An E3 ubiquitin ligase, cullin‐4 regulates retinal differentiation in Drosophila eye
Tare M, Chimata AV, Gogia N, Narwal S, Deshpande P, Singh A. An E3 ubiquitin ligase, cullin‐4 regulates retinal differentiation in Drosophila eye. Genesis 2020, 58: e23395. PMID: 32990387, PMCID: PMC9277906, DOI: 10.1002/dvg.23395.Peer-Reviewed Original ResearchConceptsCUL-4E3 ubiquitin ligaseEye developmentCullin 4Morphogenetic furrowRetinal differentiationUbiquitin ligaseCell deathForward genetic screenDrosophila eye modelEarly eye developmentSpecific cell typesGenetic screenDrosophila eyeGenomic stabilityEye phenotypeProcess of differentiationProtein degradationNegative regulatorGene expressionDevelopmental defectsFunction backgroundCell cycleMolecular mechanismsCell typesCharacterization of a morphogenetic furrow specific Gal4 driver in the developing Drosophila eye
Sarkar A, Gogia N, Farley K, Payton L, Singh A. Characterization of a morphogenetic furrow specific Gal4 driver in the developing Drosophila eye. PLOS ONE 2018, 13: e0196365. PMID: 29702674, PMCID: PMC5922546, DOI: 10.1371/journal.pone.0196365.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedBody PatterningCell DifferentiationDrosophila melanogasterDrosophila ProteinsGene Expression ProfilingGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsImmunohistochemistryIntracellular Signaling Peptides and ProteinsNuclear ProteinsPhenotypeProtein Serine-Threonine KinasesRetinaRetinal NeuronsTrans-ActivatorsTranscription FactorsTransforming Growth Factor betaWnt1 ProteinYAP-Signaling ProteinsConceptsMorphogenetic furrowPupal retinaGal4 driversGene expressionEye discEye developmentDrives expression