Featured Publications
Proximal fate marker homothorax marks the lateral extension of stalk‐eyed fly Cyrtodopsis whitei
Singh A, Gogia N, Chang C, Sun YH. Proximal fate marker homothorax marks the lateral extension of stalk‐eyed fly Cyrtodopsis whitei. Genesis 2019, 57: e23309. PMID: 31162816, PMCID: PMC6744308, DOI: 10.1002/dvg.23309.Peer-Reviewed Original ResearchConceptsStalk-eyed fliesImaginal discsEye-antennal imaginal discCompound eyeEye imaginal discImportant evolutionary traitAdult compound eyesProximo-distal axisProximal fateEvolutionary traitsSpecific fatesDiptera orderExpression evolvesFamily DiopsidaeInsect headHth expressionDistal fatesAntennal segmentsFliesHomothoraxInsectsAdult eyesWhiteiFatePhenotypeA soy protein Lunasin can ameliorate amyloid-beta 42 mediated neurodegeneration in Drosophila eye
Sarkar A, Gogia N, Glenn N, Singh A, Jones G, Powers N, Srivastava A, Kango-Singh M, Singh A. A soy protein Lunasin can ameliorate amyloid-beta 42 mediated neurodegeneration in Drosophila eye. Scientific Reports 2018, 8: 13545. PMID: 30202077, PMCID: PMC6131139, DOI: 10.1038/s41598-018-31787-7.Peer-Reviewed Original ResearchConceptsRetinal neuronsNeuroprotective roleAlzheimer's diseaseHuman Aβ42Fatal progressive neurodegenerative disorderNovel neuroprotective roleProgressive neurodegenerative disorderAnti-cancer effectsPotential therapeutic agentJNK signalingAβ42 plaquesNeuronal deathNeuroprotective functionMortality rateTransgenic modelAxonal targetingNeurodegenerative disordersTherapeutic agentsCJun N-terminal kinaseNeurodegenerationOxidative stressAβ42NeuronsAbnormal signalingLunasinCharacterization of a morphogenetic furrow specific Gal4 driver in the developing Drosophila eye
Sarkar A, Gogia N, Farley K, Payton L, Singh A. Characterization of a morphogenetic furrow specific Gal4 driver in the developing Drosophila eye. PLOS ONE 2018, 13: e0196365. PMID: 29702674, PMCID: PMC5922546, DOI: 10.1371/journal.pone.0196365.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedBody PatterningCell DifferentiationDrosophila melanogasterDrosophila ProteinsGene Expression ProfilingGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsImmunohistochemistryIntracellular Signaling Peptides and ProteinsNuclear ProteinsPhenotypeProtein Serine-Threonine KinasesRetinaRetinal NeuronsTrans-ActivatorsTranscription FactorsTransforming Growth Factor betaWnt1 ProteinYAP-Signaling Proteins
2024
Genetic mechanism regulating diversity in the placement of eyes on the head of animals
Puli O, Gogia N, Chimata A, Yorimitsu T, Nakagoshi H, Kango-Singh M, Singh A. Genetic mechanism regulating diversity in the placement of eyes on the head of animals. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2316244121. PMID: 38588419, PMCID: PMC11032433, DOI: 10.1073/pnas.2316244121.Peer-Reviewed Original ResearchConceptsMorphogen gradientsCell fateRegulate Wg signalingEye developmentGradients of signaling moleculesHomeodomain transcription factorRetinal determination genesWg signalingWnt/Wg signalingGain-of-functionWg expressionEye fateDefective proventriculusDetermination genesEye genesGenetic machineryTranscription factorsRetinal cell fateDevelopmental defectsPatterning cuesMorphogenGenesHead vertexFacial anomaliesFate
2015
Drosophila Eye Model to Study Neuroprotective Role of CREB Binding Protein (CBP) in Alzheimer’s Disease
Cutler T, Sarkar A, Moran M, Steffensmeier A, Puli OR, Mancini G, Tare M, Gogia N, Singh A. Drosophila Eye Model to Study Neuroprotective Role of CREB Binding Protein (CBP) in Alzheimer’s Disease. PLOS ONE 2015, 10: e0137691. PMID: 26367392, PMCID: PMC4569556, DOI: 10.1371/journal.pone.0137691.Peer-Reviewed Original ResearchConceptsCREB Binding ProteinTargeted misexpressionCBP proteinGAL4/UAS systemBinding proteinGenetic modifiersDrosophila eye modelNormal cellular processesTargeting of axonsFruit fly modelStructure-function analysisAmyloid precursor proteinProgressive neurodegenerative phenotypeTransgenic fliesCellular processesPolyglutamine domainHistone acetylaseNeuroprotective functionPhotoreceptor neuronsFly modelGenetic basisUAS systemAmyloid plaquesMisexpressionDifferent proteins