Robert Kalyesubula, MBChB
Assistant Professor AdjunctCards
About
Research
Publications
2024
Comparison of the prevalence and associated factors of chronic kidney disease diagnosed by serum creatinine or cystatin C among young people living with HIV in Uganda
Nasuuna E, Tomlinson L, Kalyesubula R, Dziva Chikwari C, Castelnuovo B, Manabe Y, Nakanjako D, Weiss H. Comparison of the prevalence and associated factors of chronic kidney disease diagnosed by serum creatinine or cystatin C among young people living with HIV in Uganda. BMC Nephrology 2024, 25: 422. PMID: 39587464, PMCID: PMC11590532, DOI: 10.1186/s12882-024-03865-8.Peer-Reviewed Original ResearchConceptsAlbumin-creatinine ratioChronic kidney diseaseFactors associated with chronic kidney diseaseSerum creatinineAdjusted odds ratiosCystatin CKidney diseaseEarly diagnosisAssociated with chronic kidney diseasePrevalence of chronic kidney diseaseCompare serum creatinineCreatinine-based onesFactors of chronic kidney diseaseAssociated with high mortalityCases of chronic kidney diseaseDefinition of chronic kidney diseaseChronic kidney disease prevalenceCystatin C-based equationsCystatin C levelsEstimate adjusted odds ratiosMeasuring urinary albuminConfidence intervalsDiagnosis of chronic kidney diseaseMultivariate logistic regressionReduce disease progressionPrevalence of chronic kidney disease among young people living with HIV in Sub Saharan Africa: A systematic review and meta-analysis
Nasuuna E, Nanyeenya N, Kibirige D, Izudi J, Chikwari C, Kalyesubula R, Castelnuovo B, Tomlinson L, Weiss H. Prevalence of chronic kidney disease among young people living with HIV in Sub Saharan Africa: A systematic review and meta-analysis. PLOS ONE 2024, 19: e0301954. PMID: 39495780, PMCID: PMC11534254, DOI: 10.1371/journal.pone.0301954.Peer-Reviewed Original ResearchConceptsPrevalence of chronic kidney diseaseChronic kidney disease prevalenceCKD prevalenceSub-Saharan AfricaDefinition of chronic kidney diseaseChronic kidney diseaseMeta-analysisPublication biasGlomerular filtration rateSystematic reviewJoanna Briggs Institute checklistEligibility criteriaI-squared valuePooled prevalence of chronic kidney diseaseEstimates of CKD prevalenceAlbumin-to-creatinine ratioDerSimonian-Laird random-effects modelCross-sectional studyRisk of biasAfrican Journals OnlineAfrican Index MedicusCochran's Q testRandom-effects modelStandard definitionYoung peopleGlobal Perspective on Acute Kidney Injury in Uganda.
Kansiime G, Langoya D, Kalyesubula R. Global Perspective on Acute Kidney Injury in Uganda. Kidney360 2024 PMID: 39378101, DOI: 10.34067/kid.0000000611.Peer-Reviewed Original ResearchA-058 Biomarkers of Nephropathy and the Angiotensin Converting Enzyme Insertion and Deletion Gene Polymorphisms Among Type 2 Diabetes Mellitus Patients at a Tertiary Hospital in Uganda
Kiconco R, Kalyesubula R, Kiwanuka G. A-058 Biomarkers of Nephropathy and the Angiotensin Converting Enzyme Insertion and Deletion Gene Polymorphisms Among Type 2 Diabetes Mellitus Patients at a Tertiary Hospital in Uganda. Clinical Chemistry 2024, 70: hvae106.057. DOI: 10.1093/clinchem/hvae106.057.Peer-Reviewed Original ResearchSerum glucose levelsType 2 diabetes mellitus patientsIncreased serum glucose levelsDecreased serum glucose levelsGlycated hemoglobinGlucose levelsGene polymorphismsTriglyceride levelsMellitus patientsDD genotypeAdult type 2 diabetes mellitus patientsPeripheral blood genomic DNAType 2 diabetic patientsMbarara Regional Referral HospitalACE II genotypeAngiotensin converting enzyme insertionACE DD genotypeMultivariate logistic regressionBlood genomic DNARegional Referral HospitalACE ID genotypeCross-sectional studyACE polymorphismReferral hospitalII genotypeHigher prevalence of kidney function impairment among older people living with HIV in Uganda
Ssemasaazi A, Kalyesubula R, Manabe Y, Mbabazi P, Naikooba S, Ssekindi F, Nasuuna E, Byakika-Kibwika P, Castelnuovo B. Higher prevalence of kidney function impairment among older people living with HIV in Uganda. BMC Nephrology 2024, 25: 321. PMID: 39334034, PMCID: PMC11428404, DOI: 10.1186/s12882-024-03761-1.Peer-Reviewed Original ResearchConceptsKidney function impairmentChronic kidney diseaseAntiretroviral therapyOlder PLWHFunctional impairmentKidney functionKidney diseaseHIV-related inflammationProgression of kidney diseasePrevalence of proteinuriaMultivariate logistic regression modelBurden of chronic kidney diseaseMeasures of kidney functionDiagnosis of hypertensionCross-sectional studyConclusionsHIV infectionHIV-related clinical characteristicsClinical characteristicsInstitution of measuresLogistic regression modelsDiabetes mellitusFemale sexHIVProteinuriaPLWHProteinuria as a Critical Indicator of Kidney Dysfunction in Type 2 Diabetes Patients: Insights From a Cross-Sectional Study
Kiconco R, Okoboi J, Mwesige S, Muwonge K, Kinobe R, Kalyesubula R, Kiwanuka G. Proteinuria as a Critical Indicator of Kidney Dysfunction in Type 2 Diabetes Patients: Insights From a Cross-Sectional Study. Cureus 2024, 16: e69946. PMID: 39445274, PMCID: PMC11496046, DOI: 10.7759/cureus.69946.Peer-Reviewed Original ResearchInternational equity in access to home dialysis
Iyengar A, Kalyesubula R, Darwish R, Luyckx V. International equity in access to home dialysis. Current Opinion In Nephrology & Hypertension 2024, 34: 112-120. PMID: 39282856, PMCID: PMC11608618, DOI: 10.1097/mnh.0000000000001027.Peer-Reviewed Original ResearchHome dialysisIn-centreMiddle-income countriesIn-centre haemodialysisDrivers of inequalityHealth systemLack of resourcesCommunity partnersPatient levelEquitable accessPeritoneal dialysisHomeHealthCliniciansGeopolitical levelNursesPatientsIn-centre dialysisAccessInequalityDoctorsLackDialysisReducing global inequalityCountriesDiagnostic performance of an albuminuria point-of-care test in screening for chronic kidney disease among young people living with HIV in Uganda: a cross-sectional study
Nasuuna E, Kalyesubula R, Tomlinson L, Castelnuovo B, Okello E, Chikwari C, Weiss H. Diagnostic performance of an albuminuria point-of-care test in screening for chronic kidney disease among young people living with HIV in Uganda: a cross-sectional study. BMJ Open 2024, 14: e083221. PMID: 39153770, PMCID: PMC11331864, DOI: 10.1136/bmjopen-2023-083221.Peer-Reviewed Original ResearchConceptsPositive POC testCross-sectional studyChronic kidney diseaseDiagnostic performancePoint-of-care testingKidney diseaseHIV clinicPOC testingPOC testsBody mass index <Albumin-creatinine ratioPositive predictive valueUrinary excretion rateDiagnosis of chronic kidney diseaseYoung peopleYears of ageTherapy to adultsYPLHIVUrine dipstickCreatinine ratioDiagnosis of albuminuriaLogistic regressionPrimary outcomeAlbuminuriaHIVIncidence of Acute Kidney Injury and Associated Mortality among Individuals with Drug-Susceptible Tuberculosis in Uganda
Kansiime G, Aklilu A, Baluku J, Yasmin F, Kanyesigye M, Muzoora C, Wilson F, Bajunirwe F, Brewster U, Kalyesubula R. Incidence of Acute Kidney Injury and Associated Mortality among Individuals with Drug-Susceptible Tuberculosis in Uganda. Kidney360 2024, 5: 1446-1454. PMID: 39141693, PMCID: PMC11556924, DOI: 10.34067/kid.0000000000000551.Peer-Reviewed Original ResearchIncidence of acute kidney injuryAcute kidney injuryDiagnosis periodKidney injuryKDIGO-defined acute kidney injuryKidney functionTB diagnosisPredictors of acute kidney injuryTime to TB diagnosisAssociated with significant risk of mortalityIndependent of HIV statusOverall incidence of AKIAssociated with increased mortality riskCohort study of adultsAssociated with higher oddsAssociated with significant mortalityDrug-susceptible TBDrug-susceptible tuberculosisObservational cohort study of adultsAssociated with significant riskHIV-negative participantsSignificant risk of mortalityObservational cohort studyStudy of adultsMonitoring kidney functionHealth-related quality of life and hypertension in people with HIV on long-term antiretroviral therapy in Uganda
Batte C, Semulimi A, Mukisa J, Nakabuye M, Nidoi J, Mukunya D, Ratanshi R, Castelnuovo B, Lamorde M, Meya D, Checkley W, Kalyesubula R, Siddharthan T, Babigumira J. Health-related quality of life and hypertension in people with HIV on long-term antiretroviral therapy in Uganda. PLOS ONE 2024, 19: e0306928. PMID: 39116145, PMCID: PMC11309503, DOI: 10.1371/journal.pone.0306928.Peer-Reviewed Original ResearchConceptsHealth-related quality of lifeHealth-related qualityQuality of lifeHRQoL scoresLong-term antiretroviral therapyAssociated with lower HRQoL scoresMedian health utility scorePhysical health scoresAntiretroviral therapyLower HRQOL scoresHealth utility scoresMedical Outcomes StudyEQ-5D-5LQuality-of-life assessmentManagement of PWHScores of peopleHealth scoresCompare HRQoLPlan early interventionsHRQoL dataHistory of smokingUrban clinicEQ-5DHRQoLUtility scores