Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsNicolas Gaspard, PhD
Assistant Professor AdjunctAbout
Research
Publications
2025
Features, Outcome, and Treatment of Postanoxic Status Epilepticus
De Stefano P, Hofmeijer J, Quintard H, Damien C, Misirocchi F, Caroyer S, Horn J, Tromp S, Kornips B, Hilkman D, van Mook W, Hoedemaekers C, Annoni F, Legros B, Seeck M, Van Putten M, Gaspard N, investigators F. Features, Outcome, and Treatment of Postanoxic Status Epilepticus. Neurology 2025, 105: e214282. PMID: 40982774, DOI: 10.1212/wnl.0000000000214282.Peer-Reviewed Original ResearchQuality of life over time after new onset refractory status epilepticus
Gruen M, Gopaul M, Jimenez A, Batra A, Blank L, Damien C, Day G, Eschbach K, Gerard E, Gofton T, Hantus S, Jette N, Jongeling A, Kang P, Kazazian K, Kellogg M, Kim M, Madani B, Morales M, Punia V, Steriade C, Struck A, Taraschenko O, Torcida N, Wainwright M, Yoo J, Gaspard N, Wong N, Hirsch L, Hanin A. Quality of life over time after new onset refractory status epilepticus. Epilepsia 2025 PMID: 40944696, DOI: 10.1111/epi.18635.Peer-Reviewed Original ResearchQuality of lifeAssociations with poor quality of lifePoor quality of lifeMeasures of fatigueQoL-ISocial support strategiesReference populationAssociated with more depressionQuality of life improvementMultidisciplinary support systemQuality of life impairmentNeuro-QoLPerceived stigmaMulticenter prospective studySocial healthSocial rolesSupport strategiesPediatric participantsIntensive care unit stayCognitive difficultiesCognitive impairmentGreater improvementAcute episodeT-scoreAdultsStandard complete blood count to predict long‐term outcomes in febrile infection–related epilepsy syndrome (FIRES): A multicenter study
Guillemaud M, Hanin A, Riviello J, Chavez M, Batra A, Berry M, Bisulli F, Castillo‐Pinto C, Cobos‐Hernandez C, Demeret S, Eschbach K, Farias‐Moeller R, Fields M, Gaspard N, Gerard E, Gofton T, Gopaul M, Gruen M, Jimenez A, Kazazian K, Kim M, Mansour M, Marcuse L, Marois C, Morales M, Muccioli L, Pasini E, Pham M, Rosas S, Struck A, Torcida N, Wainwright M, Yoo J, Muscal E, Navarro V, Hirsch L, Lai Y. Standard complete blood count to predict long‐term outcomes in febrile infection–related epilepsy syndrome (FIRES): A multicenter study. Epilepsia 2025 PMID: 40844418, DOI: 10.1111/epi.18605.Peer-Reviewed Original ResearchFebrile infection-related epilepsy syndromeMonocyte-to-lymphocyte ratioNeutrophil-to-lymphocyte ratioComplete blood countNew-onset refractory status epilepticusSecond-line immunotherapyUnfavorable outcomeBlood countComplete blood count levelsHigh red cell distribution widthEpilepsy syndromesTreatment phaseFirst-line immunotherapyInitiation of immunotherapyRed cell distribution widthRefractory status epilepticusComplete blood count dataCell distribution widthLong-term outcomesIntensive care unitSubtypes of leukocytesLeave-one-patient-outMulticenter studyStatus epilepticusImmunotherapyFeatures, Outcome, and Treatment of Postanoxic Status Epilepticus
De Stefano P, Hofmeijer J, Quintard H, Damien C, Misirocchi F, Caroyer S, Horn J, Tromp S, Kornips B, Hilkman D, van Mook W, Hoedemaekers C, Annoni F, Legros B, Seeck M, Van Putten M, Gaspard N, investigators F, Ruijter B, Keijzer H, Tjepkema-Cloostermans M, Blans M, Bosch F, Glimmerveen A, Beishuisen A, Eertman C, Tromp S, Scholten E, Seeber A, Teunissen L, Datema M, Noordzij P, Moeniralam H, Horn J, van Rootselaar A, Admiraal M, Velseboer D, Koelman J, van den Bergh W, Elting J, Drost G, Foudraine N, Kornips F, van Kranen-Mastenbroek V, Rouhl R, Hilkman D, Aries M, van Mook W, Vlooswijk M, Thomeer E, Moudrous W, Nijhuis F, Booij S, Bernsen H, Hoedemaekers C, Doorduin J, Taccone F, Gaspard N, van der Palen J, van Putten M, Hofmeijer J. Features, Outcome, and Treatment of Postanoxic Status Epilepticus. Neurology 2025, 105: e213913. PMID: 40720710, PMCID: PMC12296630, DOI: 10.1212/wnl.0000000000213913.Peer-Reviewed Original ResearchConceptsMulticenter pooled analysisStatus epilepticusCerebral Performance CategoryCardiac arrestGood outcomeSE cessationSE onsetHigh dosesHigher dose of levetiracetamMultivariate analysisPooled analysis of individual patient dataAnalysis of individual patient dataEEG predictorsAssociated with favorable outcomesPostanoxic status epilepticusAssociated with good recoveryDose of levetiracetamExclusion of patientsGroup of patientsIdentification of patientsPredictors of outcomeIndividual patient dataPrognostic significanceSE patientsCardiopulmonary resuscitation trialsThe SEDS score: A daily severity score for monitoring patients with refractory SE in the ICU
Damien C, Habryka S, Torcida N, Wang L, Legros B, Yuan F, Gaspard N. The SEDS score: A daily severity score for monitoring patients with refractory SE in the ICU. Seizure 2025, 131: 344-350. PMID: 40811895, DOI: 10.1016/j.seizure.2025.07.011.Peer-Reviewed Original ResearchConceptsRefractory status epilepticusWeek of intensive care unitArea under the receiver operating characteristic curveIntensive care unitSequential Organ Failure AssessmentIntensive care unit admissionDaily severity scoreValidation cohortDerivation cohortRSE episodesSeverity scoreSequential Organ Failure Assessment scoreOrgan Failure AssessmentTertiary-care centerRetrospective observational studyReceiver operating characteristic curveC-reactive proteinMann-Whitney testOperating characteristics curveRefractory SEPrognostic scoreSOFA scoreCRP levelsStatus epilepticusPoor outcomeThe Role of Electroencephalography in Predicting Post‐Stroke Seizures and an Updated Prognostic Model (SeLECT‐EEG)
Schubert K, Dasari V, Oliveira A, Tatillo C, Naeije G, Strzelczyk A, Merlino G, Valente M, Gaspard N, Punia V, Galovic M, Bentes C, Collaborators F. The Role of Electroencephalography in Predicting Post‐Stroke Seizures and an Updated Prognostic Model (SeLECT‐EEG). Annals Of Neurology 2025 PMID: 40568812, DOI: 10.1002/ana.27301.Peer-Reviewed Original ResearchAcute symptomatic seizuresSymptomatic seizuresEarly electroencephalographyEpileptiform activityPost-stroke epilepsyRegional slowingEpilepsy riskRisk factorsCox proportional hazards regressionMulticenter cohort studyClinical risk factorsEarly risk stratificationAssociated with post-stroke epilepsyProportional hazards regressionFine-Gray subdistribution hazard modelPredictors of post-stroke epilepsyRisk stratificationCohort studyPatient characteristicsPatient counselingPatient managementSubdistribution hazard modelHazards regressionPost-stroke seizuresPatientsPatients with status epilepticus and new‐onset refractory status epilepticus display drastically altered fecal microbiomes compared to chronic epilepsy patients
Steriade C, Thomas S, Xu F, Ahituv A, Hanin A, Pleshkevich M, Hwang S, Ramirez A, Foreman B, Yoo J, Eka O, Kellogg M, Oliger A, Wainwright M, Morales M, Gaspard N, Hirsch L, Devinsky O, Saxena D. Patients with status epilepticus and new‐onset refractory status epilepticus display drastically altered fecal microbiomes compared to chronic epilepsy patients. Epilepsia 2025, 66: 3254-3268. PMID: 40387216, DOI: 10.1111/epi.18450.Peer-Reviewed Original ResearchChronic epilepsy patientsSE patientsStatus epilepticusEpilepsy patientsChronic epilepsyPre-existing epilepsyFuture treatment strategiesDisease time pointsInflammatory cytokine levelsFecal microbiomeMicrobiome structureLongitudinal cohort studyMicrobiome featuresCytokine levelsEffective therapyCohort studyTreatment strategiesInflammatory cytokinesSE resolutionInflammatory responseCritical illnessPatientsGut dysbiosisMortality rateClinical treatmentIdentification of Distinct Biological Groups of Patients With Cryptogenic NORSE via Inflammatory Profiling
Guillemaud M, Chavez M, Kobeissy F, Vezzani A, Jimenez A, Basha M, Batra A, Demeret S, Eka O, Eschbach K, Foreman B, Gaspard N, Gerard E, Gofton T, Haider H, Hantus S, Howe C, Jongeling A, Kalkach-Aparicio M, Kandula P, Kazazian K, Kim M, Lai Y, Marois C, Mellor A, Mohamed W, Morales M, Pimentel C, Ramirez A, Steriade C, Struck A, Taraschenko O, Torcida Sedano N, Wainwright M, Yoo J, Wang K, Navarro V, Hirsch L, Hanin A. Identification of Distinct Biological Groups of Patients With Cryptogenic NORSE via Inflammatory Profiling. Neurology Neuroimmunology & Neuroinflammation 2025, 12: e200403. PMID: 40334176, PMCID: PMC12063244, DOI: 10.1212/nxi.0000000000200403.Peer-Reviewed Original ResearchConceptsCryptogenic new-onset refractory status epilepticusClusters of patientsCytokine profileInflammatory markersNew-onset refractory status epilepticusTarget specific inflammatory pathwaysInitiation of immunotherapyResponse to immunotherapyRefractory status epilepticusPersonalized therapeutic strategiesGroup of patientsStatistically significant elevationTime of administrationProtein pathway analysisInflammatory subgroupsMultiple immunotherapiesDifferential treatment responseRefractory SEC patientsImprove patient outcomesAutoimmune mechanismsImmune dysregulationClinical featuresCytokine levelsAutoimmune processOn‐scalp magnetoencephalography based on optically pumped magnetometers to investigate temporal lobe epilepsy
Feys O, Wens V, Depondt C, Rikir E, Gaspard N, Van Paesschen W, Aeby A, Bodart O, Carrette E, Holmes N, Brookes M, Ferez M, Corvilain P, De Tiège X. On‐scalp magnetoencephalography based on optically pumped magnetometers to investigate temporal lobe epilepsy. Epilepsia 2025, 66: e142-e151. PMID: 40317508, DOI: 10.1111/epi.18439.Peer-Reviewed Original ResearchInterictal epileptiform dischargesOptically pumped magnetometersTemporal lobe epilepsyOn-scalp magnetoencephalographyLobe epilepsyRefractory temporal lobe epilepsySignal-to-noise ratioInvestigate temporal lobe epilepsySurgical resection cavityExtratemporal lobe epilepsyOn-scalpResection cavityEpileptiform dischargesPatientsEpilepsyTemporal lobeMEG recordingsMagnetoencephalographyMagnetometerAmplitudeFeatures affecting treatment decisions and outcome in refractory status epilepticus
Damien C, Sedano N, Depondt C, Legros B, Gaspard N. Features affecting treatment decisions and outcome in refractory status epilepticus. Epilepsia 2025, 66: 2779-2789. PMID: 40261726, DOI: 10.1111/epi.18423.Peer-Reviewed Original ResearchConceptsThird-line treatmentRefractory status epilepticusStatus epilepticusAssociated with mortalityGlasgow Coma ScaleRSE episodesRisk factorsAssociated with worse outcomesRefractory convulsive SERisk factors of mortalityGlasgow Coma Scale scoreOutcome measuresFactors of mortalityIn-Hospital MortalityHistory of epilepsyAssociated with outcomePrimary outcome measureSecondary outcome measuresConsecutive patientsConvulsive SENonconvulsive SESE onsetTertiary centerAcute etiologySingle-center