Chapter 11 Role of AMP-activated protein kinase and sirtuins as antiaging proteins
Ramu M, Vishal S, Gogia N. Chapter 11 Role of AMP-activated protein kinase and sirtuins as antiaging proteins. 2022, 241-278. DOI: 10.1016/b978-0-323-90235-9.00015-x.ChaptersProtein kinaseAMP/ATP ratioDifferent cellular compartmentsCommon cellular targetActivity of AMPKFuel-sensing enzymeAge-associated disordersChapter 11 RoleSirtuin isoformsCellular compartmentsAge-related disordersSirtuin modulatorsSirtuin activityDifferent speciesAMPKCellular targetsAMPK pathwayContext of agingMitochondrial functionMitochondrial disordersPotential therapeutic targetATP ratioAge-related processesKinaseSIRT1Exploring the efficacy of natural products in alleviating Alzheimer’s disease
Deshpande P, Gogia N, Singh A. Exploring the efficacy of natural products in alleviating Alzheimer’s disease. Neural Regeneration Research 2019, 14: 1321-1329. PMID: 30964049, PMCID: PMC6524497, DOI: 10.4103/1673-5374.253509.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPotential therapeutic targetAnimal model systemsTherapeutic targetAlzheimer's diseaseNeurodegenerative disordersOnset of ADProgressive neurodegenerative disorderCentral nervous systemClinical trialsTau tanglesDirect cureSide effectsNervous systemCognitive defectsDiseaseMitochondrial dysfunctionReactive oxygen speciesGenetic mutationsAberrant signalingSpecific diseasesPsychological problemsCell deathPlaquesDisordersOxygen species