Skip to Main Content

INFORMATION FOR

    Nicholas Blondin, MD

    Associate Professor
    DownloadHi-Res Photo

    Are You a Patient?

    View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.

    View Doctor Profile

    Additional Titles

    Neuro-Oncology Clinical Research Team Leader, Medical Oncology

    Contact Info

    Yale Cancer Center

    Smilow Trumbull Care Center, 5520 Park Avenue

    Trumbull, CT 06611

    United States

    About

    Titles

    Associate Professor

    Neuro-Oncology Clinical Research Team Leader, Medical Oncology

    Biography

    Nicholas A. Blondin, MD, is an Associate Professor of Neurology at Yale School of Medicine. Dr. Blondin cares for patients at Smilow Cancer Hospital in New Haven and the Smilow Cancer Hospital Cancer Care Center in Trumbull. He received his Medical Degree from the University of Connecticut School of Medicine and completed his neurology residency at Yale New Haven Hospital, where he was Chief Resident in Neurology, followed by a fellowship in Neuro-Oncology at Yale New Haven Hospital. Before joining Smilow, he was the Director of the Neuro-Oncology Program at Associated Neurologists of Southern CT and the Medical Director of the St. Vincent’s Brain Tumor Center. Watch a video with Dr. Nicholas Blondin>>

    Dr. Blondin’s clinical expertise is in treating benign and malignant brain tumors, brain and spine metastasis, and neurological symptoms of cancer, such as seizures, cognitive impairment, headaches, gait disturbance, and weakness. He has a particular interest in treating glioblastoma, IDH-mutant glioma, and leptomeningeal metastasis of cancer.

    Dr. Blondin is the leader of the Neuro-Oncology Clinical Research Team, and serves as Principal Investigator of clinical trials at Yale and nationally. He is a member of the Developmental Therapeutics section of the Yale Cancer Center. He also is a member of the Yale Biomedical Imaging Institute and is the Clinical Principal Investigator for studies of Deuterium Metabolic Imaging of brain tumors.

    Last Updated on November 13, 2025.

    Appointments

    Education & Training

    Neuro-Oncology Fellow
    Yale University (2013)
    Chief Resident
    Yale School of Medicine (2012)
    Resident
    Yale School of Medicine (2011)
    Intern
    Yale School of Medicine (2009)
    MD
    University of Connecticut School of Medicine
    BA
    Wesleyan University, Chemistry

    Research

    Overview

    Dr. Blondin is the leader of the Yale Neuro-Oncology Clinical Research Team (CRT). In this role, he oversees the research team conducting clinical trials at Yale. Dr. Blondin serves as Principal Investigator in studies of glioblastoma, IDH-mutant glioma (astrocytoma), meningioma, and brain metastasis. Dr. Blondin is a member of the GBM AGILE Leadership Council and is the National co-PI of the ADI-PEG20 investigational arm.

    Dr. Blondin is a member of the Yale Biomedical Imaging Institute, and is the Clinical Principal Investigator of the Deuterium Metabolic Imaging (DMI) project at Yale.

    Dr. Blondin is studying the mechanisms of glioblastoma resistance to cancer-directed therapies, and is building a neuro-oncology "Brain Bank" of autopsy tissue donations.

    Medical Research Interests

    Astrocytoma; Glioblastoma; Meningioma

    Public Health Interests

    Clinical Trials; Cancer

    Research at a Glance

    Yale Co-Authors

    Frequent collaborators of Nicholas Blondin's published research.

    Publications

    2025

    2024

    2023

    Clinical Trials

    Academic Achievements & Community Involvement

    Activities

    • activity

      Yale University Protocol Review Committee (PRC)

    • activity

      National Brain Tumor Society

    • activity

      Society for Neuro-Oncology

    • activity

      Connecticut Brain Tumor Alliance

    • activity

      Musella Foundation

    Honors

    • honor

      Connecticut Brain Tumor Alliance Humanitarian Award

    • honor

      Cigna Care Designation

    • honor

      UnitedHealth Premium Designation, Quality & Cost Efficiency

    • honor

      Palatucci Advocacy Leadership Forum Graduate

    • honor

      Gold Humanism Honor Society

    Teaching & Mentoring

    Teaching

    • Clinical

      MD 2025: MAP Neurology Component

      LecturerInpatient Clinical Setting

    Clinical Care

    Overview

    Nicholas A. Blondin, MD, is a Yale Medicine neurologist who specializes in treating benign (noncancerous) and malignant (cancerous) brain tumors, brain and spine metastasis, and neurological symptoms of cancer such as seizures, cognitive impairment, headaches, gait disturbance, and weakness. He cares for patients at Smilow Cancer Hospital in New Haven and the Smilow Cancer Hospital Cancer Care Center in Trumbull.

    “I love developing a strong doctor-patient relationship with my patients,” Dr. Blondin says. “I believe that a strong, trusting relationship is critical for me to help patients achieve their treatment goals and have the best possible quality of life.”

    Dr. Blondin believes in “shared decision making,” a process he uses to create a treatment plan that will be best for each patient. “With a difficult diagnosis, I am open and honest but also work to provide hope that treatment will be effective,” Dr. Blondin says. “I let patients know that I will always be there for them, and I will support them in all phases of treatment.”

    Together with a team of doctors at Smilow, he is able to help more patients achieve better outcomes. “In neuro-oncology, I rely on additional specialists such as neurosurgeons, radiation oncologists, pathologist, and neuro-radiologists in order to provide the best care for my patients,” he says.

    Dr. Blondin is an active investigator for clinical trials for brain tumor patients through Yale Cancer Center and is an associate professor of neurology at Yale School of Medicine.

    Clinical Specialties

    Neuro-Oncology; Neurology

    Fact Sheets

    Board Certifications

    • Neuro-Oncology

      Certification Organization
      United Council for Neurologic Subspecialties
      Latest Certification Date
      2022
      Original Certification Date
      2015
    • Neurology

      Certification Organization
      AB of Psychiatry & Neurology
      Original Certification Date
      2012

    Yale Medicine News

    Get In Touch

    Contacts

    Appointment Number
    Clinical Inquiry Number
    Clinic Fax Number
    Mailing Address

    Yale Cancer Center

    Smilow Trumbull Care Center, 5520 Park Avenue

    Trumbull, CT 06611

    United States

    Administrative Support

    Locations

    • Neuro-Oncology

      Academic Office

      Lippard Laboratory of Clinical Investigation (LLCI)

      15 York Street

      New Haven, CT 06510

      Business Office

      203.737.7084
    • Patient Care Locations

      Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.