2024
Assessment of disparities in timely diagnosis and comprehensive workup of cognitive impairment between English and Spanish speakers
Silva-Rudberg J, Carrión C, Pérez-Palmer N, Li J, Mehta S, Diab N, Mecca A, O'Dell R. Assessment of disparities in timely diagnosis and comprehensive workup of cognitive impairment between English and Spanish speakers. American Journal Of Geriatric Psychiatry 2024, 32: 773-786. PMID: 38336573, PMCID: PMC11162952, DOI: 10.1016/j.jagp.2024.01.030.Peer-Reviewed Original ResearchDiagnosis of mild cognitive impairmentSpanish-speaking patientsMild cognitive impairmentHispanic/Latino patientsCognitive impairmentNon-English language preferenceLanguage preferenceComprehension of diagnosisImpact of language barriersAssessment of disparitiesDiagnosis of cognitive impairmentSpanish language preferenceDiagnosis of dementiaElectronic medical recordsCross-sectional studyTimeliness of diagnosisDementia careRetrospective cross-sectional studyDementia diagnosisHealth disparitiesU.S. Hispanic/Latino populationBinomial logistic regressionNeighborhood disadvantageSpanish speakersHealth care
2021
Association of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [11C]UCB-J
O’Dell R, Mecca AP, Chen MK, Naganawa M, Toyonaga T, Lu Y, Godek TA, Harris JE, Bartlett HH, Banks ER, Kominek VL, Zhao W, Nabulsi NB, Ropchan J, Ye Y, Vander Wyk BC, Huang Y, Arnsten AFT, Carson RE, van Dyck CH. Association of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [11C]UCB-J. Alzheimer's Research & Therapy 2021, 13: 11. PMID: 33402201, PMCID: PMC7786921, DOI: 10.1186/s13195-020-00742-y.Peer-Reviewed Original ResearchConceptsRegional Aβ depositionAβ depositionEarly Alzheimer's diseaseSynaptic lossSynaptic densityAlzheimer's diseaseDistribution volume ratioPositron emission tomographyHippocampal synaptic densityMild AD dementiaDeposition of AβSignificant inverse associationAmnestic mild cognitive impairmentWhole-brain analysisMild cognitive impairmentCerebellar reference regionPET imaging studiesPlaque burdenAD dementiaInverse associationPostmortem studiesClinical severityNeurodegenerative processesClinical diseaseLarge cohort