Hypoxia and radiation therapy: past history, ongoing research, and future promise.
Rockwell S, Dobrucki IT, Kim EY, Marrison ST, Vu VT. Hypoxia and radiation therapy: past history, ongoing research, and future promise. 2009, 9: 442-58. PMID: 19519402, PMCID: PMC2752413, DOI: 10.2174/156652409788167087.Peer-Reviewed Original ResearchConceptsClinical trialsSolid tumorsLarge bulky tumorsMicroscopic tumor involvementSmall primary tumorsSelection of patientsOutcome of treatmentNovel therapeutic approachesNew therapeutic targetsEffects of hypoxiaHypoxic tumor cellsTumor oxygen levelsSurgical marginsTumor involvementBulky tumorsTreatment regimensPrimary tumorVascular bedClinical studiesExtensive necrosisRadiation therapyTherapeutic approachesNew agentsTherapeutic targetTherapeutic resistance