Phillip Chan, MBChB, PhD, MRCP
Associate Research ScientistDownloadHi-Res Photo
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Neurology
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Associate Research Scientist
Biography
Dr Chan obtained his medical degree at the Chinese University of Hong Kong. He completed his fellowship training in internal medicine and neurology at the Queen Elizabeth Hospital of Hong Kong. Before joining the Yale School of Medicine, he served as a research fellow for NeuroHIV projects conducted in Bangkok, Thailand. He completed his PhD in neurological impacts of acute HIV infection at the University of Amsterdam in 2021. Between 2018 and 2022, he also worked with the Hong Kong University of Science and Technology on neurodegenerative disease research projects.
Last Updated on June 06, 2025.
Appointments
Neurology
Associate Research ScientistPrimary
Other Departments & Organizations
- Center for Brain & Mind Health
- Neurological Infections and Global Neurology
- Neurology
- Spudich Lab
Education & Training
- PhD
- University of Amsterdam (2021)
- Higher Physician Trainee (Advanced Internal Medicine)
- Queen Elizabeth Hospital
- Higher Physician Trainee (Neurology)
- Queen Elizabeth Hospital
- Basic Physician Trainee
- Queen Elizabeth Hospital
- MBChB
- The Chinese University of Hong Kong (2004)
Advanced Training & Certifications
- Membership of the Royal Colleges of Physicians (UK)
- Queen Elizabeth Hospital (2008)
Research
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Overview
Medical Research Interests
AIDS Dementia Complex; Biomarkers; Cerebrospinal Fluid; Neurocognitive Disorders; Neurodegenerative Diseases; Neuroimaging
Public Health Interests
Aging; HIV/AIDS; Infectious Diseases; Mental Health
ORCID
0000-0002-4071-4409
Research at a Glance
Yale Co-Authors
Frequent collaborators of Phillip Chan's published research.
Publications Timeline
A big-picture view of Phillip Chan's research output by year.
Research Interests
Research topics Phillip Chan is interested in exploring.
Serena Susan Spudich, MD, MA
Brinda Emu, MD
Mehran M Sadeghi, MD
Shelli Farhadian, MD, PhD
58Publications
785Citations
AIDS Dementia Complex
Biomarkers
Cerebrospinal Fluid
Neurocognitive Disorders
Neuroimaging
Publications
2025
Neuroaxonal Injury in Acute HIV Infection and Following Immediate Antiretroviral Therapy
Chan P, Sacdalan C, Pinyakorn S, Kroon E, Colby D, Promsena P, Sriplienchan S, Phanuphak N, Vasan S, Valcour V, Paul R, Gisslén M, Zetterberg H, Trautmann L, Spudich S. Neuroaxonal Injury in Acute HIV Infection and Following Immediate Antiretroviral Therapy. Journal Of Infectious Diseases 2025, jiaf583. PMID: 41254882, DOI: 10.1093/infdis/jiaf583.Peer-Reviewed Original ResearchAltmetricGreater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV
Holroyd K, Chan P, Sacdalan C, Dumrongpisutikul N, Sriplienchan S, Promensa P, Sailasuta P, Pothisri M, Puttamaswin S, Vasan S, Valcour V, Trautmann L, Spudich S, Paul R, Bolzenius J. Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV. Neurology 2025, 105: e214445. PMID: 41172230, DOI: 10.1212/wnl.0000000000214445.Peer-Reviewed Original ResearchBlood pressure and metabolic outcomes after efavirenz‐ or dolutegravir‐based therapy started in acute HIV infection
Chan P, Moreland S, Sacdalan C, Colby D, Ocampo F, Promsena P, Sriplienchan S, Wattana J, Intasan J, Phanuphak N, Vasan S, Paul R, Trautmann L, Spudich S, Kroon E, Team T. Blood pressure and metabolic outcomes after efavirenz‐ or dolutegravir‐based therapy started in acute HIV infection. HIV Medicine 2025, 26: 1619-1625. PMID: 41047593, DOI: 10.1111/hiv.70085.Peer-Reviewed Original ResearchAltmetricConceptsAcute HIV infectionBody mass indexAntiretroviral therapyLow-density lipoproteinTotal cholesterolBlood pressureHIV infectionWorld Health OrganizationLevels of plasma HIV RNACD8+ T cell countsPre-existing cardiovascular risk factorsWeeks 0Dolutegravir-based therapyPlasma HIV RNAT-cell countsAntiretroviral therapy regimensAntiretroviral therapy initiationAntiretroviral therapy guidelinesHigher Body Mass IndexLevels of total cholesterolDiastolic blood pressureCardiovascular risk factorsHigh-density lipoproteinFiebig stagesHIV RNAInside out: TNFa-RII and sexualized drug use in acute HIV predicts persistent depressive symptoms despite antiretroviral therapy
Chavez J, Bolzenius J, Chan P, Cho K, Mannarino J, Sacdalan C, Farhadian S, Trautmann L, Ndhlovu L, Tipsuk S, Crowell T, Krebs S, Slike B, Suttichom D, Colby D, Phanuphak N, Kroon E, Vasan S, Sriplienchan S, Spudich S, Paul R, Carrico A. Inside out: TNFa-RII and sexualized drug use in acute HIV predicts persistent depressive symptoms despite antiretroviral therapy. Brain Behavior & Immunity - Health 2025, 48: 101079. PMID: 40808976, PMCID: PMC12345309, DOI: 10.1016/j.bbih.2025.101079.Peer-Reviewed Original ResearchConceptsAcute HIV infectionAnti-retroviral therapySuppressive anti-retroviral therapyViral loadAdherence to anti-retroviral therapyDepressive symptom trajectoriesPlasma viral loadPersistent depressive symptomsDepressive symptomsSexualized drug useAcute HIVAntiretroviral therapyLong-term neuropsychiatric consequencesHIV infectionPathophysiological alterationsDepressive disorderQuality of lifeSymptom trajectoriesDrug useOverall quality of lifeNeuropsychiatric consequencesLogistic regressionNitrite useReduced riskSymptomsCROI 2025: neuropsychiatric complications in people with HIV.
. CROI 2025: neuropsychiatric complications in people with HIV. Topics In Antiviral Medicine 2025, 33: 483-493. PMID: 40472384.Peer-Reviewed Original ResearchGreater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV
Holroyd K, Chan P, Sacdalan C, Dumrongpisutikul N, Sriplienchan S, Promensa P, Sailasuta P, Pothisri M, Puttamaswin S, Vasan S, Valcour V, Trautmann L, Spudich S, Paul R, Bolenzius J, Team A. Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV. Neurology 2025, 104: e213591. PMID: 40327828, PMCID: PMC12060792, DOI: 10.1212/wnl.0000000000213591.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAcute HIV infectionAntiretroviral therapyWhite matter hyperintensitiesWMH changeViral suppressionHIV infectionBaseline CD4+ T-cell countVascular comorbiditiesCD4+ T-cell countIncreased rate of ischemic strokeUndetectable plasma viral loadT2-fluid-attenuated inversion recovery sequencesPlasma viral loadT-cell countsAntiretroviral therapy initiationEarly ART initiationFluid-attenuated inversion recovery sequencesBrain white matter hyperintensityHistory of psychiatric disordersFollow-up periodRate of ischemic strokeRepeated-measures ANOVAIncreased risk of strokeTwo-year follow-upExposure to HIVCognitive Trajectories 1 Year Before and After COVID-19 in an Early-Treated HIV Cohort (S19.005)
Ocampo F, Hamby T, Poonpitak L, Sacdalan C, Sriplienchan S, Phanuphak N, Chan P, Crowell T, Trautmann L, Vasan S, Paul R, Spudich S. Cognitive Trajectories 1 Year Before and After COVID-19 in an Early-Treated HIV Cohort (S19.005). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000208417.Peer-Reviewed Original ResearchLongitudinal CNS and systemic T-lymphocyte and monocyte activation before and after antiretroviral therapy beginning in primary HIV infection
Chan P, Li X, Li F, Emu B, Price R, Spudich S. Longitudinal CNS and systemic T-lymphocyte and monocyte activation before and after antiretroviral therapy beginning in primary HIV infection. Frontiers In Immunology 2025, 16: 1531828. PMID: 40070827, PMCID: PMC11893981, DOI: 10.3389/fimmu.2025.1531828.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCerebrospinal fluid HIV RNAPrimary HIV infectionT cell activationCD8+ T cell activationAntiretroviral therapyHIV RNACD4+HIV infectionCerebrospinal fluidT cellsMonocyte activationNeuronal injuryCD4+ T cell activationCD8+ T cellsCD8+ T cellsFrequencies of activated CD4+ART-naive peopleChronic HIV infectionTrafficking of immune cellsAntiretroviral therapy initiationChemokine receptor expressionMultiparameter flow cytometryImmune cell activationSurface marker expressionCentral nervous systemNeuropsychiatric and laboratory outcomes of hepatitis C treatment in an early-treated HIV cohort in Thailand
Ocampo F, Sacdalan C, Pinyakorn S, Paudel M, Wansom T, Poltubtim N, Sriplienchan S, Phanuphak N, Paul R, Hsu D, Colby D, Trautmann L, Spudich S, Chan P. Neuropsychiatric and laboratory outcomes of hepatitis C treatment in an early-treated HIV cohort in Thailand. AIDS Research And Therapy 2025, 22: 20. PMID: 39972347, PMCID: PMC11841302, DOI: 10.1186/s12981-025-00707-x.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsWeeks of antiretroviral therapyAcute HIV infectionT-cell countsT cell ratioAntiretroviral therapyPatient Health Questionnaire-9HCV seroconversionDAA treatmentCD4 + and CD8 + T cell countsCD4+ /CD8+ T-cell ratioCD8+ T cell countsDirect-acting antiviral (DAA) therapyAlanine transaminaseCD4+ /CD8+ ratioAspartate transferaseIntravenous drug useEarly HCV infectionSexually transmitted infectionsFollow-up visitPatient Health Questionnaire-9 scoresBackgroundHepatitis C virusHepatitis C treatmentHIV RNAVirological responseDAA therapyImpaired creatinine-based estimated glomerular filtration rate in Thai individuals switching to dolutegravir: illustrating the role of cystatin C testing to aid clinical decision making
. Impaired creatinine-based estimated glomerular filtration rate in Thai individuals switching to dolutegravir: illustrating the role of cystatin C testing to aid clinical decision making. AIDS Research And Therapy 2025, 22: 15. PMID: 39920714, PMCID: PMC11804080, DOI: 10.1186/s12981-025-00712-0.Peer-Reviewed Original ResearchCitations
Clinical Trials
Current Trials
Volunteers Needed for HIV & Health Study (HARC Plus)
HIC ID1502015318RoleSub InvestigatorPrimary Completion Date06/01/2025Recruiting Participants
Academic Achievements & Community Involvement
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Activities
activity Scientific Committee, Asia Pacific AIDS & Co-infections Conference (APACC)
2019 - PresentPeer Review Groups and Grant Study SectionsAbstract Graderactivity International AIDS Society (IAS) Conference on HIV Science
2022 - PresentPeer Review Groups and Grant Study SectionsAbstract Graderactivity Royal Colleges of Physicians (UK)
2008 - PresentProfessional OrganizationsMemberactivity Hong Kong College of Physicians (Neurology)
2011 - PresentProfessional OrganizationsFellowactivity Hong Kong Academy of Medicine (Medicine)
2012 - PresentProfessional OrganizationsFellow
Honors
honor Patterson Trust Mentored Research Award
01/31/2023Regional AwardDetailsUnited Stateshonor Research Fund 2019-20, the Hong Kong Neurological Society
01/07/2020Regional AwardThe Hong Kong Neurological SocietyDetailsHong Konghonor Young Fellowship Program
06/27/2019International AwardAsia Pacific AIDS & Co-infections Conference (APACC)DetailsThailandhonor Young Investigator Scholarship
02/13/2017Other AwardConference on Retroviruses and Opportunistic Infections (CROI) 2017DetailsUnited States
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