Hippo signaling: bridging the gap between cancer and neurodegenerative disorders
Gogia N, Chimata AV, Deshpande P, Singh A, Singh A. Hippo signaling: bridging the gap between cancer and neurodegenerative disorders. Neural Regeneration Research 2020, 16: 643-652. PMID: 33063715, PMCID: PMC8067938, DOI: 10.4103/1673-5374.295273.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCell deathHippo pathwayGrowth regulationAberrant cell deathRole of HippoNeurodegenerative disordersCell proliferationCell death mechanismsCell death resultsOrgan sizeDeath mechanismsNeuronal cell populationsChemical inhibitorsHippoNormal developmentVariety of mechanismsFundamental processesCell proliferation resultsCell populationsPathwayVariety of diseasesNeurodegenerative diseasesRegulationDeath resultsProliferation resultsExploring the efficacy of natural products in alleviating Alzheimer’s disease
Deshpande P, Gogia N, Singh A. Exploring the efficacy of natural products in alleviating Alzheimer’s disease. Neural Regeneration Research 2019, 14: 1321-1329. PMID: 30964049, PMCID: PMC6524497, DOI: 10.4103/1673-5374.253509.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPotential therapeutic targetAnimal model systemsTherapeutic targetAlzheimer's diseaseNeurodegenerative disordersOnset of ADProgressive neurodegenerative disorderCentral nervous systemClinical trialsTau tanglesDirect cureSide effectsNervous systemCognitive defectsDiseaseMitochondrial dysfunctionReactive oxygen speciesGenetic mutationsAberrant signalingSpecific diseasesPsychological problemsCell deathPlaquesDisordersOxygen speciesA soy protein Lunasin can ameliorate amyloid-beta 42 mediated neurodegeneration in Drosophila eye
Sarkar A, Gogia N, Glenn N, Singh A, Jones G, Powers N, Srivastava A, Kango-Singh M, Singh A. A soy protein Lunasin can ameliorate amyloid-beta 42 mediated neurodegeneration in Drosophila eye. Scientific Reports 2018, 8: 13545. PMID: 30202077, PMCID: PMC6131139, DOI: 10.1038/s41598-018-31787-7.Peer-Reviewed Original ResearchConceptsRetinal neuronsNeuroprotective roleAlzheimer's diseaseHuman Aβ42Fatal progressive neurodegenerative disorderNovel neuroprotective roleProgressive neurodegenerative disorderAnti-cancer effectsPotential therapeutic agentJNK signalingAβ42 plaquesNeuronal deathNeuroprotective functionMortality rateTransgenic modelAxonal targetingNeurodegenerative disordersTherapeutic agentsCJun N-terminal kinaseNeurodegenerationOxidative stressAβ42NeuronsAbnormal signalingLunasin