2023
α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease
Martin-Lopez E, Vidyadhara D, Liberia T, Meller S, Harmon L, Hsu R, Spence N, Brennan B, Han K, Yücel B, Chandra S, Greer C. α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease. Journal Of Neuroscience 2023, 43: 1051-1071. PMID: 36596700, PMCID: PMC9908323, DOI: 10.1523/jneurosci.1526-22.2022.Peer-Reviewed Original ResearchConceptsΑ-syn tg miceΑ-Syn pathologyOlfactory bulb neurogenesisProjection neuronsParkinson's diseaseOlfactory dysfunctionMutant α-synucleinOlfactory deficitsOlfactory pathwaySyn pathologyBehavioral deficitsMouse modelΑ-synucleinOB granule cellsΑ-synuclein pathologyOlfactory systemMonths of ageReduced neurogenesisFunctional deficitsPeriglomerular cellsMotor progressionPathologic changesMultiple symptomsSynaptic terminalsGranule cells
2019
Sequential maturation of olfactory sensory neurons in the mature olfactory epithelium
Liberia T, Martin-Lopez E, Meller SJ, Greer CA. Sequential maturation of olfactory sensory neurons in the mature olfactory epithelium. ENeuro 2019, 6: eneuro.0266-19.2019. PMID: 31554664, PMCID: PMC6795559, DOI: 10.1523/eneuro.0266-19.2019.Peer-Reviewed Original ResearchConceptsOlfactory sensory neuronsOlfactory epitheliumOSN axonsSensory neuronsBasal cell divisionNew olfactory sensory neuronsYoung adultsMature olfactory epitheliumYoung adult micePostnatal day 25Olfactory bulb glomeruliMolecular maturationFate mapping strategyOlfactory nerveSpecific glomeruliCribriform plateAdult miceGAP-43Day 25Time pointsAxonsOMP expressionOlfactory systemSequential maturationAxon development