is an Associate Program Director for Yale Internal Medicine residency program, and the Director of Innovation and Professional Development at the VA. Dr. Gupta has been serving as research supervisor, thesis advisor and mentor to students, residents, fellows and faculty for more than a decade, and is passionate about career development for her mentees. She completed her fellowship training in Infectious Diseases at Yale in 2008, and currently divides her time between providing patient care for veterans admitted to the VA hospital, education for trainees, and medical education research. She is the director of AI and Innovation in Medicine distinction pathway that provides advanced learning in AI, machine learning and clinical applications to residents.
Appointments
General Internal Medicine
Associate Professor on TermPrimary
Other Departments & Organizations
Education & Training
- MHS
- Yale School of Medicine, Medical Education
- Fellowship
- Yale University School of Medicine (2008)
- Residency
- University of Maryland, Union Memorial Hospital (2006)
- MBBS
- Sawai Man Singh Medical College (1998)
Board Certifications
Infectious Diseases
- Certification Organization
- AB of Internal Medicine
- Latest Certification Date
- 2018
- Original Certification Date
- 2008
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Latest Certification Date
- 2016
- Original Certification Date
- 2006
Research
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Overview
Dr. Gupta has extensive experience in viral variants and mutations that impact clinical outcomes of viral diseases. Her research work has ranged from investigation of minority resistant variants of HIV and the management of treatment-experienced HIV+ individuals, to evaluation of clinical outcomes among multidrug resistant HIV+ individuals, patients co-infected with HIV and viral Hepatitis, and individuals with bacterial pyogenic arthritis. She has written on rapid diagnostic platforms for bloodstream infections, and has been conducting research on medical education in healthcare settings. During the COVID-19 pandemic, her research was focused on evaluating genomic and immunological interplay of SARS-CoV-2. She has been conducting epidemiologic and outcomes analyses on veterans diagnosed with COVID-19 across the six New England states through her active clinical and virologic repository, including dynamic evaluation of SARS-CoV-2 variants. She has also been conducting research into the clinical and demographic correlations of vaccine-generated immune responses.
ORCID
0000-0001-9508-0995
Research at a Glance
Yale Co-Authors
Publications Timeline
Naseema Merchant, FCCP, FACP, FHM, MBBS
Craig Gunderson, MD, SFHM
Sheldon Campbell, MD, PhD
Tassos C. Kyriakides, PhD
Louise-Marie Dembry, MD, FACP, MS, MBA, FIDSA, BS
Andrea Asnes, MD, MSW
Publications
2025
CoVimmune COVID-19 Immunity Calculator: Web Application Development and Validation Study
Slotkin R, Kyriakides T, Yu V, Chen X, Kundu A, Gupta S. CoVimmune COVID-19 Immunity Calculator: Web Application Development and Validation Study. JMIR Formative Research 2025, 9: e59467. PMID: 40262279, PMCID: PMC12040297, DOI: 10.2196/59467.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and Concepts
2024
Developing CLOUT: A Longitudinal, Cross-Program Chief Resident Curriculum to Increase Psychological Safety in the Clinical Learning Environment
Dunne D, Asnes A, Berg D, Chen A, Dewey J, Gupta S, Fernandes C, Huot S. Developing CLOUT: A Longitudinal, Cross-Program Chief Resident Curriculum to Increase Psychological Safety in the Clinical Learning Environment. Academic Medicine 2024, 99: s87-s91. PMID: 39601612, DOI: 10.1097/acm.0000000000005871.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsClinical learning environmentLearning environmentPsychological safetyProfessional development curriculumSelf-regulation of emotionFaculty alliesIndividual self-efficacyDevelopment curriculumIncrease psychological safetyPromote psychological safetyChief residentsCurriculumCurriculum's impactSkills-based workshopInstitutional climateSelf-RegulationSelf-EfficacyEffective coachingEvidence of behavior changeRelationship buildingLeadership positionsWorkplace mistreatmentLongitudinal curriculumCohort modelBehavioral changes
2022
Long-term quantitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID-19 vaccination in older people living with HIV (PWH)
Tuan JJ, Zapata H, Barakat L, Andrews L, Behnegar A, Kim YW, Kayani J, Mutic S, Ryall L, Turcotte B, Critch-Gilfillan T, Zhao M, Salahuddin S, Gupta S, Sutton R, Friedland G, Emu B, Ogbuagu O. Long-term quantitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID-19 vaccination in older people living with HIV (PWH). BMC Infectious Diseases 2022, 22: 744. PMID: 36131232, PMCID: PMC9491266, DOI: 10.1186/s12879-022-07737-0.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsT cell responsesAnti-spike IgGVisit 3SARS-CoV-2Older PWHVisit 2Immune responseSingle-center longitudinal observational studyVirus-specific T cell responsesVaccine-induced humoral immunityLong-term protective immunityT cell immune responsesOlder peopleMedian age 61RBD IgG levelsPrimary study outcomeCOVID-19 vaccinationImmune response evaluationLongitudinal observational studyCOVID-19 vaccineWilcoxon signed-rank testBNT162b2 boosterBNT162b2 vaccinationCD8 responsesDetectable CD4Serum Neutralizing Antibody Titers 12 Months After Coronavirus Disease 2019 Messenger RNA Vaccination: Correlation to Clinical Variables in an Adult, US Population
Zhao M, Slotkin R, Sheth AH, Pischel L, Kyriakides TC, Emu B, McNamara C, Shi Q, Delgobbo J, Xu J, Marhoffer E, Mercer-Falkoff A, Holleck J, Ardito D, Sutton RE, Gupta S. Serum Neutralizing Antibody Titers 12 Months After Coronavirus Disease 2019 Messenger RNA Vaccination: Correlation to Clinical Variables in an Adult, US Population. Clinical Infectious Diseases 2022, 76: e391-e399. PMID: 35639598, PMCID: PMC9278145, DOI: 10.1093/cid/ciac416.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMonth postboosterRNA vaccinationClinical variablesNeutralization responseEnd-stage renal diseaseBooster dose responsePrimary series vaccinationPrimary vaccine seriesMultiple clinical factorsSystemic steroid useDoses of vaccinePrior COVID-19Maximal inhibitory concentration valuesHalf maximal inhibitory concentration (IC50) valuesSeries vaccinationVaccine seriesVaccine regimensClinical factorsDiabetes mellitusRenal diseaseComorbid conditionsSteroid useCOVID infectionImmune responseUS populationDevelopment of an efficient reproducible cell-cell transmission assay for rapid quantification of SARS-CoV-2 spike interaction with hACE2
Ssenyange G, Kerfoot M, Zhao M, Farhadian S, Chen S, Peng L, Ren P, Dela Cruz CS, Gupta S, Sutton RE. Development of an efficient reproducible cell-cell transmission assay for rapid quantification of SARS-CoV-2 spike interaction with hACE2. Cell Reports Methods 2022, 2: 100252. PMID: 35757815, PMCID: PMC9213030, DOI: 10.1016/j.crmeth.2022.100252.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAnti-spike monoclonal antibodiesTransmission assaysTherapeutic antiviral drugsSARS-CoV-2Quantitative readoutVirus-cell bindingRapid quantificationConvalescent seraNeutralization assaysAntiviral drugsResearch reagentsSmall molecule drugsClinical settingViral replicationPseudotyped particlesMonoclonal antibodiesLaboratory equipmentQuantitative assayClinical and virologic factors associated with outcomes of COVID‐19 before and after vaccination among Veterans: Retrospective analysis from six New England states
Lee M, Cosentino D, Kyriakides TC, Cavallaro T, Stack G, Gupta S. Clinical and virologic factors associated with outcomes of COVID‐19 before and after vaccination among Veterans: Retrospective analysis from six New England states. Journal Of Hospital Medicine 2022, 17: 534-538. PMID: 35661577, PMCID: PMC9348310, DOI: 10.1002/jhm.12852.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsCOVID-19Intensive care unit admissionVeterans Administration Healthcare SystemCare unit admissionNonpsychiatric hospitalizationsVirologic factorsFull vaccinationUnit admissionICU careClinical outcomesPoor outcomeMean ageRetrospective analysisD614G mutationHealthcare systemVeteransNew England statesHospitalizationOlder cohortOutcomesViral epidemiologyVaccinationDemographic factorsG mutationAgePancreatic Neuroendocrine Tumor Presenting with Chylous Ascites: Multidisciplinary Workup to Differentiate from Malignant Ascites
Ilagan-Ying YC, Park EY, Lam R, Gupta S. Pancreatic Neuroendocrine Tumor Presenting with Chylous Ascites: Multidisciplinary Workup to Differentiate from Malignant Ascites. Journal Of General Internal Medicine 2022, 37: 2082-2085. PMID: 35260958, PMCID: PMC9198176, DOI: 10.1007/s11606-022-07463-y.Peer-Reviewed Case Reports and Technical NotesCitationsAltmetric
2021
COVID-19 Outcomes and Genomic Characterization of SARS-CoV-2 Isolated From Veterans in New England States: Retrospective Analysis
Lee M, Sallah YH, Petrone M, Ringer M, Cosentino D, Vogels CBF, Fauver JR, Alpert TD, Grubaugh ND, Gupta S. COVID-19 Outcomes and Genomic Characterization of SARS-CoV-2 Isolated From Veterans in New England States: Retrospective Analysis. JMIRx Med 2021, 2: e31503. PMID: 35014989, PMCID: PMC8722526, DOI: 10.2196/31503.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSARS-CoV-2 infectionPeak disease severityCOVID-19 outcomesChart reviewMean ageDisease severityHigher comorbidity burdenRetrospective chart reviewSARS-CoV-2 RNACohort of veteransGeneral US populationNon-white raceCOVID-19 infectionManual chart reviewSARS-CoV-2Multivariate regression analysisO2 requirementsNon-white veteransSARS-CoV-2 lineagesComorbidity burdenVirologic factorsD614G substitutionMultiple SARS-CoV-2 lineagesVirologic characteristicsClinical outcomesFalling Through the Cracks
Gupta S, Klebanoff MJ, Pathak A, Unaka NI, Herbst B. Falling Through the Cracks. Journal Of Hospital Medicine 2021, 16: 694-698. PMID: 34328836, DOI: 10.12788/jhm.3578.Peer-Reviewed Original ResearchAltmetric
2020
Advances in rapid diagnostics for bloodstream infections
Briggs N, Campbell S, Gupta S. Advances in rapid diagnostics for bloodstream infections. Diagnostic Microbiology And Infectious Disease 2020, 99: 115219. PMID: 33059201, DOI: 10.1016/j.diagmicrobio.2020.115219.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and Concepts
Academic Achievements & Community Involvement
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Activities
activity Yale School of Medicine Faculty Advisory Committee to the Dean
10/01/2020 - PresentCommitteesAdvisoractivity Yale School of Medicine DEI Subcommittee
04/01/2021 - PresentCommitteesAdvisoractivity VA Connecticut Healthcare Systems COVID-19 Treatment Committee
03/25/2020 - PresentCommitteesAdvisoractivity VA Connecticut Healthcare Systems, DEI Committee
2021 - PresentCommitteesCommittee Memberactivity Open Forum Infectious Diseases
2022 - PresentJournal ServiceReviewer
Honors
honor The Asghar Rasteghar, MD Teacher of the Year Award
06/02/2023, 05/27/2020Yale School of Medicine AwardYale Internal Medicine Residency ProgramDetailsUnited Stateshonor Nominated for Charles W. Bohmfalk Teaching award in Clinical Sciences
07/14/2021Yale School of Medicine AwardDetailsUnited Stateshonor Veterans Health Affairs Secretary's Coin of Excellence
09/17/2020National AwardVeterans Affairs Healthcare Systems of USADetailsUnited Stateshonor Outstanding Medical Resident
06/20/2006Regional AwardUnion Memorial Hospital, University of Maryland, Baltimore, MDDetailsUnited States
News
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News
- December 02, 2025
Bridging Medicine and Technology: Yale’s New AI Distinction Pathway
- March 21, 2025
Match Day 2025: Yale Internal Medicine Welcomes Incoming Residents
- December 02, 2024
YSM Faculty Honored by American College of Physicians
- March 15, 2024
Announcing the New Residents in the Yale-Waterbury Internal Medicine Residency Program!
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Contacts
General Internal Medicine
Yale Department of Internal Medicine-Education , 330 Cedar Street, LMP 1093 PO Box 208030
New Haven, CT 06520-8030
United States