Robert Kalyesubula, MBChB
Assistant Professor AdjunctCards
About
Research
Publications
2025
World Kidney Day: Detecting Kidney Disease in Low- and Middle-Income Countries
Wijewickrama E, Kalyesubula R. World Kidney Day: Detecting Kidney Disease in Low- and Middle-Income Countries. Kidney International Reports 2025, 10: 637-640. DOI: 10.1016/j.ekir.2025.01.016.Peer-Reviewed Original ResearchWCN25-2967 PREVALENCE, AWARENESS AND FACTORS ASSOCIATED WITH HYPERTENSION AMONG ADULTS IN RURAL SOUTH-WESTERN UGANDA: A CROSS-SECTIONAL STUDY
Kansiime G, Nuwagira E, Obwoya P, Baluku J, Kanyesigye M, Twesiime C, Ssebutunde C, Muhindo R, Muyingo A, Kananura K, Tusingwire P, Atukunda E, Kalyesubula R, Bajunirwe F, Muiru A. WCN25-2967 PREVALENCE, AWARENESS AND FACTORS ASSOCIATED WITH HYPERTENSION AMONG ADULTS IN RURAL SOUTH-WESTERN UGANDA: A CROSS-SECTIONAL STUDY. Kidney International Reports 2025, 10: s346. DOI: 10.1016/j.ekir.2024.11.640.Peer-Reviewed Original ResearchChronic kidney disease
Romagnani P, Agarwal R, Chan J, Levin A, Kalyesubula R, Karam S, Nangaku M, RodrÃguez-Iturbe B, Anders H. Chronic kidney disease. Nature Reviews Disease Primers 2025, 11: 8. PMID: 39885176, DOI: 10.1038/s41572-024-00589-9.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseKidney functionPresence of concomitant risk factorsRisk factorsSodium-glucose transporter 2Abnormalities of kidney functionConcomitant risk factorsManagement of patientsExcretory kidney functionKidney replacement therapyRenin-angiotensin systemModifiable risk factorsAssociated with accelerated cardiovascular diseaseSecondary hyperparathyroidismSequential injuryPersistent abnormalitiesReplacement therapySodium-glucoseCardiovascular morbidityMetabolic acidosisSevere infectionsCKD progressionKidney diseaseKidney failureTransporter 2Managing risk factors and early intervention for chronic kidney disease
Kalyesubula R, Luyckx V. Managing risk factors and early intervention for chronic kidney disease. Nature Reviews Nephrology 2025, 21: 149-150. PMID: 39814983, DOI: 10.1038/s41581-025-00930-9.Peer-Reviewed Original ResearchManagement of risk factorsImplementation of interventionsBurden of kidney diseaseGlobal burden of kidney diseaseRisk factorsManaging risk factorsQuality careKidney diseaseGlobal burdenEquitable accessPrevent disease progressionEarly interventionChronic kidney diseaseInterventionDisease progressionEarly diagnosis
2024
Comparison of the prevalence and associated factors of chronic kidney disease diagnosed by serum creatinine or cystatin C among young people living with HIV in Uganda
Nasuuna E, Tomlinson L, Kalyesubula R, Dziva Chikwari C, Castelnuovo B, Manabe Y, Nakanjako D, Weiss H. Comparison of the prevalence and associated factors of chronic kidney disease diagnosed by serum creatinine or cystatin C among young people living with HIV in Uganda. BMC Nephrology 2024, 25: 422. PMID: 39587464, PMCID: PMC11590532, DOI: 10.1186/s12882-024-03865-8.Peer-Reviewed Original ResearchConceptsAlbumin-creatinine ratioChronic kidney diseaseFactors associated with chronic kidney diseaseSerum creatinineAdjusted odds ratiosCystatin CKidney diseaseEarly diagnosisAssociated with chronic kidney diseasePrevalence of chronic kidney diseaseCompare serum creatinineCreatinine-based onesFactors of chronic kidney diseaseAssociated with high mortalityCases of chronic kidney diseaseDefinition of chronic kidney diseaseChronic kidney disease prevalenceCystatin C-based equationsCystatin C levelsEstimate adjusted odds ratiosMeasuring urinary albuminConfidence intervalsDiagnosis of chronic kidney diseaseMultivariate logistic regressionReduce disease progressionPrevalence of chronic kidney disease among young people living with HIV in Sub Saharan Africa: A systematic review and meta-analysis
Nasuuna E, Nanyeenya N, Kibirige D, Izudi J, Chikwari C, Kalyesubula R, Castelnuovo B, Tomlinson L, Weiss H. Prevalence of chronic kidney disease among young people living with HIV in Sub Saharan Africa: A systematic review and meta-analysis. PLOS ONE 2024, 19: e0301954. PMID: 39495780, PMCID: PMC11534254, DOI: 10.1371/journal.pone.0301954.Peer-Reviewed Original ResearchConceptsPrevalence of chronic kidney diseaseChronic kidney disease prevalenceCKD prevalenceSub-Saharan AfricaDefinition of chronic kidney diseaseChronic kidney diseaseMeta-analysisPublication biasGlomerular filtration rateSystematic reviewJoanna Briggs Institute checklistEligibility criteriaI-squared valuePooled prevalence of chronic kidney diseaseEstimates of CKD prevalenceAlbumin-to-creatinine ratioDerSimonian-Laird random-effects modelCross-sectional studyRisk of biasAfrican Journals OnlineAfrican Index MedicusCochran's Q testRandom-effects modelStandard definitionYoung peopleGlobal Perspective on Acute Kidney Injury in Uganda
Kansiime G, Langoya D, Kalyesubula R. Global Perspective on Acute Kidney Injury in Uganda. Kidney360 2024, 6: 152-155. PMID: 39378101, PMCID: PMC11793190, DOI: 10.34067/kid.0000000611.Peer-Reviewed Original ResearchA-058 Biomarkers of Nephropathy and the Angiotensin Converting Enzyme Insertion and Deletion Gene Polymorphisms Among Type 2 Diabetes Mellitus Patients at a Tertiary Hospital in Uganda
Kiconco R, Kalyesubula R, Kiwanuka G. A-058 Biomarkers of Nephropathy and the Angiotensin Converting Enzyme Insertion and Deletion Gene Polymorphisms Among Type 2 Diabetes Mellitus Patients at a Tertiary Hospital in Uganda. Clinical Chemistry 2024, 70: hvae106.057. DOI: 10.1093/clinchem/hvae106.057.Peer-Reviewed Original ResearchSerum glucose levelsType 2 diabetes mellitus patientsIncreased serum glucose levelsDecreased serum glucose levelsGlycated hemoglobinGlucose levelsGene polymorphismsTriglyceride levelsMellitus patientsDD genotypeAdult type 2 diabetes mellitus patientsPeripheral blood genomic DNAType 2 diabetic patientsMbarara Regional Referral HospitalACE II genotypeAngiotensin converting enzyme insertionACE DD genotypeMultivariate logistic regressionBlood genomic DNARegional Referral HospitalACE ID genotypeCross-sectional studyACE polymorphismReferral hospitalII genotypeHigher prevalence of kidney function impairment among older people living with HIV in Uganda
Ssemasaazi A, Kalyesubula R, Manabe Y, Mbabazi P, Naikooba S, Ssekindi F, Nasuuna E, Byakika-Kibwika P, Castelnuovo B. Higher prevalence of kidney function impairment among older people living with HIV in Uganda. BMC Nephrology 2024, 25: 321. PMID: 39334034, PMCID: PMC11428404, DOI: 10.1186/s12882-024-03761-1.Peer-Reviewed Original ResearchConceptsKidney function impairmentChronic kidney diseaseAntiretroviral therapyOlder PLWHFunctional impairmentKidney functionKidney diseaseHIV-related inflammationProgression of kidney diseasePrevalence of proteinuriaMultivariate logistic regression modelBurden of chronic kidney diseaseMeasures of kidney functionDiagnosis of hypertensionCross-sectional studyConclusionsHIV infectionHIV-related clinical characteristicsClinical characteristicsInstitution of measuresLogistic regression modelsDiabetes mellitusFemale sexHIVProteinuriaPLWHProteinuria as a Critical Indicator of Kidney Dysfunction in Type 2 Diabetes Patients: Insights From a Cross-Sectional Study
Kiconco R, Okoboi J, Mwesige S, Muwonge K, Kinobe R, Kalyesubula R, Kiwanuka G. Proteinuria as a Critical Indicator of Kidney Dysfunction in Type 2 Diabetes Patients: Insights From a Cross-Sectional Study. Cureus 2024, 16: e69946. PMID: 39445274, PMCID: PMC11496046, DOI: 10.7759/cureus.69946.Peer-Reviewed Original Research