2024
Understanding how space travel affects the female reproductive system to the Moon and beyond
Mathyk B, Imudia A, Quaas A, Halicigil C, Karouia F, Avci P, Nelson N, Guzeloglu-Kayisli O, Denbo M, Sanders L, Scott R, Basar M, Guevara-Cerdán A, Strug M, Monseur B, Kayisli U, Szewczyk N, Mason C, Young S, Tasoglu S, Costes S, Beheshti A. Understanding how space travel affects the female reproductive system to the Moon and beyond. Npj Women's Health 2024, 2: 20. DOI: 10.1038/s44294-024-00009-z.Peer-Reviewed Original ResearchHypothalamic-pituitary-gonadalFemale reproductive systemEndometrial receptivityReproductive endocrinologyHealthy live birthPreimplantation embryo developmentHypothalamic-pituitary-gonadal (HPG) axisFemale reproductive healthReproductive systemOvarian folliculogenesisCircadian rhythm changesLive birthsEmbryo implantationFemale reproductive endocrinologyEffects of space travelPregnancySpace travelReproductive healthEmbryo developmentRhythm changesAdverse effectsEndocrinologySuccessful transitionEffects of spaceflightInterplanetary speciesEmbryology with precision: effective quality control in the in vitro fertilization laboratory
Basar M, Unsal E, Ergun Y. Embryology with precision: effective quality control in the in vitro fertilization laboratory. Current Opinion In Obstetrics & Gynecology 2024, 36: 200-207. PMID: 38572581, DOI: 10.1097/gco.0000000000000945.Peer-Reviewed Original ResearchConceptsPreimplantation genetic testingIn vitro fertilizationIntracytoplasmic sperm injectionProportion of mature oocytesIn vitro fertilization treatmentClinical pregnancy rateClinical practiceIn vitro fertilization laboratoryEmbryo development ratesImprove IVF outcomesSuccess rateImproving clinical outcomesField of reproductive medicineSperm injectionIVF outcomesClinical outcomesIVF treatmentDiagnostic accuracySuccess rate of IVF treatmentIVF proceduresPregnancy rateGenetic testingMature oocytesReproductive medicineGenetics laboratoriesMitochondrial Unfolded Protein Response Gene Clpp Is Required for Oocyte Function and Female Fertility
Ergun Y, Imamoglu A, Cozzolino M, Demirkiran C, Basar M, Garg A, Yildirim R, Seli E. Mitochondrial Unfolded Protein Response Gene Clpp Is Required for Oocyte Function and Female Fertility. International Journal Of Molecular Sciences 2024, 25: 1866. PMID: 38339144, PMCID: PMC10855406, DOI: 10.3390/ijms25031866.Peer-Reviewed Original ResearchConceptsCaseinolytic peptidase PMouse modelProtein homeostasisStress responseUnfolded protein stress responseProtein stress responseCumulus/granulosa cellsOocyte competenceOocyte functionGlobal deletionFunctional abnormalitiesGenes clpPMetabolic stress responseFemale subfertilityFemale infertilityOocyte-specificOocytesReproductive functionMtUPRMiceProtein degradationReproductive competenceFemale fertilityDeletionHomeostasisMitochondrial Unfolded Protein Response Gene Clpp Is Required for Oocyte Function and Female Fertility
PubmedPeer-Reviewed Original Research
2023
"The Role of Implantation Rate and Embryo Culture Conditions in IVF Success: An Opinion"
Basar M. "The Role of Implantation Rate and Embryo Culture Conditions in IVF Success: An Opinion". Biomedical Journal Of Scientific & Technical Research 2023, 53 DOI: 10.26717/bjstr.2023.53.008374.Peer-Reviewed Original ResearchHistorical Roadmap of Preimplantation Genetic Testing from Past to Present; What is Expected in the Future?
Basar M. Historical Roadmap of Preimplantation Genetic Testing from Past to Present; What is Expected in the Future? Reproductive Medicine Gynaecology & Obstetrics 2023, 8: 1-8. DOI: 10.24966/rmgo-2574/100129.Peer-Reviewed Original ResearchFlow Cytometry-Based Assay to Identify A Competent Embryo in FET Cycles
Akcay B, Meric N, Olcay I, Ergun Y, Boynukalin K, Arici A, Bahceci M, Basar M. Flow Cytometry-Based Assay to Identify A Competent Embryo in FET Cycles. Archives Of Clinical And Biomedical Research 2023, 07 DOI: 10.26502/acbr.50170357.Peer-Reviewed Original ResearchHistorical Roadmap of Preimplantation Genetic Testing from Past to Present; What is Expected in the Future?
@article{Basar_2023, doi = {10.24966/rmgo-2574/100129}, url = {https://doi.org/10.24966%2Frmgo-2574%2F100129}, year = 2023, month = {mar}, publisher = {Herald Scholarly Open Access}, volume = {8}, number = {1}, pages = {1--8}, author = {Murat Basar and}, title = {Historical Roadmap of Preimplantation Genetic Testing from Past to Present$\mathsemicolon$ What is Expected in the Future?}, journal = {Journal of Reproductive Medicine, Gynaecology {\&}amp$\mathsemicolon$ Obstetrics}}Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsThe Unseen Crisis: Embryologist Burnout and its Impact on IVF Success Rates
ISI IndexedCommentaries, Editorials and LettersThe Role of Implantation Rate and Embryo Culture Conditions in IVF Success: An Opinion
ISI IndexedPeer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2022
Mitochondrial Dysfunction, Mitophagy and Their Correlation with Perinatal Complications: Preeclampsia and Low Birth Weight
Yildirim R, Ergun Y, Basar M. Mitochondrial Dysfunction, Mitophagy and Their Correlation with Perinatal Complications: Preeclampsia and Low Birth Weight. Biomedicines 2022, 10: 2539. PMID: 36289801, PMCID: PMC9599185, DOI: 10.3390/biomedicines10102539.Peer-Reviewed Original ResearchLow birth weightBirth weightProgression of preeclampsiaFetal growthPerinatal complicationsFetal mortalityPlacental implantationPrenatal complicationsMitochondrial dysfunctionPreeclampsiaPathophysiologyReactive oxygen speciesReceptor-mediated mitophagyComplicationsMitochondrial quality control mechanismsAccumulation of damaged mitochondriaDysfunctionAccumulation of reactive oxygen speciesDouble-membrane vesiclesCellular survivalQuality control mechanismsAutophagy of mitochondriaPathologyOxygen speciesMitochondrial networkMITOCHONDRIAL STRESS RESPONSE GENE CLPP IS REQUIRED FOR OOCYTE FUNCTION AND FEMALE FERTILITY
Ergun Y, Imamoglu A, Cozzolino M, Demirkiran C, Basar M, Seli E. MITOCHONDRIAL STRESS RESPONSE GENE CLPP IS REQUIRED FOR OOCYTE FUNCTION AND FEMALE FERTILITY. Fertility And Sterility 2022, 118: e337. DOI: 10.1016/j.fertnstert.2022.09.126.Peer-Reviewed Original ResearchCHARACTERIZATION OF THE PROTEIN CONTENT OF PLATELET RICH PLASMA (PRP) AND A COMPARATIVE ANALYSIS OF DIFFERENCES AMONG TWO STRAINS OF MICE: IMPLICATIONS FOR REGENARATIVE STUDIES
Ergun Y, Demirkiran C, Yildirim R, Basar M, Seli E. CHARACTERIZATION OF THE PROTEIN CONTENT OF PLATELET RICH PLASMA (PRP) AND A COMPARATIVE ANALYSIS OF DIFFERENCES AMONG TWO STRAINS OF MICE: IMPLICATIONS FOR REGENARATIVE STUDIES. Fertility And Sterility 2022, 118: e337. DOI: 10.1016/j.fertnstert.2022.09.340.Peer-Reviewed Original ResearchICSI IS ASSOCIATED WITH LOWER BLASTULATION RATES COMPARED TO CONVENTIONAL IVF AMONG COUPLES WITH NON-MALE FACTOR INFERTILITY AND LOW OOCYTE YIELD
Beroukhim G, Seifer D, Chaplia O, Nichols-Burns S, Basar M, Halicigil C. ICSI IS ASSOCIATED WITH LOWER BLASTULATION RATES COMPARED TO CONVENTIONAL IVF AMONG COUPLES WITH NON-MALE FACTOR INFERTILITY AND LOW OOCYTE YIELD. Fertility And Sterility 2022, 118: e143. DOI: 10.1016/j.fertnstert.2022.08.419.Peer-Reviewed Original ResearchNoninvasive amino acid turnover predicts human embryo aneuploidy
Olcay IO, Akcay B, Bahceci M, Arici A, Boynukalin K, Yakicier C, Ozpinar A, Basar M. Noninvasive amino acid turnover predicts human embryo aneuploidy. Gynecological Endocrinology 2022, 38: 461-466. PMID: 35481385, DOI: 10.1080/09513590.2022.2068520.Peer-Reviewed Original ResearchConceptsEuploid groupAneuploid groupAmino acid turnoverAneuploid embryosHigher implantation rateAmino acid metabolism profilePotential diagnostic testPreimplantation genetic testingAcid turnoverBlank control groupEmbryo selection criteriaAssisted reproduction technologyMultiple pregnanciesImplantation ratePatient groupAmino acid concentrationsAneuploid blastocystsEmbryo aneuploidyControl groupDay 5IVF clinicsLow success rateGenetic testingCulture mediumTE biopsyThe Assessment of Purity Level of CO2 Used in Horizontal Incubators and The Effect of Additional In-Line Filters on Embryo Development/
DOI: 10.34297/AJBSR.2022.17.002323Peer-Reviewed Original ResearchMitochondrial Dysfunction, Mitophagy and Their Correlation with Perinatal Complications: Preeclampsia and Low Birth Weight
SCIPeer-Reviewed Original Research
2021
P–273 Effects of ovulation induction with GnRH Agonist (GnRHa) on oocyte and embryo quality at the mitochondrial level: A retrospective and experimental study
Basar M, Olcay O, Akcay B, Aydin S, Neslihan M, Findikli N. P–273 Effects of ovulation induction with GnRH Agonist (GnRHa) on oocyte and embryo quality at the mitochondrial level: A retrospective and experimental study. Human Reproduction 2021, 36: deab130.272. DOI: 10.1093/humrep/deab130.272.Peer-Reviewed Original ResearchGnRHa-treated groupsGnRHa triggerHCG groupGnRHa groupEmbryo qualityGnRH agonistHsp60 levelsGnRHa injectionFemale BALB/c miceOvarian hyperstimulation syndrome riskOld female BALB/c miceWestern blotBALB/c miceTotal gonadotropin doseOocyte maturationOvarian hyperstimulation protocolTRIAL REGISTRATION NUMBERMid-cycle surgeInduction of ovulationPARTICIPANTS/MATERIALSNumber of oocytesBetter embryo qualityFinal oocyte maturationROLE OF CHANCEOocyte nuclear maturation
2020
Efficacy of the GnRH Agonist Trigger in Oocyte and Embryo Quality Through Mitochondrial Unfolded Protein Response
Basar M. Efficacy of the GnRH Agonist Trigger in Oocyte and Embryo Quality Through Mitochondrial Unfolded Protein Response. Experimed 2020, 0: 0-0. DOI: 10.26650/experimed.1401479.Peer-Reviewed Original Research
2015
Progestins Upregulate FKBP51 Expression in Human Endometrial Stromal Cells to Induce Functional Progesterone and Glucocorticoid Withdrawal: Implications for Contraceptive- Associated Abnormal Uterine Bleeding
Kayisli O, Kayisli UA, Basar M, Semerci N, Schatz F, Lockwood CJ. Progestins Upregulate FKBP51 Expression in Human Endometrial Stromal Cells to Induce Functional Progesterone and Glucocorticoid Withdrawal: Implications for Contraceptive- Associated Abnormal Uterine Bleeding. PLOS ONE 2015, 10: e0137855. PMID: 26436918, PMCID: PMC4593551, DOI: 10.1371/journal.pone.0137855.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsAbnormal uterine bleedingEndometrial stromal cellsMedroxyprogesterone acetateGuinea pigsUterine bleedingCultured human endometrial stromal cellsStromal cellsGlandular cellsProgestin only contraceptivesEndometrial blood flowOvariectomized guinea pigsMajor side effectsEffective family planning methodsGlucocorticoid receptor activationGR transcriptional activityFragile blood vesselsFamily planning methodsIngenuity Pathway AnalysisFKBP51 expressionFunctional withdrawalMicroarray resultsOnly contraceptivesGlucocorticoid withdrawalEndometrial inflammation