2024
Genetic and non-genetic predictors of risk for opioid dependence.
Na P, Deak J, Kranzler H, Pietrzak R, Gelernter J. Genetic and non-genetic predictors of risk for opioid dependence. Psychological Medicine 2024, 54: 1779-1786. PMID: 38317430, PMCID: PMC11132928, DOI: 10.1017/s0033291723003732.Peer-Reviewed Original ResearchPolygenic risk scoresMulti-trait analysis of genome-wide association studyOpioid use disorderPosttraumatic stress disorderPsychosocial/environmental factorsAnalysis of genome-wide association studiesHigher education levelGenome-wide association studiesNon-genetic predictorsEuropean-ancestry adultsEtiology of ODPublic health crisisPsychosocial factorsPolygenic riskMulti-trait analysisEducation levelPsychosocial environmentHousehold incomeRisk scoreAssociation studiesOpioid dependenceDiagnosis of ODLifetime diagnosisYale-PennAssociated with OD
2022
Loneliness in U.S. military veterans during the COVID-19 pandemic: A nationally representative, prospective cohort study
Na PJ, Straus E, Tsai J, Norman SB, Southwick SM, Pietrzak RH. Loneliness in U.S. military veterans during the COVID-19 pandemic: A nationally representative, prospective cohort study. Journal Of Psychiatric Research 2022, 151: 546-553. PMID: 35636030, PMCID: PMC9126310, DOI: 10.1016/j.jpsychires.2022.05.042.Peer-Reviewed Original ResearchConceptsPrevalence of lonelinessPersistent lonelinessPandemic-related social restrictionsMultivariable logistic regression modelProtective factorsCOVID-19 pandemicPre-existing psychiatric conditionsProspective cohort studyMilitary veteransPre-pandemic measuresLogistic regression modelsProtective psychosocial factorsU.S. military veteransProspective cohortCohort studyUS veteransNational HealthHigh riskPsychiatric disordersPsychosocial factorsCOVID-related stressorsPsychiatric conditionsVeterans StudyLongitudinal changesVulnerable populations
2021
Psychosocial moderators of polygenic risk for suicidal ideation: Results from a 7-year population-based, prospective cohort study of U.S. veterans
Na PJ, De Angelis F, Nichter B, Wendt FR, Krystal JH, Southwick SM, Levey DF, Gelernter J, Polimanti R, Pietrzak RH. Psychosocial moderators of polygenic risk for suicidal ideation: Results from a 7-year population-based, prospective cohort study of U.S. veterans. Molecular Psychiatry 2021, 27: 1068-1074. PMID: 34725455, DOI: 10.1038/s41380-021-01352-2.Peer-Reviewed Original ResearchConceptsNew-onset suicidal ideationChronic suicidal ideationPolygenic risk scoresSuicidal ideationProspective cohort studyPolygenic riskRisk of SIHigher baseline levelsHigh polygenic riskModifiable psychosocial factorsSocial supportDispositional optimismCohort studyProspective cohortUS veteransSymptomatic courseRisk scorePsychosocial factorsGenome-wide association studiesBaseline levelsU.S. veteransSuicidal thoughtsPsychosocial moderatorsStudy periodLarge genome-wide association studies