Saseong Lee
Associate Research ScientistCards
About
Research
Publications
2026
The therapeutic effects of the VEGF decoy receptor fusion protein VEGF-Grab in chronic inflammatory diseases
Lee Y, Lee H, Lim H, Shin J, Yang H, Lee S, Mercadante G, Cicatiello V, De Falco S, Kim H, Kim C, Lee S, Kim Y, Yoo S, Lee S, Kim W. The therapeutic effects of the VEGF decoy receptor fusion protein VEGF-Grab in chronic inflammatory diseases. EBioMedicine 2026, 126: 106216. PMID: 41861515, PMCID: PMC13015212, DOI: 10.1016/j.ebiom.2026.106216.Peer-Reviewed Original ResearchExperimental autoimmune encephalomyelitisVEGF-GrabAutoimmune diseasesTherapeutic effectRheumatoid arthritisMultiple sclerosisTh17 cellsPathogenic T helper type 17Decoy receptor fusion proteinAnimal models of autoimmune diseaseAnimal modelsT helper type 17Experimental autoimmune encephalomyelitis modelModels of autoimmune diseasesTherapeutic efficacy in vivoPathogenesis of autoimmune diseasesPlacental growth factorPathogenic Th17 cellsWound healing assayImmune-cell functionPathogenicity of Th17 cellsChronic inflammatory diseaseEfficacy in vivoTreatment of RAReceptor fusion protein
2025
POS0010 A Novel Therapeutic Effect of VEGF Decoy Receptor Fusion Protein, VEGF-Grab, in Chronic Inflammatory Diseases
Lee H, Lee Y, Lee K, Park S, Kim J, Kim S, Lim H, Shin J, Yang H, Lee S, Cho C, Yoo S, Lee S, Kim W. POS0010 A Novel Therapeutic Effect of VEGF Decoy Receptor Fusion Protein, VEGF-Grab, in Chronic Inflammatory Diseases. Annals Of The Rheumatic Diseases 2025, 84: 329-330. DOI: 10.1016/j.ard.2025.05.407.Peer-Reviewed Original ResearchPlacental growth factorExperimental autoimmune encephalomyelitisDecoy receptor fusion proteinVEGF-GrabTh17 cellsCollagen-induced arthritisAdjuvant-induced arthritisTherapeutic effectAutoimmune diseasesReceptor fusion proteinRheumatoid arthritisMultiple sclerosisGrowth factorTherapeutic potentialFusion proteinPathogenic function of Th17 cellsMouse modelExperimental autoimmune encephalomyelitis model of multiple sclerosisGeneration of Th17 cellsVascular endothelial growth factor receptor 1Experimental autoimmune encephalomyelitis modelFunction of Th17 cellsPathological vessel formationModel of multiple sclerosisIn vivo Matrigel plug assayAsthma Alleviation by Ginsenoside Rb1 via Promotion of Treg Proliferation and Inflammatory T Cell Inhibition
Choi S, Yoo S, Ji K, Jung D, Lee S, Lee K, Kim K, Lee J, Jung M, Pyun B, Hur J, Choi J, Rhee C, Kim W, Kim T. Asthma Alleviation by Ginsenoside Rb1 via Promotion of Treg Proliferation and Inflammatory T Cell Inhibition. Allergy 2025, 80: 1647-1668. PMID: 40251907, PMCID: PMC12186593, DOI: 10.1111/all.16551.Peer-Reviewed Original ResearchConceptsTreg populationTreg proliferationTh17 populationT cellsHealthy donorsIL-10Conventional T cellsRegulatory T cellsT cell inhibitionT cell populationsCytometric bead arrayT cell balanceTNF-a expressionMouse asthma modelAsthma model miceInflammatory cytokine secretionEffects of GRb1Elevated TregTreg activityLiving drugsIL-17ACytokine analysisTregsIFN-gCytokine secretion
2024
The acute phase reactant orosomucoid-2 directly promotes rheumatoid inflammation
Kim K, Lee K, Lee S, Hong B, Yun H, Park Y, Yoo S, Kim W. The acute phase reactant orosomucoid-2 directly promotes rheumatoid inflammation. Experimental & Molecular Medicine 2024, 56: 890-903. PMID: 38556552, PMCID: PMC11058272, DOI: 10.1038/s12276-024-01188-0.Peer-Reviewed Original ResearchConceptsOrosomucoid 2Intra-articular injectionRheumatoid arthritisRA patientsProteomic profiling of serumGlobal proteomic profilingRheumatoid inflammationInfiltration of macrophagesProduction of proinflammatory mediatorsSeverity of arthritisChronic inflammatory diseaseAcute phase reactantsProfiling of serumSynovial membrane of RA patientsFibroblast-like synoviocytesP38 MAPK pathwayRadiographic progressionSynovial membraneCCL2 productionTNF-aProinflammatory mediatorsIL-8Inflammatory diseasesIL-6Phase reactantsNuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis
Lee K, Hong B, Lee S, Lee N, Kim S, Kim D, Kim W. Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis. Cellular & Molecular Immunology 2024, 21: 227-244. PMID: 38195836, PMCID: PMC10902316, DOI: 10.1038/s41423-023-01121-x.Peer-Reviewed Original ResearchConceptsNuclear receptor coactivator 6Regulation of NLRP3 inflammasome activationRate of gene expressionNLRP3 inflammasome activationActivate caspase-1Gain-of-function mutationsTranscriptome profiling resultsInflammasome activationHydrolysis motifAcute tubular necrosisProduction of IL-1bTranscriptional coactivatorNACHT domain of NLRP3NACHT domainGene expressionEmbryonic developmentInnate immunityGenetic ablationCaspase-1Gout patientsCrystal-induced arthritisTubular necrosisActivated monocytesProinflammatory conditionsIL-1B
2023
OP0291 ACUTE PHASE REACTANT OROSOMUCOID-2 DIRECTLY PROMOTES RHEUMATOID INFLAMMATION
Kim K, Lee S, Lee K, Hong B, Park Y, Yoo S, Kim W. OP0291 ACUTE PHASE REACTANT OROSOMUCOID-2 DIRECTLY PROMOTES RHEUMATOID INFLAMMATION. Annals Of The Rheumatic Diseases 2023, 82: 190. DOI: 10.1136/annrheumdis-2023-eular.1474.Peer-Reviewed Original ResearchAcute phase reactantsRheumatoid arthritisPhase reactantsIntra-articular injectionNF-kBSynovial macrophagesInjection of C-reactive proteinChronic inflammationRA patientsTNF-aProduction of pro-inflammatory cytokines/chemokinesFeed-forward cycleToll-like receptor 4 agonistDiagnostic markerGlycophorin CPro-inflammatory cytokines/chemokinesProduction of pro-inflammatory cytokinesSerum diagnostic markersC-reactive proteinInfiltration of macrophagesSeverity of arthritisChronic inflammatory diseaseFibroblast-like synoviocytesPro-inflammatory cytokinesReactantsIdentification of MYH9 as a key regulator for synoviocyte migration and invasion through secretome profiling
Lee S, Choi E, Chae S, Koh J, Choi Y, Kim J, Yoo S, Hwang D, Kim W. Identification of MYH9 as a key regulator for synoviocyte migration and invasion through secretome profiling. Annals Of The Rheumatic Diseases 2023, 82: 1035-1048. PMID: 37188496, PMCID: PMC10359537, DOI: 10.1136/ard-2022-223625.Peer-Reviewed Original ResearchConceptsMyosin heavy chain 9Actin-based cell motilityTranscriptome profilingExpression levelsSecretome profileParallel Reaction Monitoring analysisLiquid chromatography-tandem mass spectrometry analysisRA-FLSCell motilityMass spectrometry analysisSecreted proteinsFibroblasts of patientsReceptor ligationToll-like receptor ligationRheumatoid arthritisWestern blot analysisCultured RA-FLSHeavy chain 9Pathological hallmarkComprehensive resourceInvasion of RA-FLSCell typesBlot analysisImmuno-deficient miceProteinRole of high-temperature requirement serine protease A 2 in rheumatoid inflammation
Jeong G, Nam M, Hur W, Heo S, Lee S, Choi E, Park J, Park Y, Kim W, Rhim H, Yoo S. Role of high-temperature requirement serine protease A 2 in rheumatoid inflammation. Arthritis Research & Therapy 2023, 25: 96. PMID: 37287073, PMCID: PMC10246393, DOI: 10.1186/s13075-023-03081-z.Peer-Reviewed Original ResearchConceptsLPS-induced releaseInterleukin-6Interleukin-8Rheumatoid arthritisLPS-induced release of proinflammatory cytokinesRelease of proinflammatory cytokinesSynovial fluid of RA patientsSynovial fluidTumor necrosis factor-aSynovial tissue of patientsSynovial tissueC-C motifTissues of patientsAnti-inflammation therapyEnzyme-linked immunosorbent assayExpression of proinflammation cytokinesImmune cellsER stress inducersProinflammatory cytokinesRA patientsRA SFInflammatory mediatorsPrimary synoviocytesImmune responseImmunofluorescence staining
2021
Genetic deficiency of nuclear factor of activated T cells 5 attenuates the development of osteoarthritis in mice
Lee J, Lee J, Lee S, Yoo S, Kim K, Kim W, Cho C, Yoon C. Genetic deficiency of nuclear factor of activated T cells 5 attenuates the development of osteoarthritis in mice. Joint Bone Spine 2021, 89: 105273. PMID: 34537377, DOI: 10.1016/j.jbspin.2021.105273.Peer-Reviewed Original ResearchConceptsNuclear factor of activated T cells 5Expression of CCL2IL-1BGenetic deficiencyExpression of nuclear factor of activated T cells 5Synovial inflammationNuclear factorWild-typeSeverity of synovial inflammationNFAT5 expressionMMP-13Male C57BL/6Macrophage infiltrationMacrophage recruitmentCCL2 expressionCartilage degrading enzymesInflammatory cytokinesHaplo-insufficiencyIL-6CCL2ERK pathwayKnee jointMiceP38 MAPKTherapeutic target
2020
Development of Monitoring System for Assessing Rheumatoid Arthritis within 5 Minutes Using a Drop of Bio-Fluids
Koh J, Lee S, Kim H, Lee K, Lee C, Yoo S, Lee N, Kim W. Development of Monitoring System for Assessing Rheumatoid Arthritis within 5 Minutes Using a Drop of Bio-Fluids. Journal Of Clinical Medicine 2020, 9: 3499. PMID: 33138147, PMCID: PMC7692111, DOI: 10.3390/jcm9113499.Peer-Reviewed Original ResearchRA activitySCD14 concentrationsDisease activityRheumatoid arthritisSerum of RA patientsDisease Activity ScoreAnti-rheumatic drugsC-reactive proteinFrequent monitoringSerum sCD14 concentrationsValidated scoring systemSCD14 valuesSCD14 levelsSoluble CD14Treatment responseDiagnostic performanceActivity scoreRA patientsTherapeutic outcomesDrop of serumSCD14Scoring systemRA statusMolecular assaysSerum
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